Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats

AAV8gfp preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection

(2012) Steven J. Jacques et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The AAV Vector Toolkit: Poised at the Clinical Crossroads

(2012) Aravind Asokan et al.   MOLECULAR THERAPY

In Vivo Gene Knockdown in Rat Dorsal Root Ganglia Mediated by Self-Complementary Adeno-Associated Virus Serotype 5 Following Intrathecal Delivery

(2012) Qinghao Xu et al.   PLoS One

Intrathecal shRNA-AAV9 Inhibits Target Protein Expression in the Spinal Cord and Dorsal Root Ganglia of Adult Mice

(2012) Takashi Hirai et al.   Human Gene Therapy Methods

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver

(2011) A. T. Martino et al.   BLOOD

Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs

(2011) T Federici et al.   GENE THERAPY

Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration

(2011) J Homs et al.   GENE THERAPY

Comparison of Adeno-Associated Viral Vector Serotypes for Spinal Cord and Motor Neuron Gene Delivery

(2011) Brooke R. Snyder et al.   HUMAN GENE THERAPY

Direct injection into the dorsal root ganglion: Technical, behavioral, and histological observations

(2011) Gregory Fischer et al.   JOURNAL OF NEUROSCIENCE METHODS

Lentiviral Gene Transfer into the Dorsal Root Ganglion of Adult Rats

(2011) gwei Yu et al.   Molecular Pain

Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric Disorders

(2011) Adam K Bevan et al.   MOLECULAR THERAPY

Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal Models

(2011) Kleopatra Rapti et al.   MOLECULAR THERAPY

Innate Immune Responses to AAV Vectors

(2011) Geoffrey L. Rogers et al.   Frontiers in Microbiology

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors

(2010) N Zeltner et al.   GENE THERAPY

Optimized Transduction of Human Monocyte-Derived Dendritic Cells by Recombinant Adeno-Associated Virus Serotype 6

(2010) James E. Ussher et al.   HUMAN GENE THERAPY

Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

(2010) Martin Lock et al.   HUMAN GENE THERAPY

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY

Differential Adeno-Associated Virus Mediated Gene Transfer to Sensory Neurons following Intrathecal Delivery by Direct Lumbar Puncture

(2010) Lucy Vulchanova et al.   Molecular Pain

AAV Provides an Alternative for Gene Therapy of the Peripheral Sensory Nervous System

(2010) Andreas S Beutler   MOLECULAR THERAPY

Comparison of AAV Serotypes for Gene Delivery to Dorsal Root Ganglion Neurons

(2010) Matthew RJ Mason et al.   MOLECULAR THERAPY

Transient Demyelination Increases the Efficiency of Retrograde AAV Transduction

(2010) Edmund R Hollis et al.   MOLECULAR THERAPY

Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing rAAV2

(2009) Jaehyung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

(2009) F. Mingozzi et al.   BLOOD

Posttranscriptional Regulatory Elements Enhance Antigen Expression and DNA Vaccine Efficacy

(2009) Jing Sun et al.   DNA AND CELL BIOLOGY

AAV for pain: steps towards clinical translation

(2009) A S Beutler et al.   GENE THERAPY

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

(2009) E Ayuso et al.   GENE THERAPY

Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1

(2009) Naotaka Iwamoto et al.   JOURNAL OF GENE MEDICINE

Learned Avoidance From Noxious Mechanical Simulation But Not Threshold Semmes Weinstein Filament Stimulation After Nerve Injury in Rats

(2009) Hsiang-En Wu et al.   JOURNAL OF PAIN

Recombinant Adeno-Associated Virus Serotype 6 (rAAV2/6)-Mediated Gene Transfer to Nociceptive Neurons through Different Routes of Delivery

(2009) Chris Towne et al.   Molecular Pain

Molecular Engineering of Viral Gene Delivery Vehicles

(2008) David V. Schaffer et al.   Annual Review of Biomedical Engineering

Manufacturing and characterizing AAV-based vectors for use in clinical studies

(2008) J F Wright   GENE THERAPY

Molecular and Cellular Limits to Somatosensory Specificity

(2008) Carlos Belmonte et al.   Molecular Pain

Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain

(2008) B. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

(2007) Ronald L Klein et al.   MOLECULAR THERAPY