Article
Neurosciences
Chen Shen, Cong Chen, Tong Wang, Tong-Yao Gao, Min Zeng, Yun-Bi Lu, Wei-Ping Zhang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in the salvaging synthesis pathway of nicotinamide adenine dinucleotide (NAD). Depletion of NAMPT can lead to cognitive deficiency in hippocampus neurons and increase the risk of neurodegeneration due to mitochondrial dysfunction.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wenjing Xu, Yuelin Chao, Minglu Liang, Kai Huang, Cheng Wang
Summary: The study reveals the important role of CTRP13 in preventing AAA formation, showing its ability to reduce the incidence and severity of AAA, as well as decrease vascular inflammation and SMC apoptosis.
Article
Oncology
Loai Saleh Albinsaad, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn, Sae Byul Lee
Summary: This study aimed to investigate the relationship between p53 expression and the outcomes of neoadjuvant chemotherapy in HR-positive, HER2-negative breast cancer patients. The results showed that high expression of p53 was strongly associated with decreased overall survival and breast cancer-specific survival.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Maximilian Clausing, Doreen William, Matthias Preussler, Julia Biedermann, Konrad Gruetzmann, Susan Richter, Frank Buchholz, Achim Temme, Evelin Schroeck, Barbara Klink
Summary: The IDH1(R132H) mutation in glioma leads to the production of the oncometabolite 2-HG and changes in cellular redox balance. The study reveals that targeting the NAD(+) synthesis pathway is a promising therapeutic strategy in IDH mutant gliomas, but the available NAMPT inhibitors are not suitable for this purpose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Cuiyan Zhou, Weihai Ying
Summary: This study found that oxidative stress can lead to a decrease in Nampt level, which plays important roles in NAD(+) synthesis and cell survival. The findings suggest that Nampt plays crucial roles in maintaining NAD(+) levels and cell survival under both basal and oxidative stress conditions.
Article
Biochemistry & Molecular Biology
Shahin Alizadeh-Fanalou, Saman Hosseinkhani, Ali Nazarizadeh, Samira Ezzati-Mobaser, Zahra Hesari, Parisa Aziminezhadan, Zohreh Abdolvahabi, Meysam Abolmaali, Masoumeh Tavakoli-Yaraki, Mitra Nourbakhsh
Summary: Targeting the NAMPT-mediated NAD salvage pathway by miR-613 is a novel approach for managing breast cancer, which is worth further investigation.
DNA AND CELL BIOLOGY
(2021)
Article
Oncology
Yongxian Zhuang, Allison B. B. Haugrud, Meg A. A. Schaefer, Shanta M. M. Messerli, W. Keith Miskimins
Summary: Depletion of cellular NAD+ is a critical factor in the sensitivity of cancer cells to the cytotoxic effects of metformin. NAMPT plays a key role in maintaining sufficient levels of NAD+, and cancer cells that express elevated levels of NAMPT are resistant to metformin's killing effect.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Alanna B. Chan, Gian Carlo G. Parico, Jennifer L. Fribourgh, Lara H. Ibrahim, Michael J. Bollong, Carrie L. Partch, Katja A. Lamia
Summary: Disruption of circadian rhythms can increase the risk of various cancers. Mutations in the CRY2 gene found in human cancers have been shown to accelerate cell growth in mouse fibroblasts expressing high levels of c-MYC. These mutations also have divergent effects on circadian rhythms and interaction with SCFFBXL3.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Melika Ameli Mojarad, Mandana Ameli Mojarad, Alireza Pourmahdian
Summary: The study demonstrated that miR-26b can suppress the growth of breast cancer cells by downregulating NAMPT expression, NAD concentration, and cell viability, suggesting that miR-26b could be a promising target for breast cancer treatment.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Melika Ameli Mojarad, Mandana Ameli Mojarad, Alireza Pourmahdian
Summary: This study highlights the significant tumor suppressor role of miR-26b in breast cancer, inhibiting cell growth and survival by targeting NAMPT and NAD levels. This makes miR-26b a promising target for breast cancer treatment.
DNA AND CELL BIOLOGY
(2022)
Review
Cell Biology
Md Ataur Rahman, Moon Nyeo Park, Md Hasanur Rahman, Md Mamunur Rashid, Rokibul Islam, Md Jamal Uddin, Md Abdul Hannan, Bonglee Kim
Summary: p53, the key tumor suppressor protein, plays a significant role in regulating various biological processes, including energy metabolism, cell cycle, apoptosis, and more. Autophagy, a crucial cellular process, is involved in maintaining cellular homeostasis. The relationship between p53 and autophagy is complex and not completely understood, as p53 can both inhibit and activate autophagy depending on its cellular localization and mode of action. Understanding the interaction between p53 and autophagy is important for cancer treatment and management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
F. Ayala de la Pena, B. Ortiz-Munoz, T. Quintanar-Verduguez, J. D. Santotoribio, S. de la Cruz, J. Trape-Pujol, E. Galve-Calvo, J. M. Auge-Fradera, J. Garcia-Gomez, A. Gonzalez-Hernandez
Summary: This article summarizes the use and interpretation of circulating tumor markers in breast cancer, focusing on their relationship with molecular subtypes and prognostic value. It also proposes a series of recommendations to improve the clinical utility of TMs.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Fang Tian, Jie Zhao, Qing-Fang Shi, Deng-Cai Zhang, Yue-Yuan Wang, Jian-Ping Sun, Yan Wang, Si-Ang Yang, Chong Zhang
Summary: The study explored the association between immunohistochemical markers and phyllodes tumor and found that CD10 expression was independently associated with PT and has the potential to be used as a differentiation marker.
Article
Oncology
Frederic A. Vallejo, Anthony Sanchez, Branko Cuglievan, Winston M. Walters, Guillermo De Angulo, Steven Vanni, Regina M. Graham
Summary: NAMPT has been identified as a potential therapeutic target for high-risk neuroblastoma. Inhibition of NAMPT leads to decreased ATP levels, induced apoptosis, reduced stem cell self-renewal, and blocked tumor growth.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Taylor P. Berke, Simon H. Slight, Salman M. Hyder
Summary: The tumor suppressor protein p53 plays a crucial role in preventing cancer. Mutations in the p53 gene are associated with various cancers. Reactivating mutant p53 protein and controlling the progression of triple-negative breast cancer (TNBC) through the use of non-toxic natural compounds is recommended.
ONCOTARGETS AND THERAPY
(2022)
Article
Oncology
Zahra Fakhroueian, Sadegh Rajabi, Niloufar Salehi, Mostafa Rezaei Tavirani, Shokoofe Noori, Mitra Nourbakhsh
Summary: The effects of three synthesized ZnO nanofluids on breast cancer stem-like cells were evaluated in this study. The results showed that ZnO nanofluids could decrease the expression of stemness markers, induce apoptosis, and suppress JAK/STAT activity. ZnO-148 exhibited the most effective activity.
Article
Integrative & Complementary Medicine
Zahra Malekpour-Dehkordi, Mitra Nourbakhsh, Minoo Shahidi, Nazanin Sarraf, Roya Sharifi
Summary: This study found that silymarin can reduce lipogenesis and decrease ER stress, showing potential efficacy in the treatment of non-alcoholic fatty liver disease.
JOURNAL OF HERBAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sahar Yarahmadi, Navid Farahmandian, Reza Fadaei, Mehdi Koushki, Elham Bahreini, Saeed Karima, Sepideh Barzin Tond, Azadeh Rezaei, Mitra Nourbakhsh, Soudabeh Fallah
Summary: The study investigated the effects of resveratrol, atorvastatin, and their combination on gene expression in the cholesterol metabolic pathway in fatty liver. The results showed that resveratrol and atorvastatin reduced fat accumulation in the liver and improved blood lipid profiles compared to the control group. The combination therapy had significant effects on the expression of genes related to cholesterol metabolism and miR33.
DNA AND CELL BIOLOGY
(2023)
Article
Cell Biology
Mitra Nourbakhsh, Shokoofe Noori, Zahra Aminzade, Maryam Bayanati, Mehrdad Alemi, Afshin Zarghi
Summary: This study investigated the effects of a novel chalcone derivative MPP in combination with curcumin on the inflammatory pathways in breast and ovarian cancer cells. The results showed that MPP inhibited NF-κB activity, reduced the expression of inflammatory genes, and decreased the levels of proinflammatory cytokines and nitric oxide. These effects were enhanced when MPP was combined with curcumin.
MEDIATORS OF INFLAMMATION
(2023)
Article
Endocrinology & Metabolism
N. Heydari, R. Sharifi, M. Nourbakhsh, P. Golpour
Summary: This study aimed to investigate the expression of lncRNAs TUG1, MALAT1, and MEG3 in patients with type 2 diabetes and their association with biochemical and ER stress parameters. The results showed that the expression of TUG1, MEG3, ATF4, and CHOP genes was significantly increased in patients with diabetes. The expression levels of TUG1 and MEG3 were positively correlated with glycemic control indices and markers of ER stress, suggesting their potential as markers for identifying ER stress in hyperglycemia.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cell Biology
Reza Ataei Kachouei, Alireza Doagoo, Maral Jalilzadeh, Seyyed Hossein Khatami, Shima Rajaei, Ali Jahanbazi Jahan-Abad, Farzaneh Salmani, Roya Pakrad, Somayeh Mahmoodi Baram, Mitra Nourbakhsh, Mohammad-Amin Abdollahifar, Hojjat Allah Abbaszadeh, Shokoofeh Noori, Mitra Rezaei, Meisam Mahdavi, Mohammad Reza Shahmohammadi, Saeed Karima
Summary: This study investigates the potential of Acetyl-11-keto-beta-boswellic acid (AKBA), an anti-inflammatory compound from Boswellia species, in preventing and treating non-alcoholic fatty liver disease (NAFLD). The results demonstrate that AKBA improves NAFLD-related serum parameters and inflammatory markers, preserves lipid metabolism, improves hepatic steatosis, and suppresses liver inflammation, thus preventing the progression of NAFLD.
Article
Biochemistry & Molecular Biology
Zeinab Babaei, Mojtaba Panjehpour, Seyedeh Sara Ghorbanhosseini, Hadi Parsian, Mahsa Khademi, Mahmoud Aghaei
Summary: This study demonstrated the signaling pathways of VEGFR3 in ovarian cancer cells through upregulated expression of miR-1236. Inhibition of VEGFR3 using miR-1236 reduced cell proliferation, migration, and invasion ability, and increased apoptosis rate in SKOV3 and OVCAR3 cells. Additionally, VEGFR3 stimulation increased ERK1/2 and AKT phosphorylation, while VEGFR3 suppression resulted in decreased phosphorylation of ERK1/2 and AKT. These findings suggest that the miR-1236/VEGFR3 axis regulates ovarian cancer cell proliferation by modulating ERK1/2 and AKT signaling, providing a potential therapeutic strategy against ovarian cancer.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Medical Laboratory Technology
Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani
Summary: This study investigated the associations of two newly discovered adipokines, Metrnl and asprosin, with obesity in children and adolescents. The results showed that Metrnl levels were lower in obese children, while asprosin levels were higher. These adipokines were correlated with obesity-related parameters such as BMI and insulin levels. Therefore, Metrnl and asprosin are potential therapeutic targets for obesity and its associated metabolic imbalances.
LABORATORY MEDICINE
(2023)
Article
Neurosciences
Niloufar Salehi, Mitra Nourbakhsh, Shokoofe Noori, Hossein Rezaeizadeh, Afshin Zarghi
Summary: This study investigates the ameliorating effect of Tehranolide (TEH) and Artemisinin (ART) on experimental autoimmune encephalomyelitis (EAE), a commonly used animal model for multiple sclerosis (MS). Both TEH and ART significantly alleviate EAE signs, with TEH showing greater potency. By modulating the expression of genes related to inflammation and myelination, TEH has the potential to be evaluated as an intervention for MS management.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Havva Afshari, Shokoofe Noori, Mitra Nourbakhsh, Azam Daraei, Mahsa Azami Movahed, Afshin Zarghi
Summary: This study aimed to synthesize a novel imidazo[1,2-a]pyridine derivative (MIA) and evaluate its anti-inflammatory activity and effects on NF-κB and STAT3 pathways in MDA-MB-231 and SKOV3 cell lines. The results showed that MIA exerted its anti-inflammatory activity by suppressing NF-κB and STAT3 signaling pathways, and curcumin enhanced all the anti-inflammatory effects of MIA.
Article
Integrative & Complementary Medicine
Alemeh Taheri, Samira Ezzati Mobaser, Pegah Golpour, Mona Nourbakhsh, Masoumeh Tavakoli-Yaraki, Sahar Yarahmadi, Mitra Nourbakhsh
Summary: In this study, the anti-fibrotic effects of hesperetin were investigated by targeting ECM components and matrix metalloproteinase enzymes. The results showed that hesperetin significantly reduced the production of markers of adipose tissue fibrosis and may be considered a potential compound for the treatment of obesity-associated fibrosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Genetics & Heredity
Mohammad Borji, Nikta Dadkhah Nikroo, Zeynab Yousefi, Mona Nourbakhsh, Zohreh Abdolvahabi, Mitra Nourbakhsh, Bagher Larijani, Maryam Razzaghy-Azar
Summary: The gene expression of CHREBP is elevated in individuals with obesity and metabolic syndrome, and it is associated with various metabolic and liver-related parameters.
Meeting Abstract
Endocrinology & Metabolism
Mitra Nourbakhsh, Mona Nourbakhsh, Pegah Golpour, Hosein Momeni, Maryam Razzaghy Azar
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Mona Nourbakhsh, Nastaran Ramezani, Mitra Nourbakhsh, Maryam Razzaghy Azar
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Integrative & Complementary Medicine
Shokoofe Noori, Mitra Nourbakhsh, Hossein Imani, Niloofar Deravi, Niloufar Salehi, Zohreh Abdolvahabi
Summary: This study investigated the potential of using a combination of naringenin and CPT to modulate the immune response and inhibit tumor growth. The results showed promising effects of this combination in regulating immune response and inhibiting tumor growth, possibly through the JAK2/STAT3 signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)