Article
Biochemistry & Molecular Biology
Junghoon Kim, Kyeng-Won Choi, Jungwoon Lee, Jaeyoung Lee, Seonock Lee, Ruijing Sun, Jungho Kim
Summary: The CD44(+)CD133(+) subpopulation from Caco-2 cells is highly enriched in tumorigenic cells with unusual proliferative capacity and tumor-forming potential. These cells exhibit faster tumor growth in secondary xenografts, and the over-activation of the Wnt/beta-catenin pathway is closely associated with their nature.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Viktorija Juric, Heiko Dussmann, Martine L. M. Lamfers, Jochen H. M. Prehn, Markus Rehm, Brona M. Murphy
Summary: This study highlights the potential of using transcriptional CDK inhibitors to prevent tumor recurrence, particularly in aggressive adult brain tumor GBM. The expression of GSC markers CD133 and CD44 is significantly upregulated in GBM patient tumors, and GSCs are more sensitive to transcriptional CDK inhibitors.
Review
Immunology
Ya-Jui Lin, Caren Yu-Ju Wu, Janet Yuling Wu, Michael Lim
Summary: Glioblastoma is a highly aggressive glioma with resistance to immunotherapy, primarily due to the unique immune environment. Myeloid cells play a significant role in the glioma microenvironment and reprogramming them has emerged as a revolutionary immunotherapy for glioma treatment. This article provides a detailed classification and analysis of myeloid cells in glioma TME, aiming to offer new insights and therapeutic approaches for improving treatment efficacy in glioma patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yingying Liu, Peisheng Chen, Liufei Xu, Bo Wang, Shengping Zhang, Xiangpeng Wang
Summary: In this study, researchers found that the expression level of GALNT2 is elevated in GBM, IDH1 wildtype glioma, and GSCs. GALNT2 expression is correlated with unfavorable clinical outcomes in GBM patients. Targeting GALNT2 can block GSCs cell proliferation, self-renewal, and malignant invasion through repressing CD44 expression.
Article
Polymer Science
Rakshita Grover, Sahil Drall, Neelam Poonia, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather, Prashant Kesharwani, Deepti Pandita, Ramesh K. Goyal
Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Oncology
Chia-Hung Chien, Chien-Cheng Lai, Jian-Ying Chuang, Jui-Mei Chu, Chan-Chuan Liu, Kwang-Yu Chang
Summary: SH3GLB1 plays a crucial role in the resistance of glioblastoma cells to temozolomide through autophagy-mediated oxidative phosphorylation related to CD133 levels, and it may regulate CD133 expression to impact tumor-initiating cells (TICs).
Article
Oncology
Sho Tamai, Toshiya Ichinose, Shabierjiang Jiapaer, Nozomi Hirai, Hemragul Sabit, Shingo Tanaka, Masashi Kinoshita, Masahiko Kobayashi, Atsushi Hirao, Mitsutoshi Nakada
Summary: In this study, pentamidine was identified as a potential therapeutic drug for glioma by drug reposition. Pentamidine inhibited proliferation and stemness of glioma-initiating cells, and showed anticancer effects on differentiated glioma-initiating cells and glioblastoma cell lines. The in vivo study confirmed the anticancer effects of pentamidine on glioma cells.
Article
Environmental Sciences
Yunhe Lu, Wei Wang, Shubin Tan
Summary: This study identified that EHD1 was upregulated in glioma cells and played a role in promoting cancer stem cell-like traits through enhancing CD44 stability and preventing ubiquitination. The study also revealed a higher expression of EHD1 in glioma tissues, which correlated with the expression of CSC markers and patient survival.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Cong He, Luoyan Sheng, Deshen Pan, Shuai Jiang, Li Ding, Xiaojun Ma, Yaohua Liu, Deshui Jia
Summary: High-grade glioma, characterized by extensive tumor heterogeneity, was analyzed through single-cell RNA sequencing to identify cellular and molecular mechanisms driving tumor heterogeneity. The study revealed a dominance of tumor-associated macrophages in the immune microenvironment, along with five distinct subpopulations of tumor cells and highlighted the critical role of the SPP1/CD44 axis in glioma progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Daisuke Yamashita, Joshua D. Bernstock, Galal Elsayed, Hirokazu Sadahiro, Ahmed Mohyeldin, Gustavo Chagoya, Adeel Ilyas, James Mooney, Dagoberto Estevez-Ordonez, Shinobu Yamaguchi, Victoria L. Flanary, James R. Hackney, Krishna P. Bhat, Harley I. Kornblum, Nicola Zamboni, Sung-Hak Kim, E. Antonio Chiocca, Ichiro Nakano
Summary: Despite aggressive multimodal therapy, glioblastoma (GBM) still has a poor prognosis due to tumor heterogeneity at the molecular and cellular levels. This study aimed to identify metabolic differences between GBM tumor core cells and edge cells, potentially revealing new therapeutic targets related to tumor metabolism. Comprehensive metabolic analyses on high-grade glioma tissues and glioma-initiating cell culture models showed metabolic heterogeneity, with implications for targeting tyrosine metabolism in GBM, especially in the tumor core region. Activation of the enzyme tyrosine aminotransferase (TAT) within this pathway influenced therapeutic resistance in the GBM core, suggesting selective inhibition of tyrosine metabolism as a promising adjuvant therapy for GBM.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Tengjiao Ma, Chengchen Hu, Bachchu Lal, Weiqiang Zhou, Yongxin Ma, Mingyao Ying, Panagiotis Prinos, Alfredo Quinones-Hinojosa, Michael Lim, John Laterra, Yunqing Li
Summary: This study reveals that Oct4 and Sox2 coexpression contributes to the immunosuppressive phenotype of glioblastoma stem-like cells (GSCs) through the induction of an immunosuppressive transcriptome and the dysregulation of cytokines and chemokines associated with an immunosuppressive tumor microenvironment. Targeting mechanisms involving BRD/H3K27Ac-dependent immunosuppressive genes could provide new avenues for therapy in GSCs.
Article
Biochemistry & Molecular Biology
Corinna Seliger, Lisa Rauer, Anne-Louise Wuester, Sylvia Moeckel, Verena Leidgens, Birgit Jachnik, Laura-Marie Ammer, Simon Heckscher, Katja Dettmer, Markus J. Riemenschneider, Peter J. Oefner, Martin Proescholdt, Arabel Vollmann-Zwerenz, Peter Hau
Summary: Metformin has inhibitory effects on brain tumor-initiating cells (BTICs), but its effectiveness in vivo remains unclear. It was found that BTICs of different molecular subtypes have distinct amino acid profiles, and metformin treatment can inhibit their growth in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Melis Savasan Sogut, Chitra Venugopal, Basak Kandemir, Ugur Dag, Sujeivan Mahendram, Sheila Singh, Gizem Gulfidan, Kazim Yalcin Arga, Bayram Yilmaz, Isil Aksan Kurnaz
Summary: Elk-1, a member of the ETS domain superfamily, is a transcription factor involved in neuroprotection, neurodegeneration, and brain tumor proliferation. It regulates known targets like c-fos and egr-1, as well as SMN, SOD1, PSEN1, and CD133. Microarray analysis revealed Elk-1's significant regulation of genes related to nervous system development, pluripotency, and apoptosis. Elk-1 also plays a role in the self-renewal of CD133+ BTICs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yuanyan Wei, Shuting Geng, Yu Si, Yuerong Yang, Qihang Chen, Sijing Huang, Xiaoning Chen, Wenlong Xu, Yinchao Liu, Jianhai Jiang
Summary: The study identifies COL1 as an extracellular binding molecule of cancer stem cells marker CD133. The interaction between COL1 and CD133 enhances the tumorigenesis of GSCs by up-regulating SLC1A5-dependent glutamine uptake. This finding provides a new mechanism underlying the cross-talk between GSCs and ECM microenvironment.
Article
Oncology
Ziwei Liang, Bingrui Wu, Zhi Ji, Weitao Liu, Danfang Shi, Xiaoning Chen, Yuanyan Wei, Jianhai Jiang
Summary: LDN193189 inhibits liver TIC self-renewal, tumorigenicity, and immune escape by targeting CD133 phosphorylation, providing a potential therapeutic approach to targeting the CD133-Galectin-3 axis for liver cancer treatment.
