Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

Proteomic analysis of differentially expressed skin proteins in iRhom2Uncvmice

(2015) Bing Liu et al.   BMB Reports

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

(2015) C J Kearney et al.   CELL DEATH AND DIFFERENTIATION

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into Desmosome Biology from Inherited Human Skin Disease and Cardiocutaneous Syndromes

(2014) Daniela Nitoiu et al.   CELL COMMUNICATION AND ADHESION

IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV

(2014) M Grusdat et al.   CELL DEATH AND DIFFERENTIATION

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function

(2014) Matthew A. Brooke et al.   HUMAN MOLECULAR GENETICS

iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

(2014) Yang Leilei et al.   PLoS One

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

(2014) V. Hosur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

(2014) O. M. Siggs et al.   Biology Open

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

(2013) K Azijli et al.   CELL DEATH AND DIFFERENTIATION

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

Rhomboid proteins: a role in keratinocyte proliferation and cancer

(2012) Sarah L. Etheridge et al.   CELL AND TISSUE RESEARCH

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

(2012) Silva Saarinen et al.   Familial Cancer

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

(2011) N Vanlangenakker et al.   Cell Death & Disease

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

(2011) Thorsten Maretzky et al.   Nature Communications

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17

(2010) T Maretzky et al.   ONCOGENE

Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer

(2009) F R Hirsch et al.   ONCOGENE

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

(2008) Huafei Zou et al.   FASEB JOURNAL

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

(2008) Zhenwen Yan et al.   MOLECULAR CANCER THERAPEUTICS