Journal
PROGRESS IN POLYMER SCIENCE
Volume 39, Issue 7, Pages 1312-1347Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2013.11.006
Keywords
Conformation; Orientation; Bioconjugation; Attachment; Immobilization; Bio-orthogonal
Categories
Funding
- Australian Postgraduate Award
- Cooperative Research Centre for Polymers
- Australian Research Council
- NHMRC [APP1050684]
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Cells respond to their environment in complex and sometimes poorly understood ways. Protein, peptide and synthetic peptidomimetic ligands may all be used to stimulate cells via receptor signaling, using interactions that are often highly specific. Polymer substrates that present these ligands provide a promising way to control cell development, both for applications in biotechnology and for fundamental studies of cell biology. Here we review a large range of techniques that have been employed to create and characterize ligand-functionalized substrates, with a particular focus on techniques that allow specific and consistent stimulation. (C) 2013 Elsevier Ltd. All rights reserved.
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