Article
Biochemistry & Molecular Biology
Sicong Wang, Erin Clapper, Kathryn F. Tonissen, Giovanna Di Trapani
Summary: Diffuse large B-cell lymphoma (DLBCL), the most diagnosed non-Hodgkin's lymphoma subtype, is associated with high expression levels of the Trx system and BCR signalling pathway. This study demonstrates that co-targeting BTK and TrxR with [Au(d2pype)(2)]Cl and ibrutinib respectively, shows synergistic effects on the inhibition of lymphoma cell proliferation, activation of apoptosis, and, depending on lymphoma cell subtype, induction of ferroptosis. Additionally, the combination treatment also inhibits the NF-kappa B pathway. Thus, a combination approach targeting BTK and TrxR may be a promising therapeutic strategy for DLBCL.
Review
Hematology
Shazia Nakhoda, Aldana Vistarop, Y. Lynn Wang
Summary: Bruton tyrosine kinase inhibitors (BTKi) have had a significant impact on the treatment of chronic lymphocytic leukaemia (CLL) and non-Hodgkin lymphoma. However, resistance to BTKi remains a challenge, and this review article provides an update on the key clinical data, mechanisms of resistance, and ongoing clinical investigations in CLL, mantle cell lymphoma, and diffuse large B-cell lymphoma (DLBCL).
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Manzar Alam, Sabeeha Ali, Taj Mohammad, Gulam Mustafa Hasan, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Summary: Defects in apoptosis mechanism can enhance cancer cell growth and survival. Bcl-2, as an important anti-apoptotic molecule, is over-expressed in various cancers and has become a target for novel anti-tumor treatments. BH3-mimetics are emerging as promising compounds for cancer therapy, with ongoing clinical trials targeting Bcl-2 for multiple cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Tomohiro Aoki, Christian Steidl
Summary: The emergence and rapid development of single-cell technologies have transformed cancer research, providing powerful tools to understand cellular heterogeneity and interactions at the single-cell level. Recent advances in single-cell RNA sequencing have improved our understanding of lymphoma, particularly classical Hodgkin lymphoma (CHL), by revealing heterogeneity in malignant cell differentiation states and the composition of the tumor microenvironment (TME). These technologies hold promise for biomarker discovery and immunotherapeutic development for lymphoma treatment.
Article
Biochemistry & Molecular Biology
Si Li, Bin Wu, Xu Zheng, Changyuan Wang, Jingyuan Zhao, Huijun Sun, Xiuli Sun, Zeyao Tang, Hong Yuan, Lixue Chen, Xiaodong Ma
Summary: A new series of BTK inhibitors, IAAPs, show promising anti-proliferative activity against AML and B-cell lymphoma cell lines with low cytotoxicity. Compounds 11a and 11b induced significant apoptosis in these cells by arresting the cell cycle and blocking BTK autophosphorylation and prosurvival signaling. These findings suggest that 11a and 11b may be valuable preclinical candidates for the treatment of AML and B-cell lymphoma.
BIOORGANIC CHEMISTRY
(2021)
Article
Hematology
Yazeed Sawalha, Subir Goyal, Jeffrey M. Switchenko, Jason T. Romancik, Manali Kamdar, I. Brian Greenwell, Brian T. Hess, Krista M. Isaac, Craig A. Portell, Alex Mejia Garcia, Scott Goldsmith, Natalie S. Grover, Peter A. Riedel, Reem Karmali, Madelyn Burkart, Michael Buege, Othman Akhtar, Pallawi Torka, Anita Kumar, Brian T. Hill, Brad S. Kahl, Jonathon B. Cohen
Summary: This study reports the efficacy of venetoclax in patients with relapsed mantle cell lymphoma (MCL). Venetoclax monotherapy or combination therapy with other active agents showed good overall response rate (ORR) and short progression-free survival (PFS) in MCL patients.
Article
Multidisciplinary Sciences
Dhananjaya Pal, Kendra R. Vann, Shweta Joshi, Namood E. Sahar, Guillermo A. Morales, Dalia El-Gamal, Tatiana G. Kutateladze, Donald L. Durden
Summary: The study developed a first-in-class inhibitor SRX3262 that simultaneously blocks three driver pathways of MCL and overcomes resistance. The inhibitor destabilizes c-MYC, induces apoptosis, providing a new approach to treat MCL.
Article
Oncology
Wei Wei, Zhihui Song, Masahiro Chiba, Wenjun Wu, Subin Jeong, Jing-Ping Zhang, Marshall E. Kadin, Masao Nakagawa, Yibin Yang
Summary: This study reveals the distinct roles of EP300 and CREBBP in ALCL and HL, with EP300 directly modulating the expression of oncogenes and immune-related molecules. The use of EP300/CREBBP inhibitors shows strong activities against ALCL and HL cells and inhibits tumor immune escape through PD-L1.
Article
Oncology
Hildo C. Lantermans, Marthe Minderman, Annemieke Kuil, Marie-Jose Kersten, Steven T. Pals, Marcel Spaargaren
Summary: The aberrant expression of the SRC-family tyrosine kinase HCK is associated with poor prognosis in MCL patients and can be controlled by the TLR/MYD88 pathway. Silencing of HCK leads to cell cycle arrest and apoptosis in MCL cells.
Article
Dermatology
Sara Peru, Martina Prochazkova-Carlotti, Floriane Cherrier, Joanne Velazquez, Elodie Richard, Yamina Idrissi, David Cappellen, Lamia Azzi-Martin, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio, Sandrine Poglio
Summary: Cutaneous T-cell lymphoma (CTCL) is characterized by abnormal infiltration of T lymphocytes in the skin. In this study, the researchers found that the expression of cutaneous lymphocyte antigen (CLA) in CTCL cells is crucial for their migration and survival. The use of a CLA antibody significantly reduced the migration and survival of CTCL cells both in vitro and in vivo. These findings suggest that inhibiting CLA could be a potential therapeutic strategy for CTCL patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Tingting Qiu, Luan Hu, Yongtian Zhang, Ying Wang, Sha Ma, Depeng Li, Zhenyu Li, Kailin Xu
Summary: The study aimed to determine the clinical characteristics of cytopenia in patients with relapsed and refractory B-cell non-Hodgkin lymphoma (B-NHL) treated with CAR-T therapy. A total of 63 patients were retrospectively analyzed, and neutropenia, anemia, and thrombocytopenia occurred in 76.19%, 25.39%, and 23.80% cases, respectively. Baseline absolute neutrophil count (ANC) and hemoglobin concentration were identified as independent risk factors for severe cytopenia. Additionally, 35% of patients did not recover from cytopenia at day +28 after infusion, and baseline ANC and hemoglobin levels were found to affect hemocyte recovery.
Article
Immunology
Chai Teng Chear, Intan Hakimah Ismail, Kwai Cheng Chan, Lokman Mohd Noh, Asiah Kassim, Amir Hamzah Abdul Latiff, Sandeep Singh Gill, Nazatul Haslina Ramly, Kah Kee Tan, Charlotte Sundaraj, Chong Ming Choo, Sharifah Adlena Syed Mohamed, Mohd Farid Baharin, Amelia Suhana Zamri, Sharifah Nurul Husna Syed Yahya, Saharuddin Bin Mohamad, Adiratna Mat Ripen
Summary: This article provides an overview of demographic, clinical, immunological, and genetic data of XLA patients in Malaysia, which serves as a basis for the diagnosis and genetic counseling of XLA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Shaghayegh Khanmohammadi, Parisa Fallahtafti
Summary: This systematic review evaluates the role of long non-coding RNAs (lncRNAs) in aggressive B-cell non-Hodgkin lymphoma (NHL) and finds that lncRNAs have potential as biomarkers for diagnosis, prognosis, and response to therapy in this disease. At least 79 lncRNAs have been implicated in the pathogenesis of aggressive B-cell NHL, and targeting them can affect cell behavior and treatment response. Dysregulated lncRNAs also have prognostic value in patients with different subtypes of NHL. Therefore, lncRNAs could serve as promising biomarkers and therapeutic targets for aggressive B-cell NHL.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Nuria Profitos-Peleja, Juliana Carvalho Santos, Ana Marin-Niebla, Gael Roue, Marcelo Lima Ribeiro
Summary: Dysregulated BCR signaling is a crucial factor in the survival of B-NHL tumors, and BCR-targeted therapies provide alternative treatment options. However, durable responses to these drugs are often not achieved. This review discusses the role of BCR signaling in B-NHLs, the mechanisms of BCR-targeted therapies, and the development of new treatment strategies.
