Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

(2018) Liam Chung et al.   Cell Host & Microbe

Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs

(2018) Xiaoyu Pan et al.   DNA RESEARCH

Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes

(2018) Geicho Nakatsu et al.   GASTROENTEROLOGY

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

(2018) Arnoud Boot et al.   GENOME RESEARCH

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

(2018) Christine M. Dejea et al.   SCIENCE

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

(2018) Kenneth KW To et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

(2018) Nadège Bossuet-Greif et al.   mBio

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Faecal microRNAs: indicators of imbalance at the host-microbe interface?

(2018) G.M. Moloney et al.   Beneficial Microbes

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

(2018) Wei-Hung Pan et al.   Genome Medicine

Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment

(2018) Michael B. Burns et al.   PLoS Genetics

Relevance of MicroRNAs as Potential Diagnostic and Prognostic Markers in Colorectal Cancer

(2018) Grzegorz Hibner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice

(2018) Joseph Dempsey et al.   BMC GENOMICS

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer

(2018) Olabisi Oluwabukola Coker et al.   GUT

Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

(2018) Vanessa L. Hale et al.   Genome Medicine

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice

(2017) Sunny H. Wong et al.   GASTROENTEROLOGY

Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha

(2017) James M. Davison et al.   GENOME RESEARCH

The oral microbiota in colorectal cancer is distinctive and predictive

(2017) Burkhardt Flemer et al.   GUT

Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4

(2017) Kazuaki Nakata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status

(2017) Bailey C. E. Peck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells

(2017) Anna Wippermann et al.   JOURNAL OF BIOTECHNOLOGY

Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals

(2017) Mohd Iqbal Bhat et al.   NUTRITION REVIEWS

Analysis ofFusobacteriumpersistence and antibiotic response in colorectal cancer

(2017) Susan Bullman et al.   SCIENCE

Microbiome, inflammation and colorectal cancer

(2017) Ju Chen et al.   SEMINARS IN IMMUNOLOGY

Emulating Host-Microbiome Ecosystem of Human Gastrointestinal Tract in Vitro

(2017) Gun-Seok Park et al.   Stem Cell Reviews and Reports

Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3

(2017) Karlheinz Friedrich et al.   BioScience Trends

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development

(2017) Ritesh Kumar et al.   PLoS Pathogens

Emulating Host-Microbiome Ecosystem of Human Gastrointestinal Tract in Vitro

(2017) Gun-Seok Park et al.   Stem Cell Reviews and Reports

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

(2017) Julia L. Drewes et al.   npj Biofilms and Microbiomes

Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic pro-inflammatory immune responses following murine Campylobacter jejuni infection

(2017) Stefan Bereswill et al.   Scientific Reports

Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer

(2017) Rachel V. Purcell et al.   Scientific Reports

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

(2016) Franck Housseau et al.   CANCER RESEARCH

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

The Host Shapes the Gut Microbiota via Fecal MicroRNA

(2016) Shirong Liu et al.   Cell Host & Microbe

Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer

(2016) Qiaoyi Liang et al.   CLINICAL CANCER RESEARCH

Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease

(2016) Rene Cortese et al.   Epigenetics

Noncoding RNA and colorectal cancer: its epigenetic role

(2016) Yoshiaki Kita et al.   JOURNAL OF HUMAN GENETICS

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

(2016) Kimberly A. Krautkramer et al.   MOLECULAR CELL

Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer

(2016) Scott J. Bultman   MOLECULAR NUTRITION & FOOD RESEARCH

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

(2016) E Thiele Orberg et al.   Mucosal Immunology

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

(2016) J-Y Yang et al.   Mucosal Immunology

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer

(2016) Y Li et al.   ONCOGENE

Bacterially-Associated Transcriptional Remodelling in a Distinct Genomic Subtype of Colorectal Cancer Provides a Plausible Molecular Basis for Disease Development

(2016) Katie S. Lennard et al.   PLoS One

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions

(2016) Nielson T. Baxter et al.   Genome Medicine

Genetic and Transcriptional Analysis of Human Host Response to Healthy Gut Microbiota

(2016) Allison L. Richards et al.   mSystems

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

(2015) Jianbin Zhang et al.   Autophagy

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

(2015) Yoshinaga Okugawa et al.   GASTROENTEROLOGY

Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

(2015) Kosuke Mima et al.   GUT

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

(2015) Jun Yu et al.   GUT

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Gut microbiome development along the colorectal adenoma–carcinoma sequence

(2015) Qiang Feng et al.   Nature Communications

Gut mucosal microbiome across stages of colorectal carcinogenesis

(2015) Geicho Nakatsu et al.   Nature Communications

Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis

(2015) A. L. Geis et al.   Cancer Discovery

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

(2015) Lina Cekaite et al.   Oncotarget

Long noncoding RNA expression profiles in gut tissues constitute molecular signatures that reflect the types of microbes

