CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking

SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons

(2013) Weina Ju et al.   Channels

Identification of the Benzyloxyphenyl Pharmacophore: A Structural Unit That Promotes Sodium Channel Slow Inactivation

(2012) Amber M. King et al.   ACS Chemical Neuroscience

Drug Binding Assays do not Reveal Specific Binding of Lacosamide to Collapsin Response Mediator Protein 2 (CRMP-2)

(2012) Christian Wolff et al.   CNS Neuroscience & Therapeutics

Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segment

(2012) Helene Vacher et al.   EPILEPSIA

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2

(2012) Joel M. Brittain et al.   FEBS LETTERS

Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+Channel Peptides

(2012) Sarah M. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Dorsal root ganglia isolated from Nf1+/− mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels

(2012) K.E. Hodgdon et al.   NEUROSCIENCE

Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization

(2012) S.M. Wilson et al.   NEUROSCIENCE

Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-Gated Sodium Channels and in the Treatment of Neuropathic Pain

(2011) Yuying Wang et al.   ACS Chemical Neuroscience

Neuroprotection against Traumatic Brain Injury by a Peptide Derived from the Collapsin Response Mediator Protein 2 (CRMP2)

(2011) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons

(2011) Leigh D. Plant et al.   JOURNAL OF GENERAL PHYSIOLOGY

Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7

(2011) Mark Estación et al.   Molecular Pain

Inhibition of Nav 4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide

(2011) J. W. Theile et al.   MOLECULAR PHARMACOLOGY

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis

(2011) F. A. Konopacki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

(2011) A. Morinaka et al.   Science Signaling

Development and Characterization of Novel Derivatives of the Antiepileptic Drug Lacosamide That Exhibit Far Greater Enhancement in Slow Inactivation of Voltage-Gated Sodium Channels

(2010) Yuying Wang et al.   ACS Chemical Neuroscience

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Targets and consequences of protein SUMOylation in neurons

(2010) Kevin A. Wilkinson et al.   BRAIN RESEARCH REVIEWS

Sodium channel SCN1A and epilepsy: Mutations and mechanisms

(2010) Andrew Escayg et al.   EPILEPSIA

In SilicoDocking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation

(2010) Yuying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage-gated sodium channel organization in neurons: Protein interactions and trafficking pathways

(2010) Christophe Leterrier et al.   NEUROSCIENCE LETTERS

Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group

(2010) Ki Duk Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity

(2010) Jacqueline C. Merrill et al.   PLoS One

One SUMO is sufficient to silence the dimeric potassium channel K2P1

(2010) L. D. Plant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin polymerization modifies cardiac sodium channel expression and gating

(2009) Simona Casini et al.   CARDIOVASCULAR RESEARCH

Protein–protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression

(2009) Dongmin Shao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An Atypical Role for Collapsin Response Mediator Protein 2 (CRMP-2) in Neurotransmitter Release via Interaction with Presynaptic Voltage-gated Calcium Channels

(2009) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

(2009) X. X. Chi et al.   JOURNAL OF CELL SCIENCE

Sensory neuron voltage-gated sodium channels as analgesic drug targets

(2008) Aliakmal Momin et al.   CURRENT OPINION IN NEUROBIOLOGY

Small Ubiquitin-related Modifier (SUMO) Binding Determines Substrate Recognition and Paralog-selective SUMO Modification

(2008) Jianmei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Analysis of SUMO-1 modification of neuronal proteins containing consensus SUMOylation motifs

(2008) Kevin A. Wilkinson et al.   NEUROSCIENCE LETTERS