Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy

Defective Respiratory Tract Immune Surveillance in Asthma

(2014) Patrick G. Holt et al.   CHEST

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

(2014) David Martino et al.   Epigenetics

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells

(2014) Hiromasa Morikawa et al.   IMMUNOLOGICAL REVIEWS

GATA binding protein 3+ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates

(2014) Anna Forsberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dedicator of cytokinesis 8–deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

(2014) Erin Janssen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased food diversity in the first year of life is inversely associated with allergic diseases

(2014) Caroline Roduit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells

(2014) Jun Young Hong et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

(2014) Aleena Syed et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

(2014) Mario Noti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children

(2014) Supinda Bunyavanich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures

(2014) Matthew J. Gold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate lymphoid cells and asthma

(2014) Sanhong Yu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Food diversity in infancy and the risk of childhood asthma and allergies

(2014) Bright I. Nwaru et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD4+ T Cells from Human Neonates and Infants Are Poised Spontaneously To Run a Nonclassical IL-4 Program

(2014) K. Hebel et al.   JOURNAL OF IMMUNOLOGY

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes

(2014) D K Chu et al.   Mucosal Immunology

Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants

(2014) Deena Gibbons et al.   NATURE MEDICINE

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Gestational vitamin A deficiency reduces the intestinal immune response by decreasing the number of immune cells in rat offspring

(2014) Xia Liu et al.   NUTRITION

Maternal influences on fetal microbial colonization and immune development

(2014) Joann Romano-Keeler et al.   PEDIATRIC RESEARCH

Bacteria Localization and Chorion Thinning among Preterm Premature Rupture of Membranes

(2014) Kimberly B. Fortner et al.   PLoS One

Long-term effects of birth weight and breastfeeding duration on inflammation in early adulthood

(2014) T. W. McDade et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Placenta Harbors a Unique Microbiome

(2014) K. Aagaard et al.   Science Translational Medicine

Prenatal vitamin A deficiency impairs adaptive immune responses to pentavalent rotavirus vaccine (RotaTeq®) in a neonatal gnotobiotic pig model

(2014) Sukumar Kandasamy et al.   VACCINE

The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System

(2014) Lorella Paparo et al.   Nutrients

CD25+ regulatory T cells transfer n-3 long chain polyunsaturated fatty acids-induced tolerance in mice allergic to cow's milk protein

(2013) L. W. J. van den Elsen et al.   ALLERGY

Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis

(2013) Krista S Crider et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Antigen specific immunotherapy generates CD27+ CD35+ tolerogenic dendritic cells

(2013) Zhiqiang Wu   CELLULAR IMMUNOLOGY

Can vitamin D intake during pregnancy affect the risk of allergy in children?

(2013) Kristin M Junge et al.   Expert Review of Clinical Immunology

The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology

(2013) Mate Kiss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Atopic sensitization in the first year of life

(2013) Martin Depner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective T H 17 development in human neonatal T cells involves reduced RORC2 mRNA content

(2013) Sytze de Roock et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbial influence on tolerance and opportunities for intervention with prebiotics/probiotics and bacterial lysates

(2013) Petra Ina Pfefferle et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH17 differentiation capacity develops within the first 3 months of life

(2013) Krijn K. Dijkstra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vitamin D status at birth: An important and potentially modifiable determinant of atopic disease in childhood?

(2013) Leonard B. Bacharier   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of TH17 markers early in life through maternal farm exposure

(2013) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers

(2013) Gunda Herberth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a

(2013) A. C. Palin et al.   JOURNAL OF IMMUNOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Epigenetic programming and reprogramming during development

(2013) Irene Cantone et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inflammatory response and IgE sensitization at early age

(2013) Kirsi Mustonen et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

T cell subsets in cord blood are influenced by maternal allergy and associated with atopic dermatitis

(2013) Yujing Fu et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial

(2013) Stephen T. Goldring et al.   PLoS One

Prospective Study of Peripregnancy Consumption of Peanuts or Tree Nuts by Mothers and the Risk of Peanut or Tree Nut Allergy in Their Offspring

(2013) A. Lindsay Frazier et al.   JAMA Pediatrics

Prevalence of atopic disorders and immunodeficiency in patients with ectodermal dysplasia syndromes

(2012) Barry J. Mark et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The Biology of Recent Thymic Emigrants

(2012) Pamela J. Fink   Annual Review of Immunology

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

(2012) Omry Koren et al.   CELL

The role of the T follicular helper cells in allergic disease

(2012) DM Kemeny   Cellular & Molecular Immunology

Allergen-specific responses of CD19(+)CD5(+)Foxp3(+) regulatory B cells (Bregs) and CD4(+)Foxp3(+) regulatory T cell (Tregs) in immune tolerance of cow milk allergy of late eczematous reactions

(2012) Joonyong Noh et al.   CELLULAR IMMUNOLOGY

Fish oil supplementation in early infancy modulates developing infant immune responses

(2012) N. D'Vaz et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Timing of allergy-preventive and immunomodulatory dietary interventions - are prenatal, perinatal or postnatal strategies optimal?