(2015) Lunxi Liang et al.   Scientific Reports

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

(2015) Bidisha Paul et al.   Clinical Epigenetics

Site-specific programming of the host epithelial transcriptome by the gut microbiota

(2015) Felix Sommer et al.   GENOME BIOLOGY

Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

(2015) Y. B. Wei et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Quantitative Profiling of Colorectal Cancer-Associated Bacteria Reveals Associations between Fusobacterium spp., Enterotoxigenic Bacteroides fragilis (ETBF) and Clinicopathological Features of Colorectal Cancer

(2015) Katie S. Viljoen et al.   PLoS One

The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer

(2014) Lingling Xu et al.   BMC CANCER

Microbiome, Inflammation, and Cancer

(2014) Ralph Francescone et al.   CANCER JOURNAL

The Human Gut Microbiome as a Screening Tool for Colorectal Cancer

(2014) J. P. Zackular et al.   Cancer Prevention Research

Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

(2014) Antoaneta Belcheva et al.   CELL

The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients

(2014) Annemarie Boleij et al.   CLINICAL INFECTIOUS DISEASES

Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome

(2014) L. Flanagan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

miRNA as markers for the diagnostic screening of colon cancer

(2014) Farid E Ahmed   Expert Review of Anticancer Therapy

Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape

(2014) J. Gray Camp et al.   GENOME RESEARCH

Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect

(2014) Xingmin Wang et al.   GUT

Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma

(2014) Lihua Li et al.   JOURNAL OF PATHOLOGY

The Multifaceted Role of the Intestinal Microbiota in Colon Cancer

(2014) Thergiory Irrazábal et al.   MOLECULAR CELL

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Microbiota organization is a distinct feature of proximal colorectal cancers

(2014) Christine M. Dejea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer

(2014) Janelle C. Arthur et al.   Nature Communications

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

(2014) D. R. Donohoe et al.   Cancer Discovery

Structure of the gut microbiome following colonization with human feces determines colonic tumor burden

(2014) Nielson T Baxter et al.   Microbiome

Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells

(2013) Anna Wippermann et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The detection and implication of genome instability in cancer

(2013) Larissa Pikor et al.   CANCER AND METASTASIS REVIEWS

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

(2013) E Mogilyansky et al.   CELL DEATH AND DIFFERENTIATION

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

(2013) Aleksandar D. Kostic et al.   Cell Host & Microbe

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Molecular Pathways: Gene-Environment Interactions Regulating Dietary Fiber Induction of Proliferation and Apoptosis via Butyrate for Cancer Prevention

(2013) S. J. Bultman   CLINICAL CANCER RESEARCH

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

(2013) M. Bonnet et al.   CLINICAL CANCER RESEARCH

The itinerary of Streptococcus gallolyticus infection in patients with colonic malignant disease

(2013) Annemarie Boleij et al.   LANCET INFECTIOUS DISEASES

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

(2013) Sarah Geisler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

(2013) Emmanuel Buc et al.   PLoS One

The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection

(2013) C. Archambaud et al.   mBio

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

The Gut Microbiome: A New Frontier in Autism Research

(2013) Jennifer G. Mulle et al.   Current Psychiatry Reports

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

The Murine Caecal MicroRNA Signature Depends on the Presence of the Endogenous Microbiota

(2012) Natasha Singh et al.   International Journal of Biological Sciences

Impact of lactobacilli on orally acquired listeriosis

(2012) C. Archambaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mammalian microRNA response to bacterial infections

(2012) Ana Eulalio et al.   RNA Biology

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

The IRF family of transcription factors

(2012) Hideyuki Yanai et al.   OncoImmunology

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Clinical Importance of Streptococcus gallolyticus Infection Among Colorectal Cancer Patients: Systematic Review and Meta-analysis

(2011) Annemarie Boleij et al.   CLINICAL INFECTIOUS DISEASES

4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis–Infected Macrophages

(2011) Xingmin Wang et al.   GASTROENTEROLOGY

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

(2011) M. Castellarin et al.   GENOME RESEARCH

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells

(2011) Kyoko Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbiota Modulate Host Gene Expression via MicroRNAs

(2011) Guillaume Dalmasso et al.   PLoS One

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

(2011) A. C. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease

(2011) S. Greenblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs Control Intestinal Epithelial Differentiation, Architecture, and Barrier Function

(2010) Lindsay B. McKenna et al.   GASTROENTEROLOGY

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression

(2009) B Diosdado et al.   BRITISH JOURNAL OF CANCER

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE