Article
Behavioral Sciences
Olga Rodriguez-Borillo, Lorena Rosello-Jimenez, Julian Guarque-Chabrera, Maria Palau-Batet, Isis Gil-Miravet, Raul Pastor, Marta Miquel, Laura Font
Summary: After cocaine exposure, increased cFos activity was observed in the granular cell layer at the top of the posterior vermis (lobules VIII and IX) in mice, and this activity was positively correlated with cFos expression in the medial prefrontal cortex. These findings suggest that certain regions of the cerebellum may be involved in the regulation of cocaine-conditioned behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Yang Chen, Libo Zhang, Zengbo Ding, Xianwen Wu, Guibin Wang, Jie Shi
Summary: 3-MMC, a synthetic cathinone, has addictive potential and affects anxiety-like behavior. The study revealed that 3-MMC can induce rewarding effect and exhibit anxiolytic-like effect, but long-term exposure increased anxiety-like behavior. Brain mapping showed increased c-Fos expression in anterior cingulate cortex, nucleus accumbens, and ventral tegmental area. Additionally, 3-MMC inhibited inhibitory synaptic transmission in nucleus accumbens.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Changqiong Xu, Ran Li, Jie Wu
Summary: YHZTP can attenuate the expression of ethanol-induced CPP in mice, while a combination of l-THP and IMP exerts a synergistic effect on reducing ethanol-induced CPP. Possible pharmacological mechanisms include inhibition of inflammatory factors expression and regulation of neurotransmitter receptor levels.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Psychology, Biological
Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-ih, Ekkasit Kumarnsit
Summary: This study aimed to investigate the neural adaptive mechanisms associated with the formation of morphine conditioned place preference. The findings suggested that NAc LFP signaling and neural connectivities between the NAc and HC may play a role in morphine CPP.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Meng-Jing Zhao, Mi-Ya Wang, Le Ma, Khalil Ali Ahmad, Yong-Xiang Wang
Summary: The study showed that BAA attenuated morphine-induced withdrawal symptoms, CPP expression, and locomotor sensitization by stimulating microglial dynorphin A expression in the brain. This suggests that BAA may be a potential candidate for treating opioids-induced physical dependence and addiction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenbin Jia, Ichiro Kawahata, An Cheng, Takuya Sasaki, Toshikuni Sasaoka, Kohji Fukunaga
Summary: We confirmed that the FABP3 inhibitor, MF1, successfully reduces nicotine-induced conditioned place preference in mice. MF1 treatment decreased CPP scores in a dose-dependent manner by inhibiting the activation of CaMKII and ERK in the nucleus accumbens and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Marco Rafael Guimaraes, Sandra Isabel Anjo, Ana Margarida Cunha, Madalena Esteves, Nuno Sousa, Armando Almeida, Bruno Manadas, Hugo Leite-Almeida
Summary: The study found that a small subset of rats with peripheral neuropathy showed high thresholds to mechanical allodynia and exhibited higher hedonic behavior. Proteomic analysis revealed differences in protein expression related to the proteasome pathway between animals with low and high thresholds, suggesting an overactivation of the accumbal proteasome pathway in animals manifesting pain and depressive-like behaviors after a neuropathic injury.
Article
Neurosciences
Jakkrit Nukitram, Ekkasit Kumarnsit, Dania Cheaha
Summary: This study examined the effects of cannabidiol to tetrahydrocannabinol ratio on the conditioned place preference of methamphetamine in mice and found that cannabidiol reversed the preference behavior possibly through modulation of neural signaling in specific brain areas.
BRAIN RESEARCH BULLETIN
(2023)
Article
Behavioral Sciences
Skyler M. Sklenarik, Christopher N. Burrows, Robert S. Astur
Summary: This study examines the establishment of conditioned place preference (CPP) using virtual alcohol cues and finds that participants with alcohol use spend significantly more time in the conditioned room compared to participants without alcohol use during the test session. However, participants with alcohol use do not subjectively report a preference for the conditioned room.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
L. Rocco, A. Pisera-Fuster, M. P. Faillace, R. Bernabeu
Summary: This study used a modified conditioned place preference paradigm to assess zebrafish's preference for nicotine and its association with environmental cues. The results showed that zebrafish's seeking behavior was closely related to the shades of compartment colors, and they spent more time in the environment associated with nicotine.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Zahra Ebrahimi, Nazanin Kahvandi, Elahe Shahriari, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Maryam Sharifi, Abdolrahman Sarihi
Summary: Nucleus accumbens (NAc) neurons play a critical role in reward circuitry, and new evidence suggests that mGlu4 receptors in NAc are involved in the regulation of morphine-induced conditioned place preference (CPP) through glutamate-mediated transmission.