(2012) M. C. Jenmalm et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Virus infection and allergy in the development of asthma

(2012) Patrick G. Holt et al.   Current Opinion in Allergy and Clinical Immunology

Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour

(2012) Suzanne J. Meldrum et al.   EARLY HUMAN DEVELOPMENT

Probiotics Supplementation During Pregnancy or Infancy for the Prevention of Atopic Dermatitis

(2012) Claudio Pelucchi et al.   EPIDEMIOLOGY

Peanut and tree nut consumption during pregnancy and allergic disease in children—should mothers decrease their intake? Longitudinal evidence from the Danish National Birth Cohort

(2012) Ekaterina Maslova et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prenatal and early-life exposures alter expression of innate immunity genes: The PASTURE cohort study

(2012) Georg Loss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

(2012) Joanne G. Lisciandro et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years

(2012) Diana Raedler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases

(2012) Susan L. Prescott   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-33 in the human placenta

(2012) Vanessa Topping et al.   Journal of Maternal-Fetal & Neonatal Medicine

Microbial contact during pregnancy, intestinal colonization and human disease

(2012) Samuli Rautava et al.   Nature Reviews Gastroenterology & Hepatology

Probiotics Modulate Host-Microbe Interaction in the Placenta and Fetal Gut: A Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Samuli Rautava et al.   Neonatology

Postnatal Fish Oil Supplementation in High-Risk Infants to Prevent Allergy: Randomized Controlled Trial

(2012) N. D'Vaz et al.   PEDIATRICS

Asthma Discordance in Twins Is Linked to Epigenetic Modifications of T Cells

(2012) R. Scott Runyon et al.   PLoS One

Early environments and the ecology of inflammation

(2012) T. W. McDade   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental biodiversity, human microbiota, and allergy are interrelated

(2012) I. Hanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunomodulatory Properties of Helicobacter pylori Confer Protection Against Allergic and Chronic Inflammatory Disorders

(2012) Isabelle C. Arnold et al.   Frontiers in Cellular and Infection Microbiology

The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood

(2011) J. A. Dunstan et al.   ALLERGY

Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year

(2011) D. Hinz et al.   ALLERGY

Evidence for a Causal Relationship between Allergic Sensitization and Rhinovirus Wheezing in Early Life

(2011) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort

(2011) R. M. McLoughlin et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The rs3761548 polymorphism of FOXP3 is a protective genetic factor against allergic rhinitis in the Hungarian female population

(2011) Eszter Fodor et al.   HUMAN IMMUNOLOGY

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Bacterial components plus vitamin D: The ultimate solution to the asthma (autoimmune disease) epidemic?

(2011) Scott T. Weiss   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reduced placental FOXP3 associated with subsequent infant allergic disease

(2011) Susan L. Prescott et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response

(2011) Pooja Varshney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Changes in thymic regulatory T-cell maturation from birth to puberty: Differences in atopic children

(2011) Meri K. Tulic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

(2011) Joanne G. Lisciandro et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Maternal obesity associated with inflammation in their children

(2011) Karen L. Leibowitz et al.   World Journal of Pediatrics

Maternal consumption of high-prebiotic fibre or -protein diets during pregnancy and lactation differentially influences satiety hormones and expression of genes involved in glucose and lipid metabolism in offspring in rats

(2010) Alannah D. Maurer et al.   BRITISH JOURNAL OF NUTRITION

Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function

(2010) Pia Reece et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny

(2010) Meri K. Tulic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta-analysis

(2010) Ulugbek Nurmatov et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

FOXP3, IL-10, and TGF-β Genes Expression in Children with IgE-Dependent Food Allergy

(2010) Aneta Krogulska et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Counterregulation between the Fc RI Pathway and Antiviral Responses in Human Plasmacytoid Dendritic Cells

(2010) M. A. Gill et al.   JOURNAL OF IMMUNOLOGY

Diet, gut microbiota and immune responses

(2010) Kendle M Maslowski et al.   NATURE IMMUNOLOGY

Maternal Vitamin A Supplementation and Lung Function in Offspring

(2010) William Checkley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thymic stromal lymphopoietin is present in human breast milk

(2010) Trisha V. Macfarlane et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts

(2009) R. W. B. Bottema et al.   ALLERGY

Microbial exposure, interferon gamma gene demethylation in naïve T-cells, and the risk of allergic disease

(2009) P. J. Vuillermin et al.   ALLERGY

Effect of Supplemental Folic Acid in Pregnancy on Childhood Asthma: A Prospective Birth Cohort Study

(2009) M. J. Whitrow et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC/Nga mice

(2009) Reiko Fujiwara et al.   BRITISH JOURNAL OF NUTRITION

Genetic and environmental contributions to allergen sensitization in a Chinese twin study

(2009) X. Liu et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Genetic association study of FOXP3 polymorphisms in allergic rhinitis in a Chinese population

(2009) Luo Zhang et al.   HUMAN IMMUNOLOGY

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells

(2009) Bianca Schaub et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the National Health and Nutrition Examination Survey 2005-2006

(2009) Cynthia M. Visness et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein

(2009) Wayne G. Shreffler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy–treated mother

(2009) Sabine Flicker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

(2009) Karin R. Engelhardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Maternal obesity in pregnancy and respiratory health in early childhood

(2009) Siri E. Håberg et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Serum leptin and adiponectin levels and their association with allergic sensitization

(2008) K. Radon et al.   ALLERGY

Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection

(2008) S. L. Prescott et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Children with egg allergy have evidence of reduced neonatal CD4+CD25+CD127lo/− regulatory T cell function

(2008) Miranda Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BifidobacteriumandLactobacillusDNA in the human placenta

(2008) R. Satokari et al.   LETTERS IN APPLIED MICROBIOLOGY