AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain

Structural Insights into the Altering Function of CRMP2 by Phosphorylation

(2018) Takuya Sumi et al.   CELL STRUCTURE AND FUNCTION

Mapping protein interactions of sodium channel Na V 1.7 using epitope‐tagged gene‐targeted mice

(2018) Alexandros H Kanellopoulos et al.   EMBO JOURNAL

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

(2018) Yiyan Zheng et al.   Nature Communications

BK Potassium Channels Suppress Cavα2δ Subunit Function to Reduce Inflammatory and Neuropathic Pain

(2018) Fang-Xiong Zhang et al.   Cell Reports

Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia

(2018) Tomoya Terashima et al.   Molecular Therapy-Nucleic Acids

Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain

(2017) Temugin Berta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno-associated virus delivery in adult rats

(2017) Hongfei Xiang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Primary sensory neuron-specific interference of TRPV1 signaling by adeno-associated virus-encoded TRPV1 peptide aptamer attenuates neuropathic pain

(2017) Hongfei Xiang et al.   Molecular Pain

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration

(2017) JanC Koch et al.   Neural Regeneration Research

Ca V 2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons

(2017) Zuying Chai et al.   NEURON

Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors

(2017) Aubin Moutal et al.   PAIN

Efficacy of a Targeted Drug Delivery on-Demand Bolus Option for Chronic Pain

(2017) Robert B. Bolash et al.   Pain Practice

Bilirubin augments Ca2+ load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels

(2017) Min Liang et al.   Scientific Reports

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit

(2017) Ivan Kadurin et al.   Scientific Reports

Peripheral nerve injury induces loss of nociceptive neuron-specific Gαi-interacting protein in neuropathic pain rat

(2016) Zhen Liu et al.   Molecular Pain

The Dorsal Root Ganglion in the Pathogenesis of Chronic Neuropathic Pain

(2016) Daipayan Guha et al.   NEUROSURGERY

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential

(2016) Jennifer Y. Xie et al.   PAIN

CaMKII Controls Whether Touch Is Painful

(2015) H. Yu et al.   JOURNAL OF NEUROSCIENCE

The Upregulation of α2δ-1 Subunit Modulates Activity-Dependent Ca2+Signals in Sensory Neurons

(2015) Marianna D'Arco et al.   JOURNAL OF NEUROSCIENCE

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

(2015) Gerald W. Zamponi   NATURE REVIEWS DRUG DISCOVERY

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

(2015) Liberty François-Moutal et al.   PAIN

Successful Management of Corneal Neuropathic Pain with Intrathecal Targeted Drug Delivery

(2015) Salim M. Hayek et al.   PAIN MEDICINE

Relieving Pain in America

(2014) Victor J. Dzau et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Collapsin Response Mediator Protein 2 (CRMP2) Interacts withN-Methyl-d-aspartate (NMDA) Receptor and Na+/Ca2+Exchanger and Regulates Their Functional Activity

(2014) Tatiana Brustovetsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

CRMP2

(2014) Jacque P.K. Ip et al.   NEUROSCIENTIST

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary  2 -1 subunits

(2014) J. S. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury

(2014) Sarah M. Wilson et al.   Frontiers in Cellular Neuroscience

CDK5, CRMP2 and NR2B in spinal dorsal horn and dorsal root ganglion have different role in pain signaling between neuropathic pain model and inflammatory pain model

(2013) Y. Kamiya et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion

(2013) G Fischer et al.   GENE THERAPY

CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking

(2013) Erik T. Dustrude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats

(2013) Hongwei Yu et al.   PLoS One

Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain

(2012) S Vink et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disruption of NMDAR–CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

(2012) Joel M. Brittain et al.   Channels

Relieving Pain in America

(2012) John D. Loeser   CLINICAL JOURNAL OF PAIN

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2

(2012) Joel M. Brittain et al.   FEBS LETTERS

Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide

(2012) Weina Ju et al.   JOURNAL OF NEUROCHEMISTRY

CRMP-2 Peptide Mediated Decrease of High and Low Voltage-Activated Calcium Channels, Attenuation of Nociceptor Excitability, and Anti-Nociception in a Model of AIDS Therapy-Induced Painful Peripheral Neuropathy

(2012) Andrew D Piekarz et al.   Molecular Pain

α2δ expression sets presynaptic calcium channel abundance and release probability

(2012) Michael B. Hoppa et al.   NATURE

A peptide uncoupling CRMP-2 from the presynaptic Ca2+ channel complex demonstrates efficacy in animal models of migraine and AIDS therapy-induced neuropathy

(2012) Matthew Ripsch et al.   Translational Neuroscience

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel–CRMP-2 signaling complex

(2011) Sarah M. Wilson et al.   Channels

Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development

(2011) Terry Pexton et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Direct injection into the dorsal root ganglion: Technical, behavioral, and histological observations

(2011) Gregory Fischer et al.   JOURNAL OF NEUROSCIENCE METHODS

Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+channel peptides

(2011) Giovanna Bucci et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lentiviral Gene Transfer into the Dorsal Root Ganglion of Adult Rats

(2011) gwei Yu et al.   Molecular Pain

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of pain

(2010) Sriram Tyagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Calcium channel functions in pain processing

(2010) John Park et al.   Channels

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons

(2010) Shao-Gang Lu et al.   PAIN

Labat Lecture: The Primary Sensory Neuron

(2010) Quinn H. Hogan   REGIONAL ANESTHESIA AND PAIN MEDICINE

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

An Atypical Role for Collapsin Response Mediator Protein 2 (CRMP-2) in Neurotransmitter Release via Interaction with Presynaptic Voltage-gated Calcium Channels

(2009) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

(2009) X. X. Chi et al.   JOURNAL OF CELL SCIENCE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Learned Avoidance From Noxious Mechanical Simulation But Not Threshold Semmes Weinstein Filament Stimulation After Nerve Injury in Rats

(2009) Hsiang-En Wu et al.   JOURNAL OF PAIN

Targeting voltage-gated calcium channels for neuropathic pain management

(2009) Danielle Perret et al.   Neurotherapeutics

Peptides Targeting Voltage-Gated Calcium Channels

(2008) Raymond Norton et al.   CURRENT PHARMACEUTICAL DESIGN