MYC modulators in cancer: a patent review

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells

(2019) Svitlana Melnik et al.   Stem Cell Research & Therapy

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

(2019) Marie-Eve Beaulieu et al.   Science Translational Medicine

A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer

(2019) Shanshan Bai et al.   ONCOGENE

Investigation of expressions of PDK 1, PLK 1 and c‐Myc in diffuse large B‐cell lymphoma

(2019) Yuhua Feng et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

MYC in Germinal Center‐derived lymphomas: Mechanisms and therapeutic opportunities

(2019) Andrea Bisso et al.   IMMUNOLOGICAL REVIEWS

Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer

(2019) Yanyan Gao et al.   FEBS Journal

KLF5 and MYC modulated LINC00346 contributes to gastric cancer progression through acting as a competing endogeous RNA and indicates poor outcome

(2019) Tong-peng Xu et al.   CELL DEATH AND DIFFERENTIATION

Inflammation‐dependent overexpression of c‐Myc enhances CRL4 DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis‐associated cancer

(2019) Hong Liu et al.   JOURNAL OF PATHOLOGY

Is Myc an Important Biomarker? Myc Expression in Immune Disorders and Cancer

(2018) Shivtia Trop-Steinberg et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Synthesis, cytotoxicity and anti-metastatic properties of new pyridyl-thiazole arene ruthenium(II) complexes

(2018) Li Wang et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Synthetic Molecules for Disruption of the MYC Protein-Protein Interface

(2018) Nicholas T Jacob et al.   BIOORGANIC & MEDICINAL CHEMISTRY

c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs

(2018) Wen Luo et al.   CELL DEATH AND DIFFERENTIATION

Che‐1 is targeted by c‐Myc to sustain proliferation in pre‐B‐cell acute lymphoblastic leukemia

(2018) Valentina Folgiero et al.   EMBO REPORTS

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

(2018) Marco Franceschin et al.   MOLECULES

The Expanding World of N-MYC–Driven Tumors

(2018) David S. Rickman et al.   Cancer Discovery

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

(2018) Alina Castell et al.   Scientific Reports

Functional interplay between c‐Myc and Max in B lymphocyte differentiation

(2018) Mercedes Pérez‐Olivares et al.   EMBO REPORTS

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

(2018) Matteo Caforio et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FBXW7: a critical tumor suppressor of human cancers

(2018) Chien-Hung Yeh et al.   Molecular Cancer

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

(2018) Patrick A. Carroll et al.   Frontiers of Medicine

The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target

(2018) Lydia Brandl et al.   MEDICAL ONCOLOGY

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation

(2017) Stefano de Pretis et al.   GENOME RESEARCH

Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells

(2017) Dongyeon Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction

(2017) Yu-Qing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex

(2017) Chan Shan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry

(2017) De-Ying Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis

(2017) Antonio Cigliano et al.   Oncotarget

MYC Modulation around the CDK2/p27/SKP2 Axis

(2017) Per Hydbring et al.   Genes

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Approach to the diagnosis and treatment of high-grade B-cell lymphomas withMYCandBCL2and/orBCL6rearrangements

(2016) Pierre Sesques et al.   BLOOD

MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system

(2016) Sehui Kim et al.   BMC CANCER

Recent advances in targeting mTOR signaling pathway using small molecule inhibitors

(2016) Azam Roohi et al.   JOURNAL OF DRUG TARGETING

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1

(2016) Caleb Sutherland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

(2016) Mark W. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects

(2016) Hidayatullah Munshi et al.   OncoTargets and Therapy

BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis

(2016) Laia Richart et al.   Nature Communications

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

(2015) Kenneth M. Felsenstein et al.   ACS Chemical Biology

Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents

(2015) Gui-Zhen Wang et al.   CANCER SCIENCE

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

Anti-proliferative effects of γ-tocotrienol are associated with suppression of c-Myc expression in mammary tumour cells

(2015) P. Parajuli et al.   CELL PROLIFERATION

MYC-Mediated Synthetic Lethality for Treating Tumors

(2015) Xin Li et al.   CURRENT CANCER DRUG TARGETS

Selection-based discovery of macrocyclic peptides for the next generation therapeutics

