AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Is There a Future for AKT Inhibitors in the Treatment of Cancer?

(2016) V. M. Jansen et al.   CLINICAL CANCER RESEARCH

Emerging therapeutics for targeting Akt in cancer

(2016) Alakananda Basu   Frontiers in Bioscience-Landmark

Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness

(2016) Aggeliki Tserga et al.   VIRCHOWS ARCHIV

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

Implications of Akt2/Twist crosstalk on breast cancer metastatic outcome

(2015) Lucília Pereira et al.   DRUG DISCOVERY TODAY

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

(2015) W.G. Jiang et al.   SEMINARS IN CANCER BIOLOGY

Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

(2015) María Laura Polo et al.   Oncotarget

Signalling specificity in the Akt pathway in breast cancer

(2014) Abbe R. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression

(2014) Helen C Plant et al.   BMC CANCER

PIK3CAMutations Are Associated With Lower Rates of Pathologic Complete Response to Anti–Human Epidermal Growth Factor Receptor 2 (HER2) Therapy in Primary HER2-Overexpressing Breast Cancer

(2014) Sibylle Loibl et al.   JOURNAL OF CLINICAL ONCOLOGY

Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis

(2013) Denise A. Yardley et al.   ADVANCES IN THERAPY

Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice

(2013) Katrina L Watson et al.   BMC CANCER

Akt2 expression is associated with good long-term prognosis in oestrogen receptor positive breast cancer

(2013) Helena Fohlin et al.   EUROPEAN JOURNAL OF CANCER

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110  Inhibitors in PIK3CA-Mutant Breast Cancer

(2013) M. Elkabets et al.   Science Translational Medicine

Proximity ligation assays for isoform-specific Akt activation in breast cancer identify activated Akt1 as a driver of progression

(2012) Melanie Spears et al.   JOURNAL OF PATHOLOGY

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

(2012) Reetta Virtakoivu et al.   MOLECULAR BIOLOGY OF THE CELL

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis

(2011) Shouye Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer

(2011) Marina Riggio et al.   CARCINOGENESIS

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

(2011) Nicole Grabinski et al.   CELLULAR SIGNALLING

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

(2011) B Weigelt et al.   ONCOGENE

Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers

(2010) Sunil Badve et al.   AMERICAN JOURNAL OF PATHOLOGY

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Akt2 regulates expression of the actin-bundling protein palladin

(2010) Y. Rebecca Chin et al.   FEBS LETTERS

Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

(2010) T. A. Yap et al.   MOLECULAR CANCER THERAPEUTICS

Responsiveness to PI3K and MEK Inhibitors in Breast Cancer. Use of a 3D Culture System to Study Pathways Related to Hormone Independence in Mice

(2010) Maria Laura Polo et al.   PLoS One

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

(2010) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

(2009) R. L. Dillon et al.   CANCER RESEARCH

Novel human breast cancer cell lines IBH-4, IBH-6, and IBH-7 growing in nude mice

(2009) Ariana Bruzzone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Akt/Protein Kinase B and Glycogen Synthase Kinase-3  Signaling Pathway Regulates Cell Migration through the NFAT1 Transcription Factor

(2009) M. Yoeli-Lerner et al.   MOLECULAR CANCER RESEARCH

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

(2008) Y. Rebecca Chin et al.   CELLULAR SIGNALLING