N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

(2012) Guadalupe-Miroslava Suarez-Jimenez et al.   Marine Drugs

Synthesis of N-methylated cyclic peptides

(2012) Jayanta Chatterjee et al.   Nature Protocols

Chemical Approaches To Understand the Language of Histone Modifications

(2011) Abhinav Dhall et al.   ACS Chemical Biology

Increasing αvβ3 Selectivity of the Anti-Angiogenic Drug Cilengitide by N-Methylation

(2011) Carlos Mas-Moruno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53

(2011) Jirouta Kitagaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Per-N-methylated analogues of an antitumor bicyclic hexapeptide RA-VII

(2011) Yukio Hitotsuyanagi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

(2011) Yusuke Yamagishi et al.   CHEMISTRY & BIOLOGY

The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides

(2011) Oded Ovadia et al.   MOLECULAR PHARMACEUTICS

Rethinking amide bond synthesis

(2011) Vijaya R. Pattabiraman et al.   NATURE

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Solid-Phase Synthesis of NMe-IB-01212, a Highly N-Methylated Cyclic Peptide

(2011) Eleonora Marcucci et al.   ORGANIC LETTERS

Phase II Study of Plitidepsin 3-Hour Infusion Every 2 Weeks in Patients With Unresectable Advanced Medullary Thyroid Carcinoma

(2010) Eric Baudin et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Identification of Protein N-Terminal Methyltransferases in Yeast and Humans

(2010) Kristofor J. Webb et al.   BIOCHEMISTRY

Deletion of Ac-NMePhe1 from [NMePhe1]arodyn under acidic conditions, part 2: Effects of cleavage conditions and N-terminal functionality

(2010) Wei-Jie Fang et al.   BIOPOLYMERS

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins

(2010) Burkhardt Laufer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Phase II Clinical and Pharmacokinetic Study of Plitidepsin 3-Hour Infusion Every Two Weeks Alone or with Dexamethasone in Relapsed and Refractory Multiple Myeloma

(2010) M. V. Mateos et al.   CLINICAL CANCER RESEARCH

Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions

(2010) Xiangyang Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MultipleN-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies

(2010) Lucas Doedens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclodepsipeptides from Marine Sponges: Natural Agents for Drug Research

(2010) Gowri Shankar Bagavananthem Andavan et al.   Marine Drugs

NRMT is an α-N-methyltransferase that methylates RCC1 and retinoblastoma protein

(2010) Christine E. Schaner Tooley et al.   NATURE

Interaction of an echinomycin–DNA complex with manganese ions

(2009) Roland Pfoh et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

NMe Amide as a Synthetic Surrogate for the Thioester Moiety in Thiocoraline

(2009) Judit Tulla-Puche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase II Randomized Study of Plitidepsin (Aplidin), Alone or in Association with L-carnitine, in Patients with Unresectable Advanced Renal Cell Carcinoma

(2009) Patrick Schöffski et al.   Marine Drugs

Phase II Study of Biweekly Plitidepsin as Second-Line Therapy for Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium

(2009) Herlinde Dumez et al.   Marine Drugs

Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma

(2009) Tim Eisen et al.   MELANOMA RESEARCH

Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

(2009) G. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Apoptosis induced by enniatins H and MK1688 isolated from Fusarium oxysporum FB1501

(2009) Usok Hyun et al.   TOXICON

Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic

(2008) Aleksandra Velkova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1

(2008) Yi Hao et al.   JOURNAL OF CELL BIOLOGY

Comprehensive Study of Sansalvamide A Derivatives and their Structure–Activity Relationships against Drug-Resistant Colon Cancer Cell Lines

(2008) Katerina Otrubova et al.   JOURNAL OF MEDICINAL CHEMISTRY

CanN-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?

(2008) Burkhardt Laufer et al.   JOURNAL OF PEPTIDE SCIENCE

Ribosomal Synthesis ofN-Methyl Peptides

(2008) Alexander O. Subtelny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Is there a code embedded in proteins that is based on post-translational modifications?

(2008) Robert J. Sims et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity

(2008) M. J. Feige et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Preference and Potential Templates ofN-Methylated Cyclic Pentaalanine Peptides

(2007) Jayanta Chatterjee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cysteine-S-trityl a Key Derivative to PrepareN-Methyl Cysteines

(2007) Eleonora Marcucci et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Phase II study of plitidepsin in pretreated patients with locally advanced or metastatic non-small cell lung cancer

(2007) Christian Peschel et al.   LUNG CANCER