Integrin modulators: a patent review

 1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

(2013) W. S. Carbonell et al.   CANCER RESEARCH

A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion

(2013) Florian Rechenmacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids

(2013) Alexander Bochen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Phase 2 Randomized, Double-Masked, Placebo-Controlled Study of a Novel Integrin Antagonist (SAR 1118) for the Treatment of Dry Eye

(2012) Charles P. Semba et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro

(2012) Florian Rechenmacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of LFA-1/ICAM-1-mediated cell adhesion by stilbene derivatives from Rheum undulatum

(2012) Seung Woong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts

(2012) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis

(2012) Paul J Rutgeerts et al.   GUT

Vedolizumab for the treatment of ulcerative colitis and Crohn’s disease

(2012) Leon P McLean et al.   Immunotherapy

Mapping of Potent and Specific Binding Motifs, GLOGEN and GVOGEA, for Integrin α1β1 Using Collagen Toolkits II and III

(2012) Samir W. Hamaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) David H Miller et al.   LANCET NEUROLOGY

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

The role of β3-integrins in tumor angiogenesis: context is everything

(2011) Stephen D Robinson et al.   CURRENT OPINION IN CELL BIOLOGY

Volociximab in cancer

(2011) Salah Almokadem et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Integrin α3β1 as a breast cancer target

(2011) Sita Subbaram et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies

(2011) David A Reardon et al.   Future Oncology

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Vedolizumab for the Treatment of Active Ulcerative Colitis: A Randomized Controlled Phase 2 Dose-ranging Study

(2011) Asit Parikh et al.   INFLAMMATORY BOWEL DISEASES

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Evaluation of the safety, pharmacokinetics and treatment effects of an ανβ3integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases

(2010) Mark A ROSENTHAL et al.   Asia-Pacific Journal of Clinical Oncology

A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin αvβ3, ± dacarbazine in patients with stage IV metastatic melanoma

(2010) Peter Hersey et al.   CANCER

Endothelial  5 and  v integrins cooperate in remodeling of the vasculature during development

(2010) A. van der Flier et al.   DEVELOPMENT

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

An LFA-1 ( L 2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis

(2010) S. J. Suchard et al.   JOURNAL OF IMMUNOLOGY

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization

(2009) Grit Zahn   ARCHIVES OF OPHTHALMOLOGY

Role of integrin-mediated TGFβ activation in the pathogenesis of pulmonary fibrosis

(2009) Amanda Goodwin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited

(2009) Sonja Loges et al.   CANCER CELL

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

Will integrin inhibitors have proangiogenic effects in the clinic?

(2009) Michael Weller et al.   NATURE MEDICINE

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Antibody-Mediated Blockade of Integrin  v 6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor- Regulated Mechanism

(2008) L. A. Koopman Van Aarsen et al.   CANCER RESEARCH

Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor

(2008) Dominik Heckmann et al.   CHEMBIOCHEM

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY