NAMPT regulates PKM2 nuclear location through 14‐3‐3ζ: Conferring resistance to tamoxifen in breast cancer

FOXO1 functions in the regulation of nicotinamide phosphoribosyltransferase (Nampt) expression

(2019) Bora Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer

(2018) Bo-wen Liu et al.   ACTA PHARMACOLOGICA SINICA

Effect of pyruvate kinase M2-regulating aerobic glycolysis on chemotherapy resistance of estrogen receptor-positive breast cancer

(2018) Yuejun Qian et al.   ANTI-CANCER DRUGS

Down-regulation of NAMPT expression by mir-206 reduces cell survival of breast cancer cells

(2018) Zahra Hesari et al.   GENE

Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells

(2017) Mohammad Alaee et al.   Journal of Breast Cancer

Treatment for the endocrine resistant breast cancer: Current options and future perspectives

(2017) Chun-Yu Liu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

Extracellular NAMPT/Visfatin induces proliferation through ERK1/2 and AKT and inhibits apoptosis in breast cancer cells

(2017) Zafar Gholinejad et al.   PEPTIDES

Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway

(2017) Zhangxiao Peng et al.   Scientific Reports

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

(2017) Marina Riggio et al.   Scientific Reports

A novel orally bioavailable compound KPT-9274 inhibits PAK4 and blocks triple negative breast cancer tumor growth

(2017) Chetan Rane et al.   Scientific Reports

Descriptive epidemiology of breast cancer in China: incidence, mortality, survival and prevalence

(2016) Tong Li et al.   BREAST CANCER RESEARCH AND TREATMENT

Endocrine treatment in breast cancer: Cure, resistance and beyond

(2016) Konstantinos Tryfonidis et al.   CANCER TREATMENT REVIEWS

Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities

(2016) Hang Chen et al.   Expert Review of Anticancer Therapy

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

(2016) Abhishek Bhardwaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

(2016) Jiang Zhu et al.   Cell Death & Disease

Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance

(2016) Raie T. Bekele et al.   Scientific Reports

14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2

(2015) Jia Xu et al.   CANCER CELL

UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress

(2015) Daniel Gabriel Pons et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of 14-3-3 proteins in gynecological tumors

(2015) Xueqiong Zhu   Frontiers in Bioscience-Landmark

Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation

(2015) Gang Ma et al.   International Journal of Biological Sciences

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells

(2015) Bo Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

Clinical management of breast cancer heterogeneity

(2015) Dimitrios Zardavas et al.   Nature Reviews Clinical Oncology

NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer

(2015) S M Hong et al.   ONCOGENE

LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer

(2015) X Xue et al.   ONCOGENE

Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer

(2015) Qiong Li et al.   Scientific Reports

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

(2012) Barbara Chaneton et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance

(2011) A Bergamaschi et al.   ONCOGENE

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

14-3-3  Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival

(2009) C. L. Neal et al.   CANCER RESEARCH