MYC Modulation around the CDK2/p27/SKP2 Axis

Inhibition of Akt and other AGC kinases: A target for clinical cancer therapy?

(2018) Vincent Prêtre et al.   SEMINARS IN CANCER BIOLOGY

Ribosomal S6 kinase (RSK) modulators: a patent review

(2016) Katarzyna A. Ludwik et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

RB1: a prototype tumor suppressor and an enigma

(2016) Nicholas J. Dyson   GENES & DEVELOPMENT

Interaction of Gcn4 with target gene chromatin is modulated by proteasome function

(2016) Gregory C. Howard et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation

(2016) Laura A. Jaenicke et al.   MOLECULAR CELL

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

(2016) Dai Horiuchi et al.   NATURE MEDICINE

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

(2016) Per Hydbring et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo

(2016) Junko Odajima et al.   PLoS Genetics

Myc and its interactors take shape

(2015) William B. Tu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Small-molecule inhibitors of the Myc oncoprotein

(2015) Steven Fletcher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2

(2015) Azfar Jamal et al.   CELL CYCLE

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

(2015) Guoxiang Jin et al.   MOLECULAR CELL

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

(2015) Szu-Wei Lee et al.   MOLECULAR CELL

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers

(2015) Xiaoyang Zhang et al.   NATURE GENETICS

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer

(2015) E G Seviour et al.   ONCOGENE

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis

(2015) Dazhi Xu et al.   Nature Communications

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

(2015) A. Wiegering et al.   Cancer Discovery

Targeting MYC Translation in Colorectal Cancer

(2015) A. Castell et al.   Cancer Discovery

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

(2015) Wenfu Lu et al.   Oncotarget

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation

(2015) Fuad Bahram et al.   Oncotarget

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

(2015) Kevin Myant et al.   Cell Reports

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

(2015) Juan M. Caraballo et al.   Oncotarget

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Sin3b Interacts with Myc and Decreases Myc Levels

(2014) Pablo Garcia-Sanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SIRT1 Inactivation Evokes Antitumor Activities in NSCLC through the Tumor Suppressor p27

(2014) Lijia Zhu et al.   MOLECULAR CANCER RESEARCH

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

(2014) Apolinar Maya-Mendoza et al.   Molecular Oncology

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

(2014) Arianna Sabò et al.   NATURE

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification

(2014) A. Ullius et al.   NUCLEIC ACIDS RESEARCH

Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells

(2014) R S Watnick et al.   ONCOGENE

SUMOylation of Myc-Family Proteins

(2014) Arianna Sabò et al.   PLoS One

Identification of c-MYC SUMOylation by Mass Spectrometry

(2014) Manpreet Kalkat et al.   PLoS One

Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer

(2014) M. Janghorban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

Therapeutic Strategies to Inhibit MYC

(2014) M. R. McKeown et al.   Cold Spring Harbor Perspectives in Medicine

MYC and Transcription Elongation

(2014) P. B. Rahl et al.   Cold Spring Harbor Perspectives in Medicine

Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors

(2013) Hongling Zhao et al.   CANCER CELL

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

(2013) A. R. Wasylishen et al.   CANCER RESEARCH

Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target

(2013) A. Khanna et al.   CANCER RESEARCH

Identification of small molecule inhibitors of p27Kip1ubiquitination by high-throughput screening

(2013) Li-Ching Ooi et al.   CANCER SCIENCE

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

CDK-mediated activation of the SCFFBXO28ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

(2013) Diana Cepeda et al.   EMBO Molecular Medicine

Inhibitors of SCF-Skp2/Cks1 E3 Ligase Block Estrogen-Induced Growth Stimulation and Degradation of Nuclear p27kip1: Therapeutic Potential for Endometrial Cancer

(2013) Savvas C. Pavlides et al.   ENDOCRINOLOGY

Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

(2013) A. S. Farrell et al.   MOLECULAR AND CELLULAR BIOLOGY

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

MYC activity is negatively regulated by a C-terminal lysine cluster

(2013) A R Wasylishen et al.   ONCOGENE

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

(2013) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skp2-RNAi suppresses proliferation and migration of gallbladder carcinoma cells by enhancing p27 expression

(2013) Bin Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Ubiquitin and Proteasomes in Transcription

(2012) Fuqiang Geng et al.   Annual Review of Biochemistry

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation

(2012) Lily Wu et al.   CHEMISTRY & BIOLOGY

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

(2012) Juan Wu et al.   MOLECULAR CELL

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

(2012) Jeffrey Buis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diversity within the pRb pathway: is there a code of conduct?

(2012) S Munro et al.   ONCOGENE

Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

(2012) I. K. Sur et al.   SCIENCE

Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland

(2011) X. Wang et al.   CANCER RESEARCH

The Two Faces of Interferon-  in Cancer

(2011) M. R. Zaidi et al.   CLINICAL CANCER RESEARCH

Regulation of gene transcription by the oncoprotein MYC

(2011) Bernhard Lüscher et al.   GENE

SKP2 Oncogene Is a Direct MYC Target Gene and MYC Down-regulates p27KIP1through SKP2 in Human Leukemia Cells

(2011) Gabriel Bretones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of MCM3 Protein by Cyclin E/Cyclin-dependent Kinase 2 (Cdk2) Regulates Its Function in Cell Cycle

(2011) Junhui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes

(2011) R Pippa et al.   ONCOGENE

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

(2011) A. Menssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence

(2011) Lars-Gunnar Larsson   SEMINARS IN CANCER BIOLOGY

Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

(2011) Chia-Hsin Chan et al.   TheScientificWorldJOURNAL

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

(2010) Kavya Rakhra et al.   CANCER CELL

Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair

(2010) K. R. Luoto et al.   CANCER RESEARCH

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1and p57Kip2CDK inhibitors

(2010) Zhimin Lu et al.   CELL CYCLE

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy

(2010) Lars-Gunnar Larsson et al.   EXPERIMENTAL CELL RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Cks1, Cdk1, and the 19S Proteasome Collaborate To Regulate Gene Induction-Dependent Nucleosome Eviction in Yeast

(2010) S. Chaves et al.   MOLECULAR AND CELLULAR BIOLOGY

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine

(2010) D Athineos et al.   ONCOGENE

LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription

(2010) S Amente et al.   ONCOGENE

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage

(2010) Lina Guerra et al.   PLoS One

Clinical Use of Interferon-γ

(2009) Catriona H.T. Miller et al.   Annals of the New York Academy of Sciences

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc

(2009) Hugh K Arnold et al.   EMBO JOURNAL

The 19 S Proteasome Subcomplex Establishes a Specific Protein Interaction Network at the Promoter for Stimulated Transcriptional Initiationin Vivo

(2009) Shivani Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry

(2009) Li-Chiou Chuang et al.   MOLECULAR CELL

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

(2009) Stefano Campaner et al.   NATURE CELL BIOLOGY

c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress

(2009) Kristin Robinson et al.   PLoS One

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

(2009) J. J. Molenaar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc-Mediated Transcriptional Repression by Recruitment of Histone Deacetylase

(2008) J. F. Kurland et al.   CANCER RESEARCH

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Post-translational regulation of the tumor suppressor p27KIP1

(2008) J. Vervoorts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Cdk5-mediated Phosphorylation of c-Myc on Ser-62 Is Essential in Transcriptional Activation of Cyclin B1 by Cyclin G1

(2008) Haeng Ran Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27Kip1 cyclin dependent kinase inhibitor

(2008) Vidyalakshmi Chandramohan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY

Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

(2008) Ludger Hauck et al.   NATURE MEDICINE

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

(2008) D Zhuang et al.   ONCOGENE

Pim kinase-dependent inhibition of c-Myc degradation

(2008) Y Zhang et al.   ONCOGENE

Identification of CDK2 substrates in human cell lysates

(2008) Yong Chi et al.   GENOME BIOLOGY