Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating

(2015) Rosanna P. Baker et al.   NATURE

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clipping or Extracting: Two Ways to Membrane Protein Degradation

(2015) Dönem Avci et al.   TRENDS IN CELL BIOLOGY

Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

(2015) Wei Song et al.   Nature Communications

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1  in Breast Cancer

(2014) Z. Zhou et al.   CANCER RESEARCH

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance

(2014) Dönem Avci et al.   MOLECULAR CELL

From wavy hair to naked proteins: The role of transforming growth factor alpha in health and disease

(2014) Bhuminder Singh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3

(2013) Xiaoxia Ren et al.   FEBS LETTERS

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway

(2012) Jeremy C. Simpson et al.   NATURE CELL BIOLOGY

Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis

(2012) Chunhua Wan et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Amphiregulin Exosomes Increase Cancer Cell Invasion

(2011) James N. Higginbotham et al.   CURRENT BIOLOGY

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation

(2011) Justine P. Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Intramembrane Proteolysis in Regulated Protein Trafficking

(2011) Marius K. Lemberg   TRAFFIC

MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening

(2010) Hesso Farhan et al.   JOURNAL OF CELL BIOLOGY

EGF receptor activation by GPCRs: An universal pathway reveals different versions

(2010) Claus Liebmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

The role of protease activity in ErbB biology

(2008) Carl P. Blobel et al.   EXPERIMENTAL CELL RESEARCH

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

(2008) Huafei Zou et al.   FASEB JOURNAL

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

(2008) Juha Hakulinen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY