Calcium channel functions in pain processing

Recent Updates of N-Type Calcium Channel Blockers with Therapeutic Potential for Neuropathic Pain and Stroke

(2012) Takashi Yamamoto et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminalsin vivo: Figure 1

(2010) Claudia S. Bauer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interference between two modulators of N-type (CaV2.2) calcium channel gating demonstrates that ω-conotoxin GVIA disrupts open state gating

(2010) Viktor Yarotskyy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Acute modulation of calcium currents and synaptic transmission by gabapentinoids

(2010) Osvaldo D. Uchitel et al.   Channels

Regulation of calcium channels by RGK proteins

(2010) Robyn Flynn et al.   Channels

Knockdown of L Calcium Channel Subtypes: Differential Effects in Neuropathic Pain

(2010) P. Fossat et al.   JOURNAL OF NEUROSCIENCE

Cav3.2 T-Type Ca2+ Channel-Dependent Activation of ERK in Paraventricular Thalamus Modulates Acid-Induced Chronic Muscle Pain

(2010) W.-K. Chen et al.   JOURNAL OF NEUROSCIENCE

Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker

(2010) C. Abbadie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes

(2010) Dustin Anderson et al.   NATURE NEUROSCIENCE

Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing

(2010) Arturo Andrade et al.   NATURE NEUROSCIENCE

Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC

(2010) Daejong Jeon et al.   NATURE NEUROSCIENCE

Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

(2010) Tomoko Takahashi et al.   PAIN

The Roles of T-Type Calcium Channel in the Development of Neuropathic Pain following Chronic Compression of Rat Dorsal Root Ganglia

(2010) Xian-Jie Wen et al.   PHARMACOLOGY

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Calcium channel diversity: multiple roles of calcium channel subunits

(2009) Annette C Dolphin   CURRENT OPINION IN NEUROBIOLOGY

Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice

(2009) J. R. Latham et al.   DIABETES

The voltage-gated calcium-channel β subunit: more than just an accessory

(2009) Yamuna Karunasekara et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Heterodimerization of ORL1 and Opioid Receptors and Its Consequences for N-type Calcium Channel Regulation

(2009) Rhian M. Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Enhanced Pre-Synaptic Glutamate Release in Deep-Dorsal Horn Contributes to Calcium Channel Alpha-2-Delta-1 Protein-Mediated Spinal Sensitization and Behavioral Hypersensitivity

(2009) David Nguyen et al.   Molecular Pain

G Protein-Mediated Inhibition of Cav3.2 T-Type Channels Revisited

(2009) E. Perez-Reyes   MOLECULAR PHARMACOLOGY

Presynaptic CaV2 calcium channel traffic requires CALF-1 and the α2δ subunit UNC-36

(2009) Yasunori Saheki et al.   NATURE NEUROSCIENCE

Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya

(2009) N. Fukumoto et al.   NEUROSCIENCE

Targeting voltage-gated calcium channels for neuropathic pain management

(2009) Danielle Perret et al.   Neurotherapeutics

In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

(2009) Richard B. Messinger et al.   PAIN

Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Cav3.2 T-type calcium channels

(2009) Yumi Maeda et al.   PAIN

Mechanisms of analgesia by gabapentin and pregabalin – Calcium channel α2-δ [Cavα2-δ] ligands

(2009) Charles P. Taylor   PAIN

Regulation of T-type calcium channels: Signalling pathways and functional implications

(2008) Sylvaine Huc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Differential expression of L- and N-type voltage-sensitive calcium channels in the spinal cord of morphine+nimodipine treated rats

(2008) Dilip Verma et al.   BRAIN RESEARCH

Novel Splice Variants of Rat CaV2.1 That Lack Much of the Synaptic Protein Interaction Site Are Expressed in Neuroendocrine Cells

(2008) W. R. A. Kosala J. S. Rajapaksha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cav1 L-type Ca2+channel signaling complexes in neurons

(2008) Irina Calin-Jageman et al.   JOURNAL OF NEUROCHEMISTRY

Upregulation of the T-Type Calcium Current in Small Rat Sensory Neurons After Chronic Constrictive Injury of the Sciatic Nerve

(2008) Miljen M. Jagodic et al.   JOURNAL OF NEUROPHYSIOLOGY

ω-Conotoxin GVIA Alters Gating Charge Movement of N-Type (CaV2.2) Calcium Channels

(2008) Viktor Yarotskyy et al.   JOURNAL OF NEUROPHYSIOLOGY

Role of Spinal Cav2.2 and Cav2.1 Ion Channels in Bladder Nociception

(2008) Xin Su et al.   JOURNAL OF UROLOGY

Alternative Splicing of the Ca2+ Channel  4 Subunit Confers Specificity for Gabapentin Inhibition of Cav2.1 Trafficking

(2008) P. M. Mich et al.   MOLECULAR PHARMACOLOGY

Calcium Channel Regulation and Presynaptic Plasticity

(2008) William A. Catterall et al.   NEURON

Pharmacological disruption of calcium channel trafficking by the  2  ligand gabapentin

(2008) J. Hendrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of neuronal T-type calcium channels

(2008) Mircea C. Iftinca et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channel

(2007) Victoria L. Haller et al.   EUROPEAN JOURNAL OF PHARMACOLOGY