Article
Hematology
Clementine Sarkozy, Stacy S. Hung, Elizabeth A. Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C. Chong, Tomohiro Aoki, Aixiang Jiang, Tomoko Miyata-Takata, Adele Telenius, Graham W. Slack, Thierry Jo Molina, Susana Ben-Neriah, Pedro Farinha, Peggy Dartigues, Diane Damotte, Anja Mottok, Gilles A. Salles, Rene-Olivier Casasnovas, Kerry J. Savage, Camille Laurent, David W. Scott, Alexandra Traverse-Glehen, Christian Steidl
Summary: The mutational landscape of gray zone lymphoma (GZL) differs between cases with and without thymic niche involvement, showing distinct patterns related to apoptosis defects and BCL2/BCL6 rearrangements, respectively. Additionally, poly-EBV-L cases exhibit a unique mutational profile with STAT3 mutations and lower coding mutation load compared to EBV- GZL. These findings suggest common cell of origin and disease evolution among GZL with thymic presentation and related anterior mediastinal lymphomas.
Article
Hematology
Ferdinando Bonfiglio, Alessio Bruscaggin, Francesca Guidetti, Lodovico Terzi di Bergamo, Martin Faderl, Valeria Spina, Adalgisa Condoluci, Luisella Bonomini, Gabriela Forestieri, Ricardo Koch, Deborah Piffaretti, Katia Pini, Maria Cristina Pirosa, Micol Giulia Cittone, Alberto Arribas, Marco Lucioni, Guido Ghilardi, Wei Wu, Luca Arcaini, Maria Joao Baptista, Gabriela Bastidas, Silvia Bea, Renzo Boldorini, Alessandro Broccoli, Marco Matteo Buehler, Vincenzo Canzonieri, Luciano Cascione, Luca Ceriani, Sergio Cogliatti, Paolo Corradini, Enrico Derenzini, Liliana Devizzi, Sascha Dietrich, Angela Rita Elia, Fabio Facchetti, Gianluca Gaidano, Juan Fernando Garcia, Bernhard Gerber, Paolo Ghia, Maria Gomes da Silva, Giuseppe Gritti, Anna Guidetti, Felicitas Hitz, Giorgio Inghirami, Marco Ladetto, Armando Lopez-Guillermo, Elisa Lucchini, Antonino Maiorana, Roberto Marasca, Estella Matutes, Veronique Meignin, Michele Merli, Alden Moccia, Manuela Mollejo, Carlos Montalban, Urban Novak, David Graham Oscier, Francesco Passamonti, Francesco Piazza, Stefano Pizzolitto, Alessandro Rambaldi, Elena Sabattini, Gilles Salles, Elisa Santambrogio, Lydia Scarfo, Anastasios Stathis, Georg Stussi, Julia T. Geyer, Gustavo Tapia, Corrado Tarella, Catherine Thieblemont, Thomas Tousseyn, Alessandra Tucci, Giorgio Vanini, Carlo Visco, Umberto Vitolo, Renata Walewska, Francesco Zaja, Thorsten Zenz, Pier Luigi Zinzani, Hossein Khiabanian, Arianna Calcinotto, Francesco Bertoni, Govind Bhagat, Elias Campo, Laurence De Leval, Stefan Dirnhofer, Stefano A. Pileri, Miguel A. Piris, Alexandra Traverse-Glehen, Alexander Tzankov, Marco Paulli, Maurilio Ponzoni, Luca Mazzucchelli, Franco Cavalli, Emanuele Zucca, Davide Rossi
Summary: Splenic marginal zone B-cell lymphoma (SMZL) is a heterogeneous clinico-biological entity with different subgroups characterized by genetic abnormalities, pathway signatures, and microenvironment compositions. These findings provide insights into the classification and treatment of SMZL.
Article
Hematology
Concepcion Fernandez-Rodriguez, Juan Jose Rodriguez-Sevilla, Lierni Fernandez-Ibarrondo, Blanca Sanchez-Gonzalez, Joan Gibert, Leire Bento, Juan Fernando Garcia, Juan Manuel Sancho, Ramon Diez-Feijoo, Laura Camacho, Montserrat Garcia-Retortillo, Eva Gimeno, Luis Colomo, Antonio Gutierrez, Beatriz Bellosillo, Antonio Salar
Summary: This study reveals that hepatitis B virus infection is associated with poorer prognosis in patients with follicular lymphoma, and patients with positive anti-HBc have lower survival rates.
Article
Oncology
Laura Torresano, Fulvio Santacatterina, Sonia Dominguez-Zorita, Cristina Nuevo-Tapioles, Alfonso Nunez-Salgado, Pau B. Esparza-Molto, Lucia Gonzalez-Llorente, Ines Romero-Carraminana, Cristina Nunez de Arenas, Brenda Sanchez-Garrido, Laura Najera, Clara Salas, Mariano Provencio, Jose M. Cuezva
Summary: Lung adenocarcinoma patients' survival and disease recurrence can be predicted by the levels of mitochondrial proteins related to fatty acid oxidation, oxidative phosphorylation, and antioxidant response. Overexpression of ATPase Inhibitory Factor 1 prevents metastatic disease in lung adenocarcinoma. Targeting fatty acid assimilation or oxidation in combination with an oxidative phosphorylation inhibitor shows therapeutic potential in mice with lung adenocarcinomas.
Article
Oncology
Mariano Provencio, Roberto Serna-Blasco, Ernest Nadal, Amelia Insa, M. Rosario Garcia-Campelo, Joaquin Casal Rubio, Manuel Domine, Margarita Majem, Delvys Rodriguez-Abreu, Alex Martinez-Marti, Javier De Castro Carpeno, Manuel Cobo, Guillermo Lopez Vivanco, Edel Del Barco, Reyes Bernabe Caro, Nuria Vinolas, Isidoro Barneto Aranda, Santiago Viteri, Eva Pereira, Ana Royuela, Virginia Calvo, Javier Martin-Lopez, Francisco Garcia-Garcia, Marta Casarrubios, Fernando Franco, Estela Sanchez-Herrero, Bartomeu Massuti, Alberto Cruz-Bermudez, Atocha Romero
Summary: Neoadjuvant chemotherapy plus nivolumab demonstrates effectiveness in resectable non-small cell lung cancer. Pretreatment ctDNA levels significantly correlate with survival outcomes and outperform radiologic assessments in predicting survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Ismael Fernandez-Miranda, Lucia Pedrosa, Marta Llanos, Fernando F. Franco, Sagrario Gomez, Paloma Martin-Acosta, Francisco R. Garcia-Arroyo, Josep Guma, Beatriz Horcajo, Ana K. Ballesteros, Laura Galvez, Natividad Martinez, Miguel Marin, Silvia Sequero, Marta Navarro, Natalia Yanguas-Casas, Virginia Calvo, Antonio Rueda-Dominguez, Mariano Provencio, Margarita Sanchez-Beato
Summary: This study examined the significance of circulating tumor DNA (ctDNA) in predicting response to therapy and early disease progression in follicular lymphoma (FL) patients. The results showed that baseline ctDNA levels are associated with early disease progression and treatment response in FL.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Lucia Robado de Lope, Estela Sanchez-Herrero, Roberto Serna-Blasco, Mariano Provencio, Atocha Romero
Summary: Cancer is considered an evolutionary disease where tumor cells adapt to the environment and eventually form metastasis. Communication between tumor cells and the surrounding microenvironment via extracellular vesicles (EVs) is crucial for the success of the metastatic process. Recent studies suggest that tumor-derived EVs not only modify the microenvironment to facilitate tumor progression but also induce malignant transformation in cells outside the primary tumor. Further research is needed to understand the role of EVs in cancer progression and metastasis, which may have implications for novel cancer treatments.
MOLECULAR ONCOLOGY
(2023)
Article
Hematology
Juan Jose Rodriguez-Sevilla, Concepcion Fernandez-Rodriguez, Leyre Bento, Ramon Diez-Feijoo, Sergio Pinzon, Joan Gibert, Lierni Fernandez-Ibarrondo, Marta Lafuente, Ana Ferrer, Blanca Sanchez-Gonzalez, Eva Gimeno, Juan Sainz, Rafael Ramos, Juan F. Garcia, Lluis Colomo, Beatriz Bellosillo, Antonio Gutierrez, Antonio Salar
Summary: Four clinical or clinicogenetic-risk models were explored in patients with symptomatic FL who received frontline immunochemotherapy. The FLIPI remains the clinical risk score with higher discrimination in patients with advanced FL treated with immunochemotherapy, but the performance of the m7-FLIPI should be further investigated in patients treated with R-B.
Article
Hematology
Sara Fernandez, Jose L. Solorzano, Eva Diaz, Victoria Menendez, Lorena Maestre, Sara Palacios, Mar Lopez, Argentina Colmenero, Monica Estevez, Carlos Montalban, Angel Martinez, Giovanna Roncador, Juan F. Garcia
Summary: The therapeutic potential of JAK/STAT inhibitors in cHL is confirmed by the study, which investigated the effects of JAK/STAT pharmacological inhibition on cHL cell models using ruxolitinib. The study also identified CSF3R as a new biomarker and provided supporting genetic data and mechanistic understanding.
Letter
Dermatology
Ruth Alonso-Alonso, Marta Rodriguez, Nuria Garcia-Diaz, Laura Tomas-Roca, Jennifer Borregon, Marta Cabezuelo-Rodriguez, Marcos Rebollo-Gonzalez, Luis Gallego-Manzano, Laura Cereceda, Socorro Maria Rodriguez-Pinilla, Raul Cordoba, Juan Fernando Garcia, Juan Torre-Castro, Carmen M. Garcia-alvarez, Maria del Mar Onteniente Gomis, Raquel Rivera-Diaz, Jose Luis Rodriguez-Peralto, Jose Pedro Vaque, Pablo Luis Ortiz-Romero, Miguel a Piris
Summary: Gene profiling using a customized NanoString platform can reveal specific molecular features in routine mycosis fungoides (MF) samples. This study found that MF samples carry a signature derived from individual molecular features found in consecutive biopsies.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Bruna Calsina, Elena Pineiro-Yanez, Angel M. Martinez-Montes, Eduardo Caleiras, Angel Fernandez-Sanroman, Maria Monteagudo, Rafael Torres-Perez, Coral Fustero-Torre, Marta Pulgarin-Alfaro, Eduardo Gil, Rocio Leton, Scherezade Jimenez, Santiago Garcia-Martin, Maria Carmen Martin, Juan Maria Roldan-Romero, Javier Lanillos, Sara Mellid, Maria Santos, Alberto Diaz-Talavera, Angeles Rubio, Patricia Gonzalez, Barbara Hernando, Nicole Bechmann, Margo Dona, Maria Calatayud, Sonsoles Guadalix, Cristina Alvarez-Escola, Rita M. Regojo, Javier Aller, Maria Isabel Del Olmo-Garcia, Adria Lopez-Fernandez, Stephanie M. J. Fliedner, Elena Rapizzi, Martin Fassnacht, Felix Beuschlein, Marcus Quinkler, Rodrigo A. Toledo, Massimo Mannelli, Henri J. Timmers, Graeme Eisenhofer, Sandra Rodriguez-Perales, Orlando Dominguez, Geoffrey Macintyre, Maria Curras-Freixes, Cristina Rodriguez-Antona, Alberto Cascon, Luis J. Leandro-Garcia, Cristina Montero-Conde, Giovanna Roncador, Juan Fernando Garcia-Garcia, Karel Pacak, Fatima Al-Shahrour, Mercedes Robledo
