标题
The molecular, cellular and pathophysiological roles of iRhom pseudoproteases
作者
关键词
-
出版物
Open Biology
Volume 9, Issue 3, Pages 190003
出版商
The Royal Society
发表日期
2019-03-20
DOI
10.1098/rsob.190003
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNFα pathway
- (2018) Coline Haxaire et al. BLOOD
- Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease
- (2018) Kathryn Prame Kumar et al. CELL AND TISSUE RESEARCH
- Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation
- (2018) Yiran Zhang et al. CELLULAR SIGNALLING
- Tylosis associated with squamous cell carcinoma of the oesophagus (TOC): Report of an African family with a novel RHBDF2 variant
- (2018) T. Mokoena et al. CLINICAL GENETICS
- RHBDF1 regulates APC-mediated stimulation of the epithelial-to-mesenchymal transition and proliferation of colorectal cancer cells in part via the Wnt/β-catenin signalling pathway
- (2018) Huiping Yuan et al. EXPERIMENTAL CELL RESEARCH
- iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling
- (2018) Xiaoping Qing et al. JOURNAL OF CLINICAL INVESTIGATION
- Neutrophil and macrophage cell surface CSF-1 shed by ADAM17 drives mouse macrophage proliferation in acute and chronic inflammation
- (2018) Jingjing Tang et al. MOLECULAR AND CELLULAR BIOLOGY
- p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
- (2018) Paola Arcidiacono et al. Nature Communications
- Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury
- (2018) Jee Hyun Kim et al. Scientific Reports
- FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
- (2018) Ulrike Künzel et al. eLife
- iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
- (2018) Ioanna Oikonomidi et al. eLife
- The discovery of proteases and intramembrane proteolysis
- (2018) Sandra Paschkowsky et al. Biochemistry and Cell Biology
- The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
- (2018) Anežka Tichá et al. TRENDS IN BIOCHEMICAL SCIENCES
- Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing
- (2017) Vishnu Hosur et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells
- (2017) Takatsugu Ishimoto et al. GASTROENTEROLOGY
- Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis
- (2017) Xue Li et al. JOURNAL OF CELL SCIENCE
- Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
- (2017) Thiviyani Maruthappu et al. Nature Communications
- Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
- (2017) Miguel Cavadas et al. Cell Reports
- iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA
- (2017) Wei-Wei Luo et al. PLoS Pathogens
- Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
- (2017) Adam Graham Grieve et al. eLife
- Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis
- (2017) Vishnu Hosur et al. Biology Open
- Pathophysiology of Hemophilic Arthropathy
- (2017) Daniela Melchiorre et al. Journal of Clinical Medicine
- iRhom2 Uncv mutation blocks bulge stem cells assuming the fate of hair follicle
- (2016) Leilei Yang et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
- (2016) Philippe Gascard et al. GENES & DEVELOPMENT
- iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
- (2016) Wei-Wei Luo et al. NATURE IMMUNOLOGY
- Inactive rhomboid proteins: New mechanisms with implications in health and disease
- (2016) Marius K. Lemberg et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Proteomic analysis of differentially expressed skin proteins in iRhom2Uncvmice
- (2015) Bing Liu et al. BMB Reports
- iRhoms in the brain – a new frontier?
- (2015) Stefan F Lichtenthaler et al. CELL CYCLE
- iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
- (2015) Xue Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17
- (2015) Sathish K. Maney et al. Science Signaling
- iRhom1 regulates proteasome activity via PAC1/2 under ER stress
- (2015) WonJae Lee et al. Scientific Reports
- Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17
- (2015) Sathish K. Maney et al. Science Signaling
- The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles
- (2014) Matthew Freeman Annual Review of Cell and Developmental Biology
- Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1 in Breast Cancer
- (2014) Z. Zhou et al. CANCER RESEARCH
- iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function
- (2014) Matthew A. Brooke et al. HUMAN MOLECULAR GENETICS
- Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
- (2014) Katie Lunnon et al. NATURE NEUROSCIENCE
- Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
- (2014) Philip L De Jager et al. NATURE NEUROSCIENCE
- iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice
- (2014) Yang Leilei et al. PLoS One
- Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin
- (2014) V. Hosur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
- (2014) O. M. Siggs et al. Biology Open
- Emerging role of rhomboid family proteins in mammalian biology and disease
- (2013) Nina Bergbold et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
- (2013) Yonka Christova et al. EMBO REPORTS
- iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding
- (2013) T. Maretzky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome
- (2012) Diana C. Blaydon et al. AMERICAN JOURNAL OF HUMAN GENETICS
- iRhom2 is required for the secretion of mouse TNF
- (2012) O. M. Siggs et al. BLOOD
- Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer
- (2012) Silva Saarinen et al. Familial Cancer
- A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes
- (2012) R. Savanh Chanthaphavong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- New lives for old: evolution of pseudoenzyme function illustrated by iRhoms
- (2012) Colin Adrain et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE
- (2012) C. Adrain et al. SCIENCE
- iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS
- (2012) D. R. McIlwain et al. SCIENCE
- Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling
- (2011) Markus Zettl et al. CELL
- Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum
- (2011) Ethan J Greenblatt et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Expanding role of ubiquitination in NF-κB signaling
- (2010) Siqi Liu et al. CELL RESEARCH
- The STING pathway and regulation of innate immune signaling in response to DNA pathogens
- (2010) Hiroki Ishikawa et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The structural basis for catalysis and substrate specificity of a rhomboid protease
- (2010) Kutti R Vinothkumar et al. EMBO JOURNAL
- The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
- (2010) Paul Saftig et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site
- (2010) S. M. Le Gall et al. JOURNAL OF CELL SCIENCE
- Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells
- (2008) Huafei Zou et al. FASEB JOURNAL
- Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth
- (2008) Zhenwen Yan et al. MOLECULAR CANCER THERAPEUTICS
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