The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

An in silico proteomics screen to predict and prioritize protein–protein interactions dependent on post-translationally modified motifs

(2018) Anna M Schmoker et al.   BIOINFORMATICS

Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1

(2018) Cristina Failla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pancreatic cancer survival analysis defines a signature that predicts outcome

(2018) Pichai Raman et al.   PLoS One

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes

(2018) Chenchen Yang et al.   Epigenomics

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Modulation of VEGF receptor 2 signaling by protein phosphatases

(2017) Federico Corti et al.   PHARMACOLOGICAL RESEARCH

SEMA3A partially reverses VEGF effects through binding to neuropilin-1

(2017) Bruna Palodetto et al.   Stem Cell Research

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

(2017) Nicholas Johnson et al.   Scientific Reports

Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics

(2017) Spencer B. Mamer et al.   Scientific Reports

The neuropilin-like protein ESDN regulates insulin signaling and sensitivity

(2016) Xuan Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2)

(2016) Peter J. Noy et al.   FASEB JOURNAL

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrates and physiological functions of secretase rhomboid proteases

(2016) Viorica L. Lastun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Discoidin Domains as Emerging Therapeutic Targets

(2016) Bruno O. Villoutreix et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

(2016) Lina Wunderle et al.   Scientific Reports

SEMA4B inhibits growth of non-small cell lung cancer in vitro and in vivo

(2015) Hong Jian et al.   CELLULAR SIGNALLING

Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium

(2015) Roberto Scirpo et al.   HEPATOLOGY

A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus

(2014) D.-C. Cai et al.   GENES BRAIN AND BEHAVIOR

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

(2014) Haizhong Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

RHBDL2 Is a Critical Membrane Protease for Anoikis Resistance in Human Malignant Epithelial Cells

(2014) Tsung-Lin Cheng et al.   TheScientificWorldJOURNAL

Both LCCL-domains of human CRISPLD2 have high affinity for lipid A

(2013) Viktor Vásárhelyi et al.   BIOCHIMIE

Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL

(2013) Tyler M. Aten et al.   FEBS LETTERS

Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis

(2013) Lei Nie et al.   JOURNAL OF CLINICAL INVESTIGATION

Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARγ and TNFα Signaling

(2013) Stefano Maria Pagnotta et al.   PLoS One

Neuropilin signalling in vessels, neurons and tumours

(2013) Claudio Raimondi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Parallels between Neural and Vascular Development

(2013) A. Eichmann et al.   Cold Spring Harbor Perspectives in Medicine

Expression of AP-2α, AP-2γ and ESDN in primary melanomas: Correlation with histopathological features and potential prognostic value

(2012) Simona Osella-Abate et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Potential Association of DCBLD2 Polymorphisms with Fall Rates of FEV1 by Aspirin Provocation in Korean Asthmatics

(2012) Tae-Joon Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

DCBLD2 Gene Variations Correlate with Nasal Polyposis in Korean Asthma Patients

(2012) Charisse Flerida A. Pasaje et al.   LUNG

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

(2012) Qing Lan et al.   NATURE GENETICS

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression

(2012) L Sabatino et al.   ONCOGENE

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

(2012) Matthew W. Parker et al.   PLoS One

CD73 promotes tumor growth and metastasis

(2012) Bin Zhang   OncoImmunology

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

Functions of Rhomboid Family Protease RHBDL2 and Thrombomodulin in Wound Healing

(2011) Tsung-Lin Cheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

(2010) Francesca Orso et al.   BMC GENOMICS

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Long signal peptides of RGMa and DCBLD2 are dissectible into subdomains according to the NtraC model

(2010) Eduard Resch et al.   Molecular BioSystems

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome

(2010) Massimo Pancione et al.   PLoS One

PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle

(2009) A. H. V. Remels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination

(2009) Xiaojia Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NCBI BioSystems database

(2009) Lewis Y. Geer et al.   NUCLEIC ACIDS RESEARCH

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis

(2008) Elena Geretti et al.   ANGIOGENESIS

Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins

(2008) Marie N. O'Connor et al.   BLOOD

Identification of novel neuroendocrine-specific tumour genes

(2008) E Hofsli et al.   BRITISH JOURNAL OF CANCER

Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis

(2008) B. Sehat et al.   CANCER RESEARCH

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

AP-2α and AP-2γ regulate tumor progression via specific genetic programs

(2008) Francesca Orso et al.   FASEB JOURNAL

The Human Protein Atlas-a tool for pathology

(2008) F Pontén et al.   JOURNAL OF PATHOLOGY

Epigenetic Down-Regulation and Suppressive Role of DCBLD2 in Gastric Cancer Cell Proliferation and Invasion

(2008) M. Kim et al.   MOLECULAR CANCER RESEARCH