BRAIN RESEARCH BULLETIN
(2023)
Article
Behavioral Sciences
Nazanin Kahvandi, Zahra Ebrahimi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Marzieh Naderishahab, Abdolrahman Sarihi
Summary: The study found that administration of the mGlu8 receptor agonist S-3,4-DCPG in the NAc dose-dependently reduced the acquisition phase of morphine-induced CPP, but had no effect on the expression phase.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Clinical Neurology
Luisa Alessandra Atehortua Martinez, Emmanuel Curis, Nawel Mekdad, Claire Larrieu, Cindie Courtin, Laurent Jourdren, Corinne Blugeon, Jean-Louis Laplanche, Bruno Megarbane, Cynthia Marie-Claire, Nadia Benturquia
Summary: The study investigated the variability in the expression of the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm and identified differentially expressed genes in the nucleus accumbens (NAc) between rats that did or did not express cocaine-induced place preference. The findings provide insights into the mechanisms underlying interindividual variability in response to cocaine's rewarding effects, with immediate early genes showing differential expression in CPPE rats.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Summary: This study investigates the influence of chronic short sleep on opioid reward using a mouse model. The results show that recovery sleep after chronic sleep disruption lessens voluntary opioid intake, but does not affect conditioned reward associated with morphine.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Fahad S. Alshehri, Badrah S. Alghamdi, Alqassem Y. Hakami, Abdullah A. Alshehri, Yusuf S. Althobaiti
Summary: The study found that melatonin can attenuate morphine-seeking behavior and reduce morphine-induced place preference.
BRAIN AND BEHAVIOR
(2021)
Article
Anesthesiology
Lisa Boinon, Jie Yu, Cynthia L. Madura, Aude Chefdeville, Douglas L. Feinstein, Aubin Moutal, Rajesh Khanna
Summary: CRMP2 is a key regulator of synaptic transmission and contributes to the transition of physiological pain into pathological pain.
Article
Anesthesiology
Laurent Martin, Mohab Ibrahim, Kimberly Gomez, Jie Yu, Song Cai, Lindsey A. Chew, Shreya S. Bellampalli, Aubin Moutal, Tally Largent-Milnes, Frank Porreca, Rajesh Khanna, Baldomero M. Olivera, Amol Patwardhan
Summary: This study investigates the mechanisms of CGX-induced antinociception in rodent models of inflammatory and neuropathic pain. It is found that CGX produces antinociception through activation of the neurotensin receptor 2 and R-type voltage-gated calcium channel in sensory neurons.
Article
Physiology
Aleyah E. Goins, Kimberly Gomez, Dongzhi Ran, Mitra Afaghpour-Becklund, Rajesh Khanna, Sascha R. A. Alles
Summary: Blocking Slc7a5 with JPH203 can alleviate chronic neuropathic pain, suggesting the important role of Slc7a5 in chronic pain.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Article
Biochemistry & Molecular Biology
Niloufar Mollasalehi, Liberty Francois-Moutal, David Porciani, Donald H. Burke, May Khanna
Summary: Neurodegenerative diseases (NDs) are characterized by progressive deterioration of neural structures, leading to cognitive or motor impairment. Effective therapies for common NDs such as Alzheimer's or Parkinson's disease are still lacking. This study explores the development of aptamers for targeting proteins associated with NDs and their potential applications in imaging, protein detection, and quantification, accelerating their clinical use for diagnosis and therapy.
