The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases

(2012) Anke J. Tijsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The MicroRNA-17-92 Family of MicroRNA Clusters in Development and Disease

(2012) Carla P. Concepcion et al.   CANCER JOURNAL

Microparticles: major transport vehicles for distinct microRNAs in circulation

(2012) P. Diehl et al.   CARDIOVASCULAR RESEARCH

Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene

(2012) M Díaz-Beyá et al.   LEUKEMIA

Prognostic significance of serum miR-17-5p in lung cancer

(2012) Qun Chen et al.   MEDICAL ONCOLOGY

miRNA Profiling in Colorectal Cancer Highlights miR-1 Involvement in MET-Dependent Proliferation

(2012) J. F. Reid et al.   MOLECULAR CANCER RESEARCH

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

(2012) Gabriel B. Loeb et al.   MOLECULAR CELL

Integration of MicroRNA Databases to Study MicroRNAs Associated with Multiple Sclerosis

(2012) Charlotte Angerstein et al.   MOLECULAR NEUROBIOLOGY

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

An alternative mode of microRNA target recognition

(2012) Sung Wook Chi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

(2012) A L Smith et al.   ONCOGENE

Combinatorial Action of miRNAs Regulates Transcriptional and Post-Transcriptional Gene Silencing following in vivo PNS Injury

(2012) Tadepalli Adilakshmi et al.   PLoS One

MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme

(2012) S.-S. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis

(2012) S Gupta et al.   Cell Death & Disease

The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines

(2012) Rebecca L. Skalsky et al.   PLoS Pathogens

The miR-17-92 MicroRNA Cluster Is Regulated by Multiple Mechanisms in B-Cell Malignancies

(2011) Ming Ji et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation

(2011) S. Jiang et al.   BLOOD

Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways

(2011) E. Surdziel et al.   BLOOD

MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice

(2011) A. Meenhuis et al.   BLOOD

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

(2011) Venugopal Thayanithy et al.   BONE

Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer

(2011) R Morimura et al.   BRITISH JOURNAL OF CANCER

MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

(2011) T. A. Farazi et al.   CANCER RESEARCH

miR-20a Encoded by the miR-17-92 Cluster Increases the Metastatic Potential of Osteosarcoma Cells by Regulating Fas Expression

(2011) G. Huang et al.   CANCER RESEARCH

miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer

(2011) Akihiko Tsuchida et al.   CANCER SCIENCE

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

MicroRNAs Are Independent Predictors of Outcome in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP

(2011) A. J. Alencar et al.   CLINICAL CANCER RESEARCH

MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease

(2011) Nicole Schonrock et al.   EXPERIMENTAL NEUROLOGY

miR than meets the eye

(2011) J. Sage et al.   GENES & DEVELOPMENT

miR-17 92 cooperates with RB pathway mutations to promote retinoblastoma

(2011) K. Conkrite et al.   GENES & DEVELOPMENT

Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer

(2011) Niels H.H. Heegaard et al.   INTERNATIONAL JOURNAL OF CANCER

Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer

(2011) Ge Yu et al.   JOURNAL OF SURGICAL ONCOLOGY

Stromal cells and CD40 ligand (CD154) alter the miRNome and induce miRNA clusters including, miR-125b/miR-99a/let-7c and miR-17-92 in chronic lymphocytic leukaemia

(2011) S Willimott et al.   LEUKEMIA

miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies

(2011) Yu-Hong Cui et al.   MOLECULAR BIOLOGY OF THE CELL

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

(2011) Loïc de Pontual et al.   NATURE GENETICS

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

(2011) Shivendra Kishore et al.   NATURE METHODS

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

(2011) Anthony K L Leung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specific sequence determinants of miR-15/107 microRNA gene group targets

(2011) Peter T. Nelson et al.   NUCLEIC ACIDS RESEARCH

Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer

(2011) K Kim et al.   ONCOGENE

MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia

(2011) E. Moussay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes

(2011) Michiyo Ohyashiki et al.   Immunity & Ageing

miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells

(2010) X. Fan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

(2010) Matthias Hackl et al.   AGING CELL

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

miR-17–92 cluster: ups and downs in cancer and aging

(2010) Johannes Grillari et al.   BIOGERONTOLOGY

The VHL-dependent regulation of microRNAs in renal cancer

(2010) Calida S Neal et al.   BMC Medicine

The Myc-miR-17 92 Axis Blunts TGF  Signaling and Production of Multiple TGF -Dependent Antiangiogenic Factors

