The colibactin warhead crosslinks DNA

Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways

(2014) Philipp Engel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli

(2014) I. Marcq et al.   JOURNAL OF INFECTIOUS DISEASES

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

(2014) G. Schneditz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer

(2014) Janelle C. Arthur et al.   Nature Communications

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

(2013) Xiaoying Bian et al.   CHEMBIOCHEM

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides

(2013) Daniela Reimer et al.   NATURAL PRODUCT REPORTS

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

Studies on activation mechanism of a mitomycin dimer, 7-N,7′-N′-(1″,2″-dithiepanyl-3″,7″-dimethylenyl)bismitomycin C

(2012) Jae Jin Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Analysis of Structure–Function Relationships in the Colibactin-Maturating Enzyme ClbP

(2012) Antony Cougnoux et al.   JOURNAL OF MOLECULAR BIOLOGY

Escherichia coli strains with the capacity for long-term persistence in the bowel microbiota carry the potentially genotoxic pks island

(2012) Forough L. Nowrouzian et al.   MICROBIAL PATHOGENESIS

Target analysis of α-alkylidene-γ-butyrolactones in uropathogenic E. coli

(2012) Martin H. Kunzmann et al.   Molecular BioSystems

Mass spectral molecular networking of living microbial colonies

(2012) J. Watrous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis

(2011) Christopher J. Thibodeaux et al.   CHEMICAL REVIEWS

ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides

(2011) Damien Dubois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A natural prodrug activation mechanism in nonribosomal peptide synthesis

(2011) Daniela Reimer et al.   Nature Chemical Biology

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA interstrand crosslink repair in mammalian cells: step by step

(2009) Parameswary A Muniandy et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Fundamental Relationships between Structure, Reactivity, and Biological Activity for the Duocarmycins and CC-1065

(2009) Karen S. MacMillan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the Complete Zwittermicin A Biosynthesis Gene Cluster from Bacillus cereus

(2008) B. M. Kevany et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY