Article
Agronomy
Piera Iommelli, Federico Infascelli, Nadia Musco, Micaela Grossi, Maria Ferrara, Fiorella Sarubbi, Biagio D'Aniello, Pietro Lombardi, Raffaella Tudisco
Summary: This study compared the effects of two different diets on buffalo meat quality and SCD gene expression in adipose tissue, revealing important differences between buffalo and bovine species, highlighting the need for specific research on buffalo.
Article
Medicine, Research & Experimental
Gang Li, Xin Li, Iqbal Mahmud, Jazmin Ysaguirre, Baharan Fekry, Shuyue Wang, Bo Wei, Kristin L. Eckel-Mahan, Philip L. Lorenzi, Richard Lehner, Kai Sun
Summary: This study found that carboxylesterase 1 (CES1) is expressed at various levels in hepatocellular carcinoma (HCC). Inhibition of CES1 leads to altered lipid profiles and impaired mitochondrial function. CES1 inhibition also reduces lipid signaling molecules and downregulates SCD, a crucial gene involved in tumor progression and chemoresistance. Targeting the CES1-PPAR alpha/gamma-SCD axis sensitizes HCC cells to cisplatin treatment and slows down the growth of HCC xenograft tumors in mice. These findings suggest CES1 as a promising therapeutic target for HCC treatment.
Article
Endocrinology & Metabolism
Xin You, Jingyu Tian, Hui Zhang, Yunhua Guo, Jing Yang, Chaofeng Zhu, Ming Song, Peng Wang, Zexian Liu, John Cancilla, Wenhua Lu, Christophe Glorieux, Shijun Wen, Hongli Du, Peng Huang, Yumin Hu
Summary: The study revealed an association between reduced mitochondrial aconitase (ACO2) levels in colorectal cancer (CRC) with advanced disease stage and shorter patient survival. Knockdown of ACO2 promoted cell proliferation and tumor formation, while overexpression of ACO2 restrained tumor growth. Loss of ACO2 led to decreased TCA cycle intermediates, increased glycolysis, and elevated citrate flux for fatty acid synthesis.
MOLECULAR METABOLISM
(2021)
Article
Oncology
Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera, Johannes Swinnen
Summary: The study identified distinct lipid features in prostate cancer tissues, including enhanced fatty acid synthesis and elongation. Targeting the regulation of lipid composition may be a crucial therapeutic approach for prostate cancer.
Article
Chemistry, Analytical
Shanshan Jia, Shao Chang, Lin Zhang, Zhengwei Gui, Linhui Liu, Zhenglan Ma, Shuyu Li, Xingchen Huang, Hongying Zhong
Summary: A photocatalytic technique has been developed for in situ mass spectrometric identification and spatial imaging of positional isomers of lipids. It involves the use of gold nanowires to transfer plasmonic hot electrons, generating hydroxyl radicals that cause bond cleavages. The technique can determine the locations of C=C bonds through diagnostic fragment ions produced by collision or auto-fragmentation.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Waseem K. Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J. Rhodes, Vikram Khurana, Robert H. Scannevin, Chee Yeun Chung
Summary: Currently, there is no preventive or disease-modifying therapy available for Parkinson's Disease (PD). The failure of clinical trials calls for a re-evaluation of pre-clinical models that better replicate disease mechanisms and predict clinical outcomes. Patient-derived induced pluripotent stem cell (iPSC) models have recently emerged as attractive options to mimic disease-relevant neuropathology in vitro without artificially overexpressing disease-related proteins. In this study, iPSCs derived from early-onset PD patients with specific mutations were utilized to generate a three-dimensional cortical neurosphere model. The model showed alterations in fatty acid profiles and increased levels of pathogenic proteins, which could be attenuated by a small molecule inhibitor. These findings suggest that the 3D cortical neurosphere model is a useful tool for investigating PD and testing potential therapeutics.
Article
Biochemistry & Molecular Biology
Bing-Yen Wang, Yuan-Yen Chang, Li-Yen Shiu, Yi-Ju Lee, Yu-Wei Lin, Yu-Shen Hsu, Hsin-Ting Tsai, Sung-Po Hsu, Li-Jen Su, Meng-Hsiu Tsai, Jing-Hong Xiao, Jer-An Lin, Chang-Han Chen
Summary: This study systematically investigated the expression patterns and clinical outcomes of SCD1 in multiple human cancers and found that SCD1 is dysregulated in several types of cancers and acts as a diagnostic biomarker. Using ESCC as an example, it was found that SCD1 is upregulated in ESCC tumor tissues and is associated with clinicopathological characteristics and poor survival outcomes. Additionally, the study revealed the potential therapeutic target of the miR-181a-5p/SCD1 axis for ESCC treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Cheng Chen, Xin Xin, Qian Liu, Hua-Jie Tian, Jing-Hua Peng, Yu Zhao, Yi-Yang Hu, Qin Feng
Summary: The study demonstrates that the GC combination has a significant anti-lipogenesis effect on NAFLD, improving symptoms by inhibiting hepatic SCD-1 and the DNL process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Julia H. Goedecke, Elin Chorell, Paul J. van Jaarsveld, Ulf Riserus, Tommy Olsson
Summary: This study examined ethnic differences in serum fatty acid composition and desaturase indices among black and white South African women, finding that despite lower whole-body insulin sensitivity in black women, they exhibited a fatty acid pattern typically associated with higher insulin sensitivity in European populations. The results suggest that genetic factors may play a role in influencing fatty acid metabolism and insulin sensitivity among different ethnic groups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Takanori Hiraide, Yoshifumi Morita, Makoto Horikawa, Eiji Sugiyama, Tomohito Sato, Tomoaki Kahyo, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Takanori Sakaguchi, Hiroyuki Konno, Mitsutoshi Setou, Hiroya Takeuchi
Summary: This study found that the ratio of saturated to monounsaturated fatty acids in cellular membranous phospholipids affects sensitivity to chemotherapeutic agents.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Rui-He Zheng, Yi-Bo Zhang, Fu-Nan Qiu, Zhao-Hui Liu, Yun Han, Rui Huang, Yun Zhao, Peijie Yao, Yan Qiu, Jie Ren
Summary: SCD1 deficiency induces apoptosis in colorectal cancer cells by promoting ceramide de novo synthesis, with NF-kappa B pathway playing a crucial role in this process. Reduced levels of MUFAs contribute to the effects of SCD1 inhibition on cancer cell growth and gene expression.
CANCER BIOLOGY & THERAPY
(2021)
Article
Ophthalmology
Chunyan Ji, Yuli Guo, Ying Liu, Sennan Xu, Sichen Zhao, Xin Luo, Funan Qiu, Rui Huang, Qingyan Xu, Ruihe Zheng, Miao Xia, Yun Zhao, Jie Ren, Yan Qiu
Summary: High expression of SCD1 in meibomian glands leads to lipid metabolism dysfunction, while inhibition of de novo ceramide biosynthesis could be a potential new clinical approach to treating meibomian gland dysfunction.
Article
Biochemistry & Molecular Biology
Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng, Jerome Baudry
Summary: SCD1 is a key metabolic protein involved in converting saturated fatty acids to monounsaturated fatty acids, with overactivity linked to diseases. Computational molecular dynamics study reveals interactions between SCD1, substrates, and products, providing insights for drug discovery.
Article
Endocrinology & Metabolism
Yiruo Ma, Siyi Shen, Ying Yan, Shengjie Zhang, Shengnan Liu, Zhili Tang, Jing Yu, Mei Ma, Zhoumin Niu, Zhuoyang Li, Yuting Wu, Lin Zhao, Zhiqiang Lu, Chunchun Wei, Weiping J. Zhang, Ying Xue, Qiwei Zhai, Yu Li, Cheng Hu, Jingjing Jiang, Yuying Li, Hao Ying
Summary: Thyroid hormone (TH) plays a crucial role in energy metabolism and systemic homeostasis by regulating adipose tissues. The active form of TH, triiodothyronine (T3), affects inguinal white adipose tissue (iWAT) and whole-body metabolism. Through the study of mice lacking adipocyte TH receptors (TR) alpha or TR beta, it was found that TR beta is the major mediator of T3's effects on iWAT, influencing metabolic pathways related to glucose uptake and use, fatty acid synthesis, and thermogenesis. Adipocyte TR beta deficiency in mice leads to susceptibility to diet-induced obesity and metabolic dysregulation, highlighting its potential as a target for metabolic diseases.
