Arrestins: structural disorder creates rich functionality

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

(2017) Yuri K. Peterson et al.   PHARMACOLOGICAL REVIEWS

Structural basis of arrestin-3 activation and signaling

(2017) Qiuyan Chen et al.   Nature Communications

C-edge loops of arrestin function as a membrane anchor

(2017) Ciara C M. Lally et al.   Nature Communications

Understanding the Differential Selectivity of Arrestins toward the Phosphorylation State of the Receptor

(2016) Ozge Sensoy et al.   ACS Chemical Neuroscience

Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins

(2016) Vladimir N. Uversky   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(2016) Susanne Nuber et al.   NATURE

Peptide mini-scaffold facilitates JNK3 activation in cells

(2016) Xuanzhi Zhan et al.   Scientific Reports

Different conformational dynamics of β-arrestin1 and β-arrestin2 analyzed by hydrogen/deuterium exchange mass spectrometry

(2015) Youngjoo Yun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Functional roles of transiently and intrinsically disordered regions within proteins

(2015) Vladimir N. Uversky   FEBS Journal

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

Structural evidence for the role of polar core residue Arg175 in arrestin activation

(2015) Joachim Granzin et al.   Scientific Reports

Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains

(2014) Xuanzhi Zhan et al.   CELLULAR SIGNALLING

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

(2014) Vladimir N. Uversky et al.   CHEMICAL REVIEWS

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

 -arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism

(2014) E. Fernandez-Arenas et al.   EMBO JOURNAL

Arrestin makes T cells stop and become active

(2014) V. V. Gurevich et al.   EMBO JOURNAL

Identification of Receptor Binding-induced Conformational Changes in Non-visual Arrestins

(2014) Ya Zhuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional map of arrestin-1 at single amino acid resolution

(2014) Martin K. Ostermaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural and functional signatures of proteins that undergo multiple events of post-translational modification

(2014) Vikas Pejaver et al.   PROTEIN SCIENCE

Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death

(2013) S Kook et al.   CELL DEATH AND DIFFERENTIATION

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

(2013) Marija Buljan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Critical Role of the Central 139-Loop in Stability and Binding Selectivity of Arrestin-1

(2013) Sergey A. Vishnivetskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK3 Enzyme Binding to Arrestin-3 Differentially Affects the Recruitment of Upstream Mitogen-activated Protein (MAP) Kinase Kinases

(2013) Xuanzhi Zhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin-3 Binds c-Jun N-terminal Kinase 1 (JNK1) and JNK2 and Facilitates the Activation of These Ubiquitous JNK Isoforms in Cells via Scaffolding

(2013) Seunghyi Kook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of pre-activated arrestin p44

(2013) Yong Ju Kim et al.   NATURE

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin

(2013) T. Zhuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina

(2013) Hormoz Moaven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unusual biophysics of intrinsically disordered proteins

(2012) Vladimir N. Uversky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

(2012) Fatemeh Miri Disfani et al.   BIOINFORMATICS

Silent Scaffolds

(2012) Maya Breitman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of p44, a Constitutively Active Splice Variant of Visual Arrestin

(2012) Joachim Granzin et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformation of receptor-bound visual arrestin

(2012) M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Ubiquitin Ligase Parkin Promotes Mdm2–Arrestin Interaction but Inhibits Arrestin Ubiquitination

(2011) M. Rafiuddin Ahmed et al.   BIOCHEMISTRY

A Single Mutation in Arrestin-2 Prevents ERK1/2 Activation by Reducing c-Raf1 Binding

(2011) Sergio Coffa et al.   BIOCHEMISTRY

Few Residues within an Extensive Binding Interface Drive Receptor Interaction and Determine the Specificity of Arrestin Proteins

(2011) Sergey A. Vishnivetskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

(2011) Xuanzhi Zhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation

(2011) Sergio Coffa et al.   PLoS One

The functional cycle of visual arrestins in photoreceptor cells

(2011) Vsevolod V. Gurevich et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Elucidation of Inositol Hexaphosphate and Heparin Interaction Sites and Conformational Changes in Arrestin-1 by Solution Nuclear Magnetic Resonance

(2010) Tiandi Zhuang et al.   BIOCHEMISTRY

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Arrestin-1 expression level in rods: balancing functional performance and photoreceptor health

(2010) X. Song et al.   NEUROSCIENCE

ANCHOR: web server for predicting protein binding regions in disordered proteins

(2009) Z. Dosztanyi et al.   BIOINFORMATICS

Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin Phosphorylation

(2009) Xiufeng Song et al.   CURRENT BIOLOGY

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

(2009) Dong Soo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Arrestin α-Helix I in Receptor Binding

(2009) Sergey A. Vishnivetskiy et al.   JOURNAL OF MOLECULAR BIOLOGY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

How Does Arrestin Assemble MAPKs into a Signaling Complex?

(2008) Xiufeng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE