Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution

Chromosomal instability and transcriptome dynamics in cancer

(2013) Joshua B. Stevens et al.   CANCER AND METASTASIS REVIEWS

Karyotype Heterogeneity and Unclassified Chromosomal Abnormalities

(2013) H.H.Q. Heng et al.   CYTOGENETIC AND GENOME RESEARCH

Preface

(2013) Henry H.Q. Heng   CYTOGENETIC AND GENOME RESEARCH

Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology

(2013) Steven D. Horne et al.   Systems Biology in Reproductive Medicine

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

Whole chromosome aneuploidy: Big mutations drive adaptation by phenotypic leap

(2012) Guangbo Chen et al.   BIOESSAYS

Genetic and Epigenetic Heterogeneity in Cancer: The Ultimate Challenge for Drug Therapy

(2012) H. H. Heng et al.   CURRENT DRUG TARGETS

Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells

(2012) Anna V. Roschke et al.   CURRENT DRUG TARGETS

Why imatinib remains an exception of cancer research

(2012) Steven D. Horne et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Aneuploidy as a mechanism for stress-induced liver adaptation

(2012) Andrew W. Duncan et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic analysis of a key innovation in an experimental Escherichia coli population

(2012) Zachary D. Blount et al.   NATURE

Perspective: Finding cancer's first principles

(2012) Robert Gatenby   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Evolution of the cancer genome

(2012) Lucy R. Yates et al.   NATURE REVIEWS GENETICS

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heterochromatin instability in cancer: From the Barr body to satellites and the nuclear periphery

(2012) Dawn M. Carone et al.   SEMINARS IN CANCER BIOLOGY

Time to Think Outside the (Genetic) Box

(2011) J.-P. J. Issa et al.   Cancer Prevention Research

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Is carcinogenesis a form of speciation?

(2011) Peter Duesberg et al.   CELL CYCLE

Decoding the genome beyond sequencing: The new phase of genomic research

(2011) Henry H.Q. Heng et al.   GENOMICS

The functional role of long non-coding RNA in human carcinomas

(2011) Ewan A Gibb et al.   Molecular Cancer

Non-coding RNAs in cancer initiation and progression and as novel biomarkers

(2011) S. Patrick Nana-Sinkam et al.   Molecular Oncology

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

(2011) Shanmuganathan Chandrakasan et al.   PEDIATRIC BLOOD & CANCER

The aneuploidy paradox: costs and benefits of an incorrect karyotype

(2011) Jason M. Sheltzer et al.   TRENDS IN GENETICS

Diverse system stresses: common mechanisms of chromosome fragmentation

(2011) J B Stevens et al.   Cell Death & Disease

Application of Biomarkers in Cancer Risk Management: Evaluation from Stochastic Clonal Evolutionary and Dynamic System Optimization Points of View

(2011) Xiaohong Li et al.   PLoS Computational Biology

The enemy within: An epigenetic role of retrotransposons in cancer initiation

(2010) Adam S. Wilkins   BIOESSAYS

SEX REDUCES GENETIC VARIATION: A MULTIDISCIPLINARY REVIEW

(2010) Root Gorelick et al.   EVOLUTION

Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer

(2010) Rebecca A. Burrell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

(2010) So Yeon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

From the editors

(2010)   NATURE REVIEWS GENETICS

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The genome-centric concept: resynthesis of evolutionary theory

(2009) Henry H. Q. Heng   BIOESSAYS

THE ANIMAL WITHIN: CARCINOGENESIS AND THE CLONAL EVOLUTION OF CANCER CELLS ARE SPECIATION EVENTS SENSU STRICTO

(2009) Mark D. Vincent   EVOLUTION

The Evolution of Meiosis From Mitosis

(2009) A. S. Wilkins et al.   GENETICS

The interrelations of micronuclei, chromosomal instability, and mutational activity in acute non-lymphocytic leukemia-A hypothesis

(2009) BENKT HÖGSTEDT et al.   HEREDITAS

Genetic and epigenetic heterogeneity in cancer: A genome-centric perspective

(2009) Henry H.Q. Heng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer

(2009) Christine J. Ye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Global view of bionetwork dynamics: adaptive landscape

(2009) Ping Ao   Journal of Genetics and Genomics

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective

(2009) Sui Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

(2009) Yuri B Yurov et al.   Molecular Cytogenetics

Psychologic intervention improves survival for breast cancer patients

(2008) Barbara L. Andersen et al.   CANCER

The Aneuploidy Paradox in Cell Growth and Tumorigenesis

(2008) Beth A. Weaver et al.   CANCER CELL

Genetic Instability Is Not a Requirement for Tumor Development

(2008) W. Bodmer et al.   CANCER RESEARCH

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis

(2008) William M. Grady et al.   GASTROENTEROLOGY

The Conflict Between Complex Systems and Reductionism

(2008) Henry H. Q. Heng   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Do stress-related psychosocial factors contribute to cancer incidence and survival?

(2008) Yoichi Chida et al.   Nature clinical practice. Oncology