Summary: The mechanisms of metastasis in pheochromocytoma/paraganglioma (mPPGL) are unknown. Genomic and immunogenomic profiling of mPPGL tumors reveal potential biomarkers for risk of metastasis and immunotherapy response.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Juan Carlos Caballero, Elham Askari, Nerea Carrasco, Miguel Angel Piris, Begona Perez de Camino, Laura Pardo, Javier Cornago, Jose Luis Lopez-Lorenzo, Pilar Llamas, Laura Solan
Summary: This article reports a case of a 77-year-old woman diagnosed with Waldenstrom macroglobulinemia (WM) following severe and sudden pancytopenia associated with cold agglutinin syndrome. Treatment with rituximab, corticosteroids, and cyclophosphamide was initiated to manage WM and underlying hemolysis. Despite improvements in hemolysis parameters, pancytopenia persisted and ibrutinib was started as a second-line treatment. The patient developed an uncommon invasive fungal infection (IFI) with bone marrow granulomatosis and myelofibrosis during treatment, highlighting a poor hematopoietic response and numerous complications.
Correction
Oncology
Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Daniel Boyer, Mariarita Calaminici, Amy Chadburn, John K. C. Chan, Wah Cheuk, Wee-Joo Chng, John K. Choi, Shih-Sung Chuang, Sarah E. Coupland, Magdalena Czader, Sandeep S. Dave, Daphne de Jong, Arianna Di Napoli, Ming-Qing Du, Kojo S. Elenitoba-Johnson, Judith Ferry, Julia Geyer, Dita Gratzinger, Joan Guitart, Sumeet Gujral, Marian Harris, Christine J. Harrison, Sylvia Hartmann, Andreas Hochhaus, Patty M. Jansen, Kennosuke Karube, Werner Kempf, Joseph Khoury, Hiroshi Kimura, Wolfram Klapper, Alexandra E. Kovach, Shaji Kumar, Alexander J. Lazar, Stefano Lazzi, Lorenzo Leoncini, Nelson Leung, Vasiliki Leventaki, Xiao-Qiu Li, Megan S. Lim, Wei-Ping Liu, Abner Louissaint, Andrea Marcogliese, L. Jeffrey Medeiros, Michael Michal, Roberto N. Miranda, Christina Mitteldorf, Santiago Montes-Moreno, William Morice, Valentina Nardi, Kikkeri N. Naresh, Yasodha Natkunam, Siok-Bian Ng, Ilske Oschlies, German Ott, Marie Parrens, Melissa Pulitzer, S. Vincent Rajkumar, Andrew C. Rawstron, Karen Rech, Andreas Rosenwald, Jonathan Said, Clementine Sarkozy, Shahin Sayed, Caner Saygin, Anna Schuh, William Sewell, Reiner Siebert, Aliyah R. Sohani, Ritsuro Suzuki, Reuben Tooze, Alexandra Traverse-Glehen, Francisco Vega, Beatrice Vergier, Ashutosh D. Wechalekar, Brent Wood, Luc Xerri, Wenbin Xiao, Norah Olubunmi Akinola, Yassmine Akkari, Luis M. Allende, Katsuyuki Aozasa, Iguaracyra Araujo, Luca Arcaini, Kirit M. Ardeshna, Naoko Asano, Andishe Attarbaschi, Chris M. Bacon, Sharon Louise Barrans, Tracy Batchelor, Maxime Battistella, Linda B. Baughn, Amir Behdad, Sigbjorn Berentsen, Giada Bianchi, Jacob Bledsoe, Peter Borchmann, Mark Bower, Barbara Buldini, Jan Andreas Burger, Birgit Burkhardt, Ryan D. Cassaday, Giovanni Cazzaniga, Nadine Cerf-Bensussan, Ethel Cesarman, Mammen Chandy, Jennifer R. Chapman, Bjorn Chapuy, Xueyan Chen, Chee Leong Cheng, Carlos Chiattone, Nicholas Chiorazzi, Lucy B. Cook, Wendy A. Cooper, Gregory Philip Corboy, Andrew John Cowan, Immacolata Cozzolino, Ian A. Cree, Emanuele S. G. d'Amore, Andrew John Davies, Martina Deckert, Jan Delabie, Elizabeth G. Demicco, Vikram Deshpande, Arjan Diepstra, Daan Dierickx, Kieron Dunleavy, Barbara Eichhorst, Daisuke Ennishi, David C. Fajgenbaum, Pedro Farinha, Carlos Fernandez de Larrea, Kevin E. Fisher, Jude Fitzgibbon, Melina Flanagan, Jonathan Fromm, Juan F. Garcia, William Robert Geddie, Morie Gertz, Ajay Gopal, Satish Gopal, Patricia Theresa Greipp, Alejandro Gru, Ritu Gupta, Martin-Leo Hansmann, Konnie M. Hebeda, Klaus Herfarth, Marco Herling, Olivier Hermine, Khe Hoang-Xuan, Jennelle Hodge, Shimin Hu, Yuhua Huang, Yin Pun Hung, Stephen Hunger, Hiroto Inaba, Hiroshi Inagaki, Javeed Iqbal, Kenji Ishitsuka, Noriko Iwaki, Keiji Iwatsuki, Nitin Jain, Yoon Kyung Jeon, Marshall Kadin, Sachiko Kaji, Aanchal Kakkar, Anastasios Karadimitris, Keisuke Kataoka, Seiichi Kato, Marie Jose Kersten, Rhett P. Ketterling, Ji Eun Kim, Christian P. Kratz, Robert Kridel, Sigurdur Kristinsson, Ralf Kuppers, Isinsu Kuzu, Yok-Lam, Ann Lacasce, Laurence Lamant-Rochaix, Thierry Lamy, Ola Landgren, Siddhartha Laskar, William Bradlyn Laskin, Georg Lenz, Shaoying Li, Gan Di Li, Pei Lin, Franco Locatelli, Robert Brian Lorsbach, Izidore Lossos, Thomas P. Jr Loughran, William R. Macon, Joseph J. Maleszewski, Pankaj Malhotra, Teresa Marafioti, Dai Maruyama, Alexander Marx, Sam M. Mbulaiteye, Veronique Meignin, Ester Mejstrikova, Pamela Michelow, Markku Miettinen, Rodney R. Miles, Hiroaki Miyoshi, Thierry Jo Molina, Manuela Mollejo, Shuji Momose, Tetsuya Mori, William G. Morice, Bertrand Nadel, Hirokazu Nagai, Motoo Nagane, Reena Nair, Naoya Nakamura, Atsuko Nakazawa, Samih Nasr, Andrew Gordon Nicholson, Alina Nicolae, Robert Shigeo Ohgami, Naoki Oishi, Timothy S. Olson, Nicolas Ortonne, Bruno Paiva, Qiang Pan-Hammarstrom, Mayur Parihar, Marco Paulli, Andrea Petersen, Jennifer Picarsic, Alessandro Pileri, Nicola Pimpinelli, Jose A. Plaza, Karen R. Rabin, Markus Raderer, Kanti Rai, Ulla Randen, Huilan Rao, Alistair Robson, Rosemary Rochford, Richard Rosenquist, Davide Rossi, Esther D. Rossi, Simon Rule, Grzegorz Rymkiewicz, Elena Sabattini, Vaskar Saha, Mamiko Sakata-Yanagimoto, Christian A. Sander, J. Martin Sangueza, Omar