Article
Clinical Neurology
Masahiro Oishi, Yasuhiko Hayashi, Yasuo Sasagawa, Nozomu Oikawa, Mitsutoshi Nakada
Summary: Although rare, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) may present as an initial sign of hypothalamic PCNSL.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Toshiya Ichinose, Masashi Kinoshita, Riho Nakajima, Shingo Tanaka, Mitsutoshi Nakada
Summary: Brain mapping during awake craniotomy for gliomas is an effective technique to preserve neurological functions, including vision. However, the consecutive changes in the visual field need further investigation.
Article
Clinical Neurology
Kazuya Futami, Kouichi Misaki, Takehiro Uno, Iku Nambu, Taishi Tsutsui, Tomoya Kamide, Mitsutoshi Nakada
Summary: This study investigated the relationship between the locations of minimum wall shear stress (Min-WSS) points and their underlying intra-aneurysmal flow structure patterns in unruptured cerebral aneurysms using four-dimensional flow magnetic resonance imaging (MRI). The majority of Min-WSS points were found to be located around a vortex core or center, and different locations had different Min-WSS values. Further research can help identify cerebral aneurysms with a higher risk of wall instability.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Keijiro Shomura, Tomoya Kamide, Kouichi Misaki, Taishi Tsutsui, Iku Nambu, Naoyuki Uchiyama, Mitsutoshi Nakada
Summary: Cerebral proliferative angiopathy (CPA) is a rare vascular abnormality that is distinct from classical brain arteriovenous malformations. This article describes a case of cerebral hemorrhage caused by CPA and successful treatment using two different endovascular techniques.
CASE REPORTS IN NEUROLOGY
(2022)
Article
Oncology
Tomonobu Koizumi, Yoshikazu Nishino, Tomoya Takiguchi, Shintaro Kanda, Kengo Otsuki, Yuriko Tanaka, Reiji Tomita, Taisuke Araki, Ryuji Hayashi, Kazuo Yasumoto, Hidetaka Uramoto, Yasuo Hirono, Tomoe Makino, Mitsutoshi Nakada, Seiji Yano
Summary: This study analyzed the treatment patterns of lung cancer patients over and under 80 years old and found differences in their choices. It aimed to validate the epidemiology, initial treatment, and clinical practice in lung cancer patients in the Hokushin region of Japan. The results showed that patients over 80 years old were more likely to choose best supportive care and biomarker-based therapy.
CLINICAL LUNG CANCER
(2023)
Article
Oncology
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, Tomokazu Yoshizaki, Toyoyuki Hanazawa, Kiyoshi Misawa, Atsushi Kaneda
Summary: Human papillomavirus (HPV) plays a causal role in the development of head and neck squamous cell carcinoma (HNSCC) by integrating into the host genome and causing genomic alterations. This study analyzed the epigenome, transcriptome, and interactome of HPV-positive HNSCCs to understand the role of epigenetic dysregulation in tumorigenesis. The results showed that genes neighboring HPV integration sites were upregulated and correlated with oncogenic phenotypes in HPV-positive HNSCCs. The epigenetic activation of HPV-interacting regions (HPVIRs) contributed to the genesis of HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miu Mizuhata, Shigeyuki Takamatsu, Satoshi Shibata, Takayuki Sakurai, Risako Minamikawa, Masahiro Yamazaki, Masashi Kinoshita, Katsuyoshi Miyashita, Tomoyasu Kumano, Mitsutoshi Nakada, Toshifumi Gabata
Summary: The purpose of this study was to analyze the failure patterns in patients with glioblastoma multiforme treated using chemoradiotherapy. The study found that the standard course had a longer median survival time compared to the short course in all cases, but the recurrence pattern of the short course was similar to that of the standard treatment.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kota Ebina, Mie Matsui, Masashi Kinoshita, Daisuke Saito, Mitsutoshi Nakada
Summary: This study investigated whether a higher premorbid IQ has a beneficial impact on postoperative verbal short-term memory and functional outcomes in patients with brain tumors. The results showed that low white matter tract damage and low premorbid IQ both had negative effects on postoperative functional outcomes. However, when the brain lesions were not located in a crucial pathway, a higher premorbid IQ was associated with better postoperative verbal short-term memory and functional outcomes.
Article
Multidisciplinary Sciences
Kouichi Misaki, Tomoya Kamide, Takehiro Uno, Taishi Tsutsui, Iku Nambu, Mitsutoshi Nakada
Summary: This study established a scoring system and analyzed the characteristics of 177 cerebral angiography cases. The results showed significant differences in scores, suggesting that the scoring system can serve as an indicator of proficiency in cerebral angiography.
Review
Oncology
Sho Tamai, Toshiya Ichinose, Mitsutoshi Nakada
Summary: An ideal biomarker for glioma must meet certain parameters, but the nature of the disease makes it challenging. Liquid biomarkers for brain disease offer advantages over traditional histological examination. However, the heterogeneous nature of glioma and the low incidence of brain tumors hinder progress in discovering useful biomarkers. New advancements in specimen types and comprehensive omics analysis have identified some candidate liquid biomarkers. Further research and multicenter studies are needed to establish new treatment strategies.
BRAIN TUMOR PATHOLOGY
(2023)
Article
Oncology
Sho Tamai, Toshiya Ichinose, Shabierjiang Jiapaer, Nozomi Hirai, Hemragul Sabit, Shingo Tanaka, Masashi Kinoshita, Masahiko Kobayashi, Atsushi Hirao, Mitsutoshi Nakada
Summary: In this study, pentamidine was identified as a potential therapeutic drug for glioma by drug reposition. Pentamidine inhibited proliferation and stemness of glioma-initiating cells, and showed anticancer effects on differentiated glioma-initiating cells and glioblastoma cell lines. The in vivo study confirmed the anticancer effects of pentamidine on glioma cells.
Article
Neurosciences
Takehiro Uno, Kouichi Misaki, Riho Nakajima, Iku Nambu, Akifumi Yoshikawa, Tomoya Kamide, Mitsutoshi Nakada
Summary: This study investigated the level of bifurcation in the common femoral artery (CFA) in 100 patients and found that approximately one-fourth of the patients had a high level of CFA bifurcation, which was associated with old age and a history of diabetes. For patients in need of urgent treatment, femoral artery puncture can be performed at a higher level below the inguinal ligament if they are elderly or have a history of diabetes.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Munehiro Demura, Hiroshi Ishii, Mika Takarada-Iemata, Tomoya Kamide, Akifumi Yoshikawa, Mitsutoshi Nakada, Osamu Hori
Summary: This study investigated the role of cerebral circulation in the acute phase following SAH using patient data and a mouse SAH model, and evaluated its regulation via the sympathetic nervous system. The results showed that cerebral circulation time was prolonged in the acute phase of SAH, especially in patients with electrocardiographic changes. In the mouse study, sympathetic hyperactivity was found to impair cerebral microcirculation and contribute to brain edema development in the acute phase following SAH.
Article
Clinical Neurology
Yasuo Sasagawa, Mitsutaka Nakahara, Daisuke Takemoto, Mitsutoshi Nakada
Summary: Optical coherence tomography (OCT) is a useful tool for predicting visual recovery after pituitary tumor removal, but its utility in patients with normal visual fields is unclear. This study analyzed OCT features in pituitary tumors without visual field defects and found that macular thickness ganglion cell complex (mGCC) was significantly thinner in patients with chiasmal compression (CC) compared to those without. Abnormal mGCC thickness was more common in the CC group and associated with older age. OCT can detect early optic nerve damage in patients with pituitary tumors, even in the absence of visual field defects.
NEUROSURGICAL REVIEW
(2023)
Article
Oncology
Eri Okura, Yoshikazu Nishino, Kazuo Sakashita, Azusa Tanimoto, Ryuji Hayashi, Yoshio Yoshida, Mitsutoshi Nakada, Tomonobu Koizumi, Seiji Yano, Yozo Nakazawa
Summary: The study analyzed cancer data of children, adolescents, and young adults in four adjacent prefectures of Japan, revealing differences in cancer incidence rates among different age groups. Carcinomas were found to be the most common type of cancer in the 15-39 age group but not in the pediatric population. Further research is needed to understand the unique needs of adolescents and young adults with cancer.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)