(2010) M. Dews et al.   CANCER RESEARCH

let-7 and miR-17-92: Small-sized major players in lung cancer development

(2010) Hirotaka Osada et al.   CANCER SCIENCE

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

MicroRNAs Add a New Dimension to Cardiovascular Disease

(2010) Eric M. Small et al.   CIRCULATION

Circulating MicroRNAs in Patients With Coronary Artery Disease

(2010) Stephan Fichtlscherer et al.   CIRCULATION RESEARCH

Bmp Signaling Regulates Myocardial Differentiation from Cardiac Progenitors Through a MicroRNA-Mediated Mechanism

(2010) Jun Wang et al.   DEVELOPMENTAL CELL

Altered expression of miR-17-5p in CD4+lymphocytes of relapsing-remitting multiple sclerosis patients

(2010) Raija L. P. Lindberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumorigenicity of the miR-17-92 cluster distilled

(2010) G. van Haaften et al.   GENES & DEVELOPMENT

Reprogramming of miRNA networks in cancer and leukemia

(2010) S. Volinia et al.   GENOME RESEARCH

The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases

(2010) John R. Finnerty et al.   JOURNAL OF MOLECULAR BIOLOGY

Altered miRNA expression in T regulatory cells in course of multiple sclerosis

(2010) Giuseppe De Santis et al.   JOURNAL OF NEUROIMMUNOLOGY

Decoy for microRNAs

(2010) Isidore Rigoutsos et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans

(2010) Dimitrios G Zisoulis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Desperately seeking microRNA targets

(2010) Marshall Thomas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

(2010) Johannes H. Schulte et al.   NUCLEIC ACIDS RESEARCH

Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development

(2010) Masatoshi Shigoka et al.   PATHOLOGY INTERNATIONAL

MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood

(2010) Mathew B. Cox et al.   PLoS One

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling

(2010) Z. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYCN-regulated microRNAs repress estrogen receptor-  (ESR1) expression and neuronal differentiation in human neuroblastoma

(2010) J. Loven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

The impact of noncoding RNA on the biochemical and molecular mechanisms of aging

(2009) David J. Bates et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression

(2009) B Diosdado et al.   BRITISH JOURNAL OF CANCER

New Tricks for Animal MicroRNAs: Targeting of Amino Acid Coding Regions at Conserved and Nonconserved Sites

(2009) I. Rigoutsos   CANCER RESEARCH

Role of themiR-106b-25microRNA cluster in hepatocellular carcinoma

(2009) Yang Li et al.   CANCER SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

microRNAs and the immune response

(2009) Eleni Tsitsiou et al.   CURRENT OPINION IN PHARMACOLOGY

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution

(2009) Gianni Carraro et al.   DEVELOPMENTAL BIOLOGY

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas

(2009) P. Mu et al.   GENES & DEVELOPMENT

miR-19 is a key oncogenic component of mir-17-92

(2009) V. Olive et al.   GENES & DEVELOPMENT

Chromatin poises miRNA- and protein-coding genes for expression

(2009) A. Barski et al.   GENOME RESEARCH

Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening

(2009) E K O Ng et al.   GUT

MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy

(2009) Monika Jung et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The miR-17-92 Cluster is Over Expressed in and Has an Oncogenic Effect on Renal Cell Carcinoma

(2009) Tsz-fung F. Chow et al.   JOURNAL OF UROLOGY

miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition Elements

(2009) Ashish Lal et al.   MOLECULAR CELL

Revisiting the principles of microRNA target recognition and mode of action

(2009) Peter Brodersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines

(2009) S-K Leivonen et al.   ONCOGENE

Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients

(2009) David Otaegui et al.   PLoS One

ThemiR-17∼92cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

(2009) Tamar Uziel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Alterations of the microRNA network cause neurodegenerative disease

(2009) Sébastien S. Hébert et al.   TRENDS IN NEUROSCIENCES

Elevated Expression of the miR-17–92 Polycistron and miR-21 in Hepadnavirus-Associated Hepatocellular Carcinoma Contributes to the Malignant Phenotype

(2008) Erin Connolly et al.   AMERICAN JOURNAL OF PATHOLOGY

The Origins of Medulloblastoma Subtypes

(2008) Richard J. Gilbertson et al.   Annual Review of Pathology-Mechanisms of Disease

Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage

(2008) Sergei B. Koralov et al.   CELL

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

Chromatin structure analyses identify miRNA promoters

(2008) F. Ozsolak et al.   GENES & DEVELOPMENT

Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis

(2008) N. S. Sokol et al.   GENES & DEVELOPMENT

Genotype-phenotype correlations in MYCN-related Feingold syndrome

(2008) Carlo L.M. Marcelis et al.   HUMAN MUTATION

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

(2008) Yvonne Tay et al.   NATURE

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

(2008) Laura Fontana et al.   PLoS One

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

(2008) J. J. Forman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

(2008) K. Abdelmohsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYCN regulates oncogenic MicroRNAs in neuroblastoma

(2007) Johannes H. Schulte et al.   INTERNATIONAL JOURNAL OF CANCER