P. Sangueza, Marco Santucci, Yasuharu Sato, Akira Satou, Kristian Theo Schafernak, Fernando Schmitt, Gianpietro Semenzato, Manju Sengar, Tait Shanafelt, Kazuyuki Shimada, Graham W. Slack, Susan Slager, Riccardo Soffietti, David A. Solomon, Kostas Stamatopoulos, Christian Steidl, Stephan Stilgenbauer, Narittee Sukswai, Kengo Takeuchi, Giovanni Tallini, Junichi Tamaru, Soo-Yong Tan, Prashant Tembhare, Enrico Tiacci, Yoshiki Tokura, Olivier Tournilhac, Steven Treon, Lorenz Truemper, Kunihiro Tsukasaki, Frits van Rhee, Abraham Varghese, Maarten H. Vermeer, Philippe Vielh, Brian Walker, Michael Wang, Huan-You Wang, Zhe Wang, Takashi Watanabe, Oliver Weigert, David Wein-Stock, Sean J. Whittaker, Rein Willemze, Wilhelm Woessmann, Catherine J. Wu, Motoko Yamaguchi, Hidetaka Yamamoto, Daisuke Yamashita, Shenmiao Yang, David T. Yang, Takahiko Yasuda, Wei-Hua Yin, Yoh Zen, Sha Zhao, Wei-Li Zhao
Review
Oncology
Margarita Sanchez-Beato, Miriam Mendez, Maria Guirado, Lucia Pedrosa, Silvia Sequero, Natalia Yanguas-Casas, Luis de la Cruz-merino, Laura Galvez, Marta Llanos, Juan Fernando Garcia, Mariano Provencio
Summary: The new lymphoma classifications now include genetics, which allows for better subclassification, risk stratification, and treatment prediction. Lymphomas have few recurrent and disease-specific mutations, and most have a diverse genetic landscape with rare mutations contributing to the clinical heterogeneity of the disease. Multiple studies have identified genetic markers for diagnostics and prognosis, and next-generation sequencing is becoming a crucial tool in clinical laboratories. This review provides a guide for using next-generation sequencing in lymphoma research, discussing the genetic alterations in commonly encountered lymphoma types and proposing targeted sequencing panels for detecting mutations and copy-number alterations in B- and NK/T-cell lymphomas.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Juan Carlos Caballero, Laura Pardo, Maria Socorro Rodriguez-Pinilla, Miguel Angel Piris, Beatriz Alvarez, Laura Solan, Javier Cornago, Jose Luis Lopez-Lorenzo, Pilar Llamas, Raul Cordoba, Alberto Lopez-Garcia
Summary: This article presents a rare case of a 25-year-old patient diagnosed with human immunodeficiency virus (HIV) and the development of primary effusion lymphoma (PEL), Kaposi's sarcoma (KS), and multicentric Castleman's disease (MCD). Despite intensive treatment, the patient's condition did not improve. This case highlights the need for new therapies and research in this field.
MEDICINA-LITHUANIA
(2023)
Meeting Abstract
Oncology
J. C. Sanchez Gonzalez, B. Nunez Garcia, M. Blanco Clemente, V. Calvo de Juan, B. Cantos Sanchez de Ibarguen, M. Mendez Garcia, R. Aguado Noya, D. Ruiz de Domingo, A. Gonzalez Sanchez, M. Provencio
JOURNAL OF THORACIC ONCOLOGY
(2022)
