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Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

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Crystal structure of the MOP flippase MurJ in an inward-facing conformation

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Crystal structure of the MOP flippase MurJ in an inward-facing conformation

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Impact of the β-Lactam Resistance Modifier (−)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus

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Lantibiotic Resistance

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A new antibiotic kills pathogens without detectable resistance

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A subset of annular lipids is linked to the flippase activity of an ABC transporter

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MurJ and a novel lipid II flippase are required for cell wall biogenesis inBacillus subtilis

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Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

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Membrane proteins bind lipids selectively to modulate their structure and function

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MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

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Structural insights into H+-coupled multidrug extrusion by a MATE transporter

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Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

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The Bacterial Cell Envelope

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An oldie but a goodie – cell wall biosynthesis as antibiotic target pathway

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A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface

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