Article
Cell Biology
Reuben S. E. Young, Andrew P. Bowman, Elizabeth D. Williams, Kaylyn D. Tousignant, Charles L. Bidgood, Venkateswara R. Narreddula, Rajesh Gupta, David L. Marshall, Berwyck L. J. Poad, Colleen C. Nelson, Shane R. Ellis, Ron M. A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Summary: Canonical fatty acid metabolism describes specific enzyme-substrate interactions resulting in well-defined products. Profiling of lipids in prostate cancer cell lines revealed unusual unsaturated fatty acids not described by canonical pathways. Direct desaturation of fatty acids by FADS2 generated new unsaturated fatty acid families rarely reported in human-derived cells, with functional roles in membrane structure and signaling.
Article
Pathology
Heng-feng Yuan, Christina Von Roemeling, Hui-di Gao, Jing Zhang, Chang-an Guo, Zuo-qin Yan
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2015)
Article
Endocrinology & Metabolism
Christina A. von Roemeling, Laura A. Marlow, Anthony B. Pinkerton, Angela Crist, James Miller, Han W. Tun, Robert C. Smallridge, John A. Copland
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2015)
Article
Oncology
Qiu Yushi, Zhimin Li, Christina A. Von Roemeling, Heike Doeppler, Laura A. Marlow, Betty Y. S. Kim, Derek C. Radisky, Peter Storz, John A. Copland, Han W. Tun
Article
Multidisciplinary Sciences
Heng-feng Yuan, Von Roemeling Christina, Chang-an Guo, Yi-wei Chu, Rong-hua Liu, Zuo-qin Yan
SCIENTIFIC REPORTS
(2016)
Article
Nanoscience & Nanotechnology
Hengfeng Yuan, Wen Jiang, Christina A. von Roemeling, Yaqing Qie, Xiujie Liu, Yuanxin Chen, Yifan Wang, Robert E. Wharen, Kyuson Yun, Guojun Bu, Keith L. Knutson, Betty Y. S. Kim
NATURE NANOTECHNOLOGY
(2017)
Editorial Material
Biotechnology & Applied Microbiology
Wen Jiang, Hengfeng Yuan, Charles K. Chan, Christina A. von Roemeling, Zuoqin Yan, Irving L. Weissman, Betty Y. S. Kim
NATURE REVIEWS DRUG DISCOVERY
(2017)
Review
Biotechnology & Applied Microbiology
Christina von Roemeling, Wen Jian, Charles K. Chan, Irving L. Weissman, Betty Y. S. Kim
TRENDS IN BIOTECHNOLOGY
(2017)
Article
Oncology
Christina A. von Roemeling, Thomas R. Caulfield, Laura Marlow, Ilah Bok, Jiang Wen, James L. Miller, Robert Hughes, Lori Hazlehurst, Anthony B. Pinkerton, Derek C. Radisky, Han W. Tun, Yon Son Betty Kim, Amy L. Lane, John A. Copland
Article
Engineering, Biomedical
Wen Jiang, Christina A. von Roemeling, Yuanxin Chen, Yaqing Qie, Xiujie Liu, Jianzhu Chen, Betty Y. S. Kim
NATURE BIOMEDICAL ENGINEERING
(2017)
Article
Oncology
Christina A. von Roemeling, Derek C. Radisky, Laura A. Marlow, Simon J. Cooper, Stefan K. Grebe, Panagiotis Z. Anastasiadis, Han W. Tun, John A. Copland
Article
Oncology
Marie N. Becker, Kevin J. Wu, Laura A. Marlow, Pamela A. Kreinest, Christina A. vonRoemeling, John A. Copland, Christopher R. Williams
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2014)
Article
Multidisciplinary Sciences
Yaqing Qie, Hengfeng Yuan, Christina A. von Roemeling, Yuanxin Chen, Xiujie Liu, Kevin D. Shih, Joshua A. Knight, Han W. Tun, Robert E. Wharen, Wen Jiang, Betty Y. S. Kim
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Ligia I. Bastea, Geou-Yarh Liou, Veethika Pandey, Alicia K. Fleming, Christina A. von Roemeling, Heike Doeppler, Zhimin Li, Yushi Qiu, Brandy Edenfield, John A. Copland, Han W. Tun, Peter Storz
Article
Chemistry, Multidisciplinary
Yuanxin Chen, Xiujie Liu, Hengfeng Yuan, Zhaogang Yang, Christina A. von Roemeling, Yaqing Qie, Hai Zhao, Yifan Wang, Wen Jiang, Betty Y. S. Kim