iRhom1 regulates proteasome activity via PAC1/2 under ER stress

Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1  in Breast Cancer

(2014) Z. Zhou et al.   CANCER RESEARCH

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

(2013) Jonghee Han et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA damage emergency: cellular garbage disposal to the rescue?

(2013) H R Stone et al.   ONCOGENE

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

(2012) Sang Mi Shim et al.   Cell Reports

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

(2011) Utano Tomaru et al.   AMERICAN JOURNAL OF PATHOLOGY

The Cdc48 machine in endoplasmic reticulum associated protein degradation

(2011) Dieter H. Wolf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

TCF11 at the crossroads of oxidative stress and the ubiquitin proteasome system

(2011) Annett Koch et al.   CELL CYCLE

Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntingtons Disease

(2011) R. Vidal et al.   CURRENT MOLECULAR MEDICINE

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

(2011) Huikyong Lee et al.   HUMAN MOLECULAR GENETICS

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity

(2010) SangMi Shim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibiting the ubiquitin–proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

(2010) Xiang Li et al.   HUMAN MOLECULAR GENETICS

Osmotic Stress Inhibits Proteasome by p38 MAPK-dependent Phosphorylation

(2010) Seung-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modularity of the Hrd1 ERAD complex underlies its diverse client range

(2010) Kazue Kanehara et al.   JOURNAL OF CELL BIOLOGY

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

(2010) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

Lectin-like ERAD players in ER and cytosol

(2009) Yukiko Yoshida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition

(2009) Jee-Yeon Noh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

(2009) Precious J. Lim et al.   JOURNAL OF CELL BIOLOGY

Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain

(2009) Elizabeth Crowe et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hsm3/S5b Joins the Ranks of 26S Proteasome Assembly Chaperones

(2009) Daniela Gödderz et al.   MOLECULAR CELL

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

(2008) Zhenwen Yan et al.   MOLECULAR CANCER THERAPEUTICS

Rhomboids: 7 years of a new protease family

(2008) Matthew Freeman   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY