- Home
- Publications
- Publication Search
- Publication Details
Title
Resolving genetic heterogeneity in cancer
Authors
Keywords
-
Journal
NATURE REVIEWS GENETICS
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-03-28
DOI
10.1038/s41576-019-0114-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma
- (2018) Valeria Spina et al. BLOOD
- Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
- (2018) Charissa Kim et al. CELL
- Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing
- (2018) Anna K. Casasent et al. CELL
- Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
- (2018) Samra Turajlic et al. CELL
- Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
- (2018) Samra Turajlic et al. CELL
- Cancer: a CINful evolution
- (2018) Altea Targa et al. CURRENT OPINION IN CELL BIOLOGY
- Evolutionary history of human colitis-associated colorectal cancer
- (2018) Ann-Marie Baker et al. GUT
- Chromosomal instability drives metastasis through a cytosolic DNA response
- (2018) Samuel F. Bakhoum et al. NATURE
- Quantification of subclonal selection in cancer from bulk sequencing data
- (2018) Marc J. Williams et al. NATURE GENETICS
- Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
- (2018) Nikolaos Zacharakis et al. NATURE MEDICINE
- Harnessing Tumor Evolution to Circumvent Resistance
- (2018) Katherine L. Pogrebniak et al. TRENDS IN GENETICS
- Punctuated evolution of canonical genomic aberrations in uveal melanoma
- (2018) Matthew G. Field et al. Nature Communications
- Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
- (2018) Ben O’Leary et al. Nature Communications
- Non-random Mis-segregation of Human Chromosomes
- (2018) Joseph Thomas Worrall et al. Cell Reports
- Evolutionary Pressure against MHC Class II Binding Cancer Mutations
- (2018) Rachel Marty et al. CELL
- Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors
- (2018) Inga H. Rye et al. Molecular Oncology
- Population dynamics of normal human blood inferred from somatic mutations
- (2018) Henry Lee-Six et al. NATURE
- Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
- (2018) Diana Miao et al. NATURE GENETICS
- Detecting repeated cancer evolution from multi-region tumor sequencing data
- (2018) Giulio Caravagna et al. NATURE METHODS
- Minimal functional driver gene heterogeneity among untreated metastases
- (2018) Johannes G. Reiter et al. SCIENCE
- Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial
- (2018) Khurum H. Khan et al. Cancer Discovery
- Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
- (2018) Spencer C. Wei et al. Cancer Discovery
- Reply to ‘Neutral tumor evolution?’
- (2018) Timon Heide et al. NATURE GENETICS
- Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers
- (2018) Michael Offin et al. CLINICAL CANCER RESEARCH
- Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia
- (2017) F Nadeu et al. LEUKEMIA
- Cancer biology: Genome jail-break triggers lockdown
- (2017) Neil T. Umbreit et al. NATURE
- Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
- (2017) Ugur Sahin et al. NATURE
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
- (2017) Christopher Abbosh et al. NATURE
- Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer
- (2017) Alvin P Makohon-Moore et al. NATURE GENETICS
- Between-region genetic divergence reflects the mode and tempo of tumor evolution
- (2017) Ruping Sun et al. NATURE GENETICS
- An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer
- (2017) Yaohua Xue et al. NATURE MEDICINE
- Stratifying tissue heterogeneity with scalable single-cell assays
- (2017) Kun Zhang NATURE METHODS
- Scalable whole-genome single-cell library preparation without preamplification
- (2017) Hans Zahn et al. NATURE METHODS
- Tracking the Evolution of Non–Small-Cell Lung Cancer
- (2017) Mariam Jamal-Hanjani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia
- (2017) Andreas Hochhaus et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
- (2017) Teresa Davoli et al. SCIENCE
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- (2017) Whijae Roh et al. Science Translational Medicine
- APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability
- (2017) Laurent Sansregret et al. Cancer Discovery
- Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
- (2017) Floris Foijer et al. eLife
- The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process
- (2016) Chung-I Wu et al. Annual Review of Genetics
- Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
- (2016) Jianjun Gao et al. CELL
- Measuring cancer evolution from the genome
- (2016) Trevor A Graham et al. JOURNAL OF PATHOLOGY
- Neoantigen landscape dynamics during human melanoma–T cell interactions
- (2016) Els M. E. Verdegaal et al. NATURE
- A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
- (2016) Faiyaz Notta et al. NATURE
- Haplotyping germline and cancer genomes with high-throughput linked-read sequencing
- (2016) Grace X Y Zheng et al. NATURE BIOTECHNOLOGY
- A saltationist theory of cancer evolution
- (2016) Florian Markowetz NATURE GENETICS
- Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer
- (2016) Andrew McPherson et al. NATURE GENETICS
- Punctuated copy number evolution and clonal stasis in triple-negative breast cancer
- (2016) Ruli Gao et al. NATURE GENETICS
- Identification of neutral tumor evolution across cancer types
- (2016) Marc J Williams et al. NATURE GENETICS
- Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
- (2016) Aaron N Hata et al. NATURE MEDICINE
- Clonal genotype and population structure inference from single-cell tumor sequencing
- (2016) Andrew Roth et al. NATURE METHODS
- Highly multiplexed targeted DNA sequencing from single nuclei
- (2016) Marco L Leung et al. Nature Protocols
- Genetic drift, selection and the evolution of the mutation rate
- (2016) Michael Lynch et al. NATURE REVIEWS GENETICS
- T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- (2016) Jesse M. Zaretsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chromosome instability drives phenotypic switching to metastasis
- (2016) ChongFeng Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metastasis as an evolutionary process
- (2016) S. Turajlic et al. SCIENCE
- Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
- (2016) N. McGranahan et al. SCIENCE
- Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
- (2016) Valsamo Anagnostou et al. Cancer Discovery
- High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial
- (2016) A. Pearson et al. Cancer Discovery
- Why it is crucial to analyze non clonal chromosome aberrations or NCCAs?
- (2016) Henry H. Q. Heng et al. Molecular Cytogenetics
- Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
- (2016) Ivana Bozic et al. PLoS Computational Biology
- Selective advantage of trisomic human cells cultured in non-standard conditions
- (2016) Samuel D. Rutledge et al. Scientific Reports
- Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial
- (2015) M. Jamal-Hanjani et al. ANNALS OF ONCOLOGY
- Chromothripsis: A New Mechanism for Rapid Karyotype Evolution
- (2015) Mitchell L. Leibowitz et al. Annual Review of Genetics
- Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
- (2015) Suzanne L. Topalian et al. CANCER CELL
- Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution
- (2015) Nicholas McGranahan et al. CANCER CELL
- Quantitative evolutionary dynamics using high-resolution lineage tracking
- (2015) Sasha F. Levy et al. NATURE
- A Big Bang model of human colorectal tumor growth
- (2015) Andrea Sottoriva et al. NATURE GENETICS
- Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
- (2015) Giulia Siravegna et al. NATURE MEDICINE
- Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
- (2015) Noemi Andor et al. NATURE MEDICINE
- Subclonal diversification of primary breast cancer revealed by multiregion sequencing
- (2015) Lucy R Yates et al. NATURE MEDICINE
- G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
- (2015) Iain C Macaulay et al. NATURE METHODS
- Effect of Mutation Order on Myeloproliferative Neoplasms
- (2015) Christina A. Ortmann et al. NEW ENGLAND JOURNAL OF MEDICINE
- High burden and pervasive positive selection of somatic mutations in normal human skin
- (2015) I. Martincorena et al. SCIENCE
- Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
- (2015) Muhammed Murtaza et al. Nature Communications
- Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis
- (2015) Roland F. Schwarz et al. PLOS MEDICINE
- PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors
- (2015) Amit G Deshwar et al. GENOME BIOLOGY
- Cancer: Evolution Within a Lifetime
- (2014) Marco Gerlinger et al. Annual Review of Genetics
- Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+Breast Cancer
- (2014) David Endesfelder et al. CANCER RESEARCH
- The mitotic origin of chromosomal instability
- (2014) Samuel F. Bakhoum et al. CURRENT BIOLOGY
- Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma
- (2014) L Melchor et al. LEUKEMIA
- Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
- (2014) Peter Eirew et al. NATURE
- Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
- (2014) Dejan Juric et al. NATURE
- PyClone: statistical inference of clonal population structure in cancer
- (2014) Andrew Roth et al. NATURE METHODS
- Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
- (2014) Ivana Bozic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tug-of-war between driver and passenger mutations in cancer and other adaptive processes
- (2014) Christopher D. McFarland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
- (2014) C. Bettegowda et al. Science Translational Medicine
- SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
- (2014) Christopher A. Miller et al. PLoS Computational Biology
- Population genetics of neutral mutations in exponentially growing cancer cell populations
- (2013) Rick Durrett ANNALS OF APPLIED PROBABILITY
- High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma
- (2013) Edmund A. Mroz et al. CANCER
- Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution
- (2013) Henry H. Heng et al. CANCER AND METASTASIS REVIEWS
- Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
- (2013) Dan A. Landau et al. CELL
- Punctuated Evolution of Prostate Cancer Genomes
- (2013) Sylvan C. Baca et al. CELL
- Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome
- (2013) Teresa Davoli et al. CELL
- Gene Copy-Number Alterations: A Cost-Benefit Analysis
- (2013) Yun-Chi Tang et al. CELL
- Replication stress links structural and numerical cancer chromosomal instability
- (2013) Rebecca A. Burrell et al. NATURE
- Mutational heterogeneity in cancer and the search for new cancer-associated genes
- (2013) Michael S. Lawrence et al. NATURE
- Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
- (2013) Jessica Okosun et al. NATURE GENETICS
- Pan-cancer patterns of somatic copy number alteration
- (2013) Travis I Zack et al. NATURE GENETICS
- Large population solution of the stochastic Luria-Delbruck evolution model
- (2013) D. A. Kessler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impact of deleterious passenger mutations on cancer progression
- (2013) C. D. McFarland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
- (2013) H. Shi et al. Cancer Discovery
- Evolutionary dynamics of cancer in response to targeted combination therapy
- (2013) Ivana Bozic et al. eLife
- Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor
- (2012) Xun Xu et al. CELL
- EMT and Dissemination Precede Pancreatic Tumor Formation
- (2012) Andrew D. Rhim et al. CELL
- The Life History of 21 Breast Cancers
- (2012) Serena Nik-Zainal et al. CELL
- Modelling the evolution of genetic instability during tumour progression
- (2012) Ruchira S. Datta et al. Evolutionary Applications
- Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
- (2012) Sandra Misale et al. NATURE
- The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
- (2012) Luis A. Diaz Jr et al. NATURE
- Chromosomal duplication is a transient evolutionary solution to stress
- (2012) A. H. Yona et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential
- (2012) N. L. Solimini et al. SCIENCE
- Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer
- (2011) R. Roylance et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer
- (2011) N. J. Birkbak et al. CANCER RESEARCH
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
- (2011) Philip J. Stephens et al. CELL
- Oligometastases revisited
- (2011) Ralph R. Weichselbaum et al. Nature Reviews Clinical Oncology
- The Birth-Death-Mutation Process: A New Paradigm for Fat Tailed Distributions
- (2011) Yosef E. Maruvka et al. PLoS One
- Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
- (2010) Rocio Sotillo et al. NATURE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Accumulation of driver and passenger mutations during tumor progression
- (2010) I. Bozic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutator phenotype in cancer: Origin and consequences
- (2010) Lawrence A. Loeb SEMINARS IN CANCER BIOLOGY
- Chromosomal instability determines taxane response
- (2009) C. Swanton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Near Neutrality
- (2008) Austin L. Hughes Annals of the New York Academy of Sciences
- Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis
- (2008) A Walther et al. GUT
- The Population Genetics of dN/dS
- (2008) Sergey Kryazhimskiy et al. PLoS Genetics
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More