(2015) Tomomi Morioka et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

G4-associated human diseases

(2015) N. Maizels   EMBO REPORTS

Ibrutinib in B lymphoid malignancies

(2015) Mitchell R Smith   EXPERT OPINION ON PHARMACOTHERAPY

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

(2015) Kwan-Young Jung et al.   JOURNAL OF MEDICINAL CHEMISTRY

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

(2015) Dharmendra Dingar et al.   Journal of Proteomics

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Chemical intervention of the NM23-H2 transcriptional programme onc-MYCvia a novel small molecule

(2015) Chan Shan et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Far upstream element-binding protein 1 (FUBP1) is a potential c-Myc regulator in esophageal squamous cell carcinoma (ESCC) and its expression promotes ESCC progression

(2015) Lei Yang et al.   TUMOR BIOLOGY

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity

(2015) Cristian Turato et al.   Scientific Reports

A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells

(2015) Deepanjan Panda et al.   Scientific Reports

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

(2015) Jutta Wanner et al.   PLoS One

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer

(2015) Ho Kyung Seo et al.   Oncotarget

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential

(2015) Philipp Raffeiner et al.   Oncotarget

PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation

(2015) Youlin Yao et al.   Oncotarget

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc-Max Dimerization

(2014) Jay Chauhan et al.   ChemMedChem

Ruthenium(II) polypyridyl complexes: Cellular uptake, cell image and apoptosis of HeLa cancer cells induced by double targets

(2014) Qianqian Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium(II) complexes as apoptosis inducers by stabilizing c-myc G-quadruplex DNA

(2014) Zhao Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer

(2014) Dimitris Stellas et al.   JNCI-Journal of the National Cancer Institute

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells

(2014) Jiandong Wang et al.   Journal of Translational Medicine

Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies

(2014) Valentina Rapozzi et al.   Molecular Cancer

Inhibitor of MYC identified in a Krohnke pyridine library

(2014) J. R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven Cancers

(2014) S. Cermelli et al.   Cold Spring Harbor Perspectives in Medicine

Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription

(2013) Siqi Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer

(2013) Zi Liu et al.   CARCINOGENESIS

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

Intravesical Instillation of c-MYC Inhibitor KSI-3716 Suppresses Orthotopic Bladder Tumor Growth

(2013) Kyung-Chae Jeong et al.   JOURNAL OF UROLOGY

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Benzofuroquinoline Derivatives Had Remarkable Improvement of their Selectivity for Telomeric G-Quadruplex DNA over Duplex DNA upon Introduction of Peptidyl Group

(2012) Yi Long et al.   BIOCONJUGATE CHEMISTRY

Pharmacophore identification of c-Myc inhibitor 10074-G5

(2012) Jeremy L. Yap et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Macrocyclic G-Quadruplex Ligands

(2012) M. C. Nielsen et al.   CURRENT MEDICINAL CHEMISTRY

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

c-Myc Overexpression Promotes Osteosarcoma Cell Invasion Via Activation of MEK-ERK Pathway

(2012) Gang Han et al.   ONCOLOGY RESEARCH

The Myc-ARF-Egr1 pathway

(2011) David N. Boone et al.   CELL CYCLE

CYCLINg through transcription: Post-translational modifications of P-TEFb regulate transcription elongation

(2010) Sungyoo Cho et al.   CELL CYCLE

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

(2010) D. M. Clausen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest

(2010) Kyung-Chae Jeong et al.   Molecular BioSystems

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex

(2010) Linsey Reavie et al.   NATURE IMMUNOLOGY

The c-MYC NHE III1: Function and Regulation

(2009) Verónica González et al.   Annual Review of Pharmacology and Toxicology

Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines

(2009) Yoko Mikami-Terao et al.   EXPERIMENTAL EYE RESEARCH

G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells

(2009) W.-J. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

(2008) Yan Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-NPositive Charge on Quadruplex Binding Affinity and Cell Proliferation

(2008) Yu-Jing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents

(2008) D. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Transcription-independent functions of MYC: regulation of translation and DNA replication

(2008) Michael D. Cole et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antitumor activity of G-quadruplex–interactive agent TMPyP4 in K562 leukemic cells

(2007) Yoko Mikami-Terao et al.   CANCER LETTERS