Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein-Protein Antagonists

HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery

(2013) Bainan Wu et al.   CHEMISTRY & BIOLOGY

Amino Acid Conjugates of Lithocholic Acid As Antagonists of the EphA2 Receptor

(2013) Matteo Incerti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4

(2012) Srinivas Duggineni et al.   BIOCHEMICAL PHARMACOLOGY

Structure-Activity Relationships and Mechanism of Action of Eph-ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor

(2012) Massimiliano Tognolini et al.   ChemMedChem

Patented TGR5 modulators: a review (2006 – present)

(2012) Antimo Gioiello et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Perturbation of the EphA2–EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites

(2012) Massimiliano Tognolini et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

(2012) Geoffrey Porez et al.   JOURNAL OF LIPID RESEARCH

Novel Targeted System To Deliver Chemotherapeutic Drugs to EphA2-Expressing Cancer Cells

(2012) Si Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

(2012) Aaron Petty et al.   PLoS One

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2

(2012) S. M. Vogel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling Eph receptor expression in cells and tissues

(2012) Roberta Noberini et al.   Cell Adhesion & Migration

Synthesis and proteasome inhibition of lithocholic acid derivatives

(2011) Zhao Dang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Disalicylic Acid-Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors

(2011) Roberta Noberini et al.   Chemical Biology & Drug Design

Rapid Shape-Based Ligand Alignment and Virtual Screening Method Based on Atom/Feature-Pair Similarities and Volume Overlap Scoring

(2011) G. Madhavi Sastry et al.   Journal of Chemical Information and Modeling

Polyphenol rich botanicals used as food supplements interfere with EphA2–ephrinA1 system

(2011) Iftiin Hassan Mohamed et al.   PHARMACOLOGICAL RESEARCH

Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation

(2011) Carmine Giorgio et al.   PLoS One

Ectodomain structures of Eph receptors

(2011) Juha P. Himanen   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting Eph receptors with peptides and small molecules: Progress and challenges

(2011) Roberta Noberini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

(2009) Juha P Himanen et al.   EMBO REPORTS

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY