Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression

(2018) Mahmod Panahi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

(2018) Zeming Wu et al.   Protein & Cell

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

(2018) Ping Wang et al.   Protein & Cell

Redistribution of Mature Smooth Muscle Markers in Brain Arteries in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

(2018) John R. Gatti et al.   Translational Stroke Research

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

(2018) Si Wang et al.   Cell Discovery

Epigenetic Modifications in Cardiovascular Aging and Diseases

(2018) Weiqi Zhang et al.   CIRCULATION RESEARCH

Chemical screen identifies a geroprotective role of quercetin in premature aging

(2018) Lingling Geng et al.   Protein & Cell

The function and mechanism of preactivated thiomers in triggering epithelial tight junctions opening

(2018) Yang Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton

(2018) Sandra Fuertes-Alvarez et al.   Cell Death & Disease

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

(2018) Hai-Qing Tu et al.   Nature Communications

Vasoreactivity in CADASIL: Comparison to structural MRI and neuropsychology

(2017) Fiona C Moreton et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

(2017) Lixia Wang et al.   Protein & Cell

STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer

(2017) Rui Li et al.   Scientific Reports

Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice

(2016) Carmen Capone et al.   ANNALS OF NEUROLOGY

Effect of notch1,2,3 genes silicing on NF-κB signaling pathway of macrophages in patients with atherosclerosis

(2016) Zhong-bao Ruan et al.   BIOMEDICINE & PHARMACOTHERAPY

Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping:in vitroproof of concept

(2016) Julie W. Rutten et al.   BRAIN

Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral ArteriesNovelty and Significance

(2016) Celine Baron-Menguy et al.   HYPERTENSION

Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway

(2016) Jiunn-Ren Wu et al.   International Journal of Biological Sciences

NIBP impacts on the expression of E-cadherin, CD44 and vimentin in colon cancer via the NF-κB pathway

(2016) CHUN-YAN XU et al.   Molecular Medicine Reports

Looking to the future following 10 years of induced pluripotent stem cell technologies

(2016) Mo Li et al.   Nature Protocols

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Soluble N-cadherin: A novel inhibitor of VSMC proliferation and intimal thickening

(2016) Cressida A. Lyon et al.   VASCULAR PHARMACOLOGY

Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin

(2016) Claudia Fogl et al.   Nature Communications

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

(2016) Lina Fu et al.   Protein & Cell

Vascular smooth muscle cell in atherosclerosis

(2015) D. A. Chistiakov et al.   Acta Physiologica

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

A biomechanical perspective on stress fiber structure and function

(2015) Elena Kassianidou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

(2015) Christoph Patsch et al.   NATURE CELL BIOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Immunolocalization of platelet-derived growth factor receptor-β (PDGFR-β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

(2015) Lucinda J.L. Craggs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Atherosclerosis – A matter of unresolved inflammation

(2015) Joana Viola et al.   SEMINARS IN IMMUNOLOGY

Temporal and Embryonic Lineage-Dependent Regulation of Human Vascular SMC Development by NOTCH3

(2015) Alessandra Granata et al.   STEM CELLS AND DEVELOPMENT

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3

(2015) Xiaojie Zhang et al.   Translational Stroke Research

Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway

(2015) Yang Song et al.   FEBS Open Bio

VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning: Table 1

(2014) Yi Jin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells

(2014) Lei Ye et al.   Cell Stem Cell

Interpretation ofNOTCH3mutations in the diagnosis of CADASIL

(2014) Julie W Rutten et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

(2014) Guang-Hui Liu et al.   Nature Communications

Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension

(2014) Quynh N. Dinh et al.   Biomed Research International

NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome

(2014) Hyun Mu Shin et al.   Frontiers in Immunology

Non-Canonical Notch Signaling in Cancer and Immunity

(2014) Furkan Ayaz et al.   Frontiers in Oncology

Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL

(2013) Marie Monet-Leprêtre et al.   BRAIN

Diabetes Mellitus and Inflammation

(2013) Eric Lontchi-Yimagou et al.   Current Diabetes Reports

NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities

(2013) Matthew J. Killeen et al.   DRUG DISCOVERY TODAY

The role of thrombospondin-1 in cardiovascular health and pathology

(2013) Smriti Murali Krishna et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The role of vascular remodeling and inflammation in the pathogenesis of intracranial aneurysms

(2013) David L. Penn et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2012) Hairong Dong et al.   BRAIN RESEARCH

Experimental studies of mitochondrial function in CADASIL vascular smooth muscle cells

(2012) Matti Viitanen et al.   EXPERIMENTAL CELL RESEARCH

Prognostic value of serum PIIINP, MMP1 and TIMP1 levels in hypertensive patients: a community-based prospective cohort study

(2012) Nelly Agrinier et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

CADASIL Mutations and shRNA Silencing of NOTCH3 Affect Actin Organization in Cultured Vascular Smooth Muscle Cells

(2012) Saara Tikka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deciphering actin cytoskeletal function in the contractile vascular smooth muscle cell

(2012) Rina Yamin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Biochemical Characterization and Cellular Effects of CADASIL Mutants of NOTCH3

(2012) He Meng et al.   PLoS One

Notch signaling in human development and disease

(2012) Andrea L. Penton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Non-canonical Notch signaling: emerging role and mechanism

(2012) Peter Andersen et al.   TRENDS IN CELL BIOLOGY

Ultrastructural Changes in Cerebral Capillary Pericytes in Aged Notch3 Mutant Transgenic Mice

(2012) Xin Gu et al.   ULTRASTRUCTURAL PATHOLOGY

RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction

(2011) Deepak Venkatesh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs

(2011) Mo Li et al.   CELL RESEARCH

Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs

(2011) Guang-Hui Liu et al.   Cell Stem Cell

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis

(2011) Marco Duering et al.   HUMAN MOLECULAR GENETICS

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Intracranial aneurysms: from vessel wall pathology to therapeutic approach

(2011) Timo Krings et al.   Nature Reviews Neurology

Pathogenesis of CADASIL

(2010) Anne Joutel   BIOESSAYS

Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

(2010) Hua Liu et al.   CIRCULATION RESEARCH

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

CADASIL

(2010) D. Hervé et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

NOTCH3 mutations and clinical features in 33 mainland Chinese families with CADASIL

(2010) Z. Wang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients

(2009) Saara Tikka et al.   BRAIN

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Arterial–Venous Specification During Development

(2009) Matthew R. Swift et al.   CIRCULATION RESEARCH

ADAM19/Adamalysin 19 Structure, Function, and Role as a Putative Target in Tumors and Inflammatory Diseases

(2009) Bin Qi et al.   CURRENT PHARMACEUTICAL DESIGN

Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation

(2009) Keikichi Takahashi et al.   HUMAN MOLECULAR GENETICS

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Thrombospondins: from structure to therapeutics

(2008) A. Bonnefoy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comparative Analysis of the Expression Patterns of Various TNFSF/TNFRSF in Atherosclerotic Plaques

(2008) Won-Jung Kim et al.   IMMUNOLOGICAL INVESTIGATIONS

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE