Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology

A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells

(2019) Patricia Martín-Rodríguez et al.   Frontiers in Pharmacology

Polycythemia Vera

(2018) Jerry L. Spivak   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

(2018) Bettina Wingelhofer et al.   LEUKEMIA

The complex roles of STAT3 and STAT5 in maintaining redox balance: Lessons from STAT-mediated xCT expression in cancer cells

(2017) Katja Linher-Melville et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Understanding of leukemic stem cells and their clinical implications

(2017) Xuefei Wang et al.   Molecular Cancer

FLT3 inhibitors: clinical potential in acute myeloid leukemia

(2017) Marie-Anne Hospital et al.   OncoTargets and Therapy

Responses to Cytokines and Interferons that Depend upon JAKs and STATs

(2017) George R. Stark et al.   Cold Spring Harbor Perspectives in Biology

Analysis of the mutational landscape of classic Hodgkin lymphoma identifies disease heterogeneity and potential therapeutic targets

(2017) Elena Mata et al.   Oncotarget

Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases

(2016) Malgorzata Szelag et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

(2016) Borja Guerra et al.   Oncotarget

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

The identification and characterization of a STAT5 gene signature in hematologic malignancies

(2015) Dmitriy Sonkin et al.   Cancer Biomarkers

Tyrosine Kinase Inhibitor–Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia

(2015) Javid J. Moslehi et al.   JOURNAL OF CLINICAL ONCOLOGY

Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway

(2015) Ly Quoc Trung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

(2015) Srividya Swaminathan et al.   NATURE IMMUNOLOGY

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells

(2015) Ivana Campia et al.   PLoS One

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia

(2015) Wolfgang Warsch et al.   Oncotarget

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

(2014) S. Bibi et al.   HAEMATOLOGICA

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

(2014) Abbarna A. Cumaraswamy et al.   ACS Medicinal Chemistry Letters

Adding a new facet to STAT5 in CML: Multitasking for leukemic cells

(2013) Wolfgang Warsch et al.   CELL CYCLE

Immunologic pathomechanism of Hodgkin's lymphoma

(2013) Adam Jona et al.   EXPERIMENTAL HEMATOLOGY

STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

(2013) K A Dorritie et al.   LEUKEMIA

FLT3tyrosine kinase inhibitors in acute myeloid leukemia: clinical implications and limitations

(2013) Sabine Kayser et al.   LEUKEMIA & LYMPHOMA

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth

(2013) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice

(2012) C. Walz et al.   BLOOD

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

(2012) S. K. Tasian et al.   BLOOD

The role of STAT5 in lymphocyte development and transformation

(2012) Lynn M Heltemes-Harris et al.   CURRENT OPINION IN IMMUNOLOGY

Biology and significance of the JAK/STAT signalling pathways

(2012) Hiu Kiu et al.   GROWTH FACTORS

Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR–ABL-positive cells

(2012) N Chatain et al.   ONCOGENE

Critical requirement for Stat5 in a mouse model of polycythemia vera

(2011) D. Yan et al.   BLOOD

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia

(2011) W. Warsch et al.   BLOOD

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

(2011) E. A. Nelson et al.   BLOOD

Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression

(2011) Jingping Sun et al.   LEUKEMIA RESEARCH

Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells

(2010) Buket Kosova et al.   LEUKEMIA & LYMPHOMA

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

(2010) Jung-Hyun Park et al.   NATURE IMMUNOLOGY

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation

(2009) Roslyn A Kemp et al.   IMMUNOLOGY AND CELL BIOLOGY

Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia

(2009) A Hochhaus et al.   LEUKEMIA

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

(2009) Stephen Malin et al.   NATURE IMMUNOLOGY

IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis

(2008) F. A. Scheeren et al.   BLOOD

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1

(2008) M. A. Kerenyi et al.   BLOOD

Imatinib for Newly Diagnosed Patients With Chronic Myeloid Leukemia: Incidence of Sustained Responses in an Intention-to-Treat Analysis

(2008) Hugues de Lavallade et al.   JOURNAL OF CLINICAL ONCOLOGY

Maximal STAT5-Induced Proliferation and Self-Renewal at Intermediate STAT5 Activity Levels

(2008) A. T. J. Wierenga et al.   MOLECULAR AND CELLULAR BIOLOGY

JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies

(2008) William Vainchenker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inteferons pen the JAK–STAT pathway

(2008) Christian Schindler et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expression

(2007) Seungchan Yang et al.   EXPERIMENTAL CELL RESEARCH