NUCLEIC ACID THERAPEUTICS
(2022)
Article
Neurosciences
Xiangjin Kong, Yinping Li, Samantha Perez-Miller, Guoqing Luo, Qingyi Liao, Xiangyue Wu, Songping Liang, Cheng Tang, Rajesh Khanna, Zhonghua Liu
Summary: A novel NaVs antagonist, C65780, was characterized and found to inhibit pain signal transduction and neuronal excitability. It acts by trapping the sodium channels in the inactivated and slowly-recovering state to produce pain relief.
Article
Veterinary Sciences
Emad Khalilzadeh, Seyyedata Mousavi, Mahdi Dolatyarieslami, Reza Bahadori, Rajesh Khanna
Summary: The study aimed to establish a pain model in quail and evaluate the efficacy of opioid and non-steroidal anti-inflammatory drugs. The results showed that the formalin test was a reliable method for assessing tonic pain behavior in quail, with different effects observed at different stages with opioid and non-steroidal anti-inflammatory drugs.
VETERINARY ANAESTHESIA AND ANALGESIA
(2022)
Review
Biochemistry & Molecular Biology
Aida Calderon-Rivera, Santiago Loya-Lopez, Kimberly Gomez, Rajesh Khanna
Summary: This review synthesizes information on approximately 30 compounds derived from natural sources such as plants and fungi, and delineates their effects on VGSCs and VGCCs in human diseases, particularly in pain. Some natural products have entered clinical trials, while others are under investigation for their action mechanisms.
Review
Ophthalmology
Lindsey A. Chew, Albert S. Jun, Brad P. Barnett
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biology
Miranda L. Scalabrino, Mishek Thapa, Lindsey A. Chew, Esther Zhang, Jason Xu, Alapakkam P. Sampath, Jeannie Chen, Greg D. Field
Summary: The impact of progressive rod death on cone-mediated signaling remains unclear. Using a mouse model, researchers found that despite deterioration in cone morphology, the cone-mediated signaling among RGCs remained relatively stable throughout disease progression, until almost all rods had died and cones had completely lost outer segments.
Review
Biochemistry & Molecular Biology
Tam T. Quach, Harrison J. Stratton, Rajesh Khanna, Sabrina Mackey-Alfonso, Nicolas Deems, Jerome Honnorat, Kathrin Meyer, Anne-Marie Duchemin
Summary: This article provides an overview of neurodegenerative diseases and explores new therapeutic approaches. The accumulation of misfolded/aggregated proteins in the brain is a common pathological feature. The authors suggest a multiplexed gene transfer strategy to extend brain health span and improve chronic disease states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Neurosciences
Tyler S. Nelson, Rajesh Khanna
Article
Cell Biology
Tatiana Brustovetsky, Rajesh Khanna, Nickolay Brustovetsky
Summary: Mitochondrial bioenergetics and dynamics, specifically alterations in morphology and motility, play vital roles in the response of neurons to energy requirements in health and Alzheimer's disease (AD). The hyperphosphorylation of collapsin response mediator protein 2 (CRMP2) in AD disrupts its interaction with proteins regulating mitochondrial morphology and motility, resulting in increased Drp1 recruitment to mitochondria, augmented mitochondrial fragmentation, and reduced mitochondrial motility. The small molecule (S)-lacosamide ((S)-LCM) decreases CRMP2 phosphorylation, restores its interaction with related proteins, and improves mitochondrial dynamics and neuronal survival in AD.
Article
Chemistry, Multidisciplinary
Ya-ming Xu, E. M. Kithsiri Wijeratne, Aida Calderon-Rivera, Santiago Loya-Lopez, Samantha Perez-Miller, Rajesh Khanna, A. A. Leslie Gunatilaka
Summary: Four new triterpenes were isolated from Parthenium incanum and their structures were determined. These compounds were found to decrease the excitability of dorsal root ganglia neurons. The binding sites of these compounds in pain-relevant voltage-gated sodium and calcium channels were evaluated, and preliminary structure-activity relationships were established.
Article
Integrative & Complementary Medicine
Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Eun Jin Ahn, Fletcher A. White, Ye Jin Cho, Chong Wha Baek, Yong Hun Jung, Ji Wung Kwon
Summary: This study evaluated the efficacy of immature Rubus occidentalis extract (iROE) on acid-induced hyperalgesia and investigated the mechanism involved. The antihyperalgesic effect of immature and mature ROEs was compared.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)