Involvement of CD8+ T Cells in Multiple Sclerosis

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

(2015) Catherine Larochelle et al.   ANNALS OF NEUROLOGY

P-glycoprotein regulates trafficking of CD8+ T cells to the brain parenchyma

(2014) Gijs Kooij et al.   ACTA NEUROPATHOLOGICA

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM)

(2014) Pradeep K. Dagur et al.   CLINICAL IMMUNOLOGY

High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+T cells

(2014) Andreas Lossius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD8+MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis

(2014) Anne Willing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune regulation of multiple sclerosis by CD8+ T cells

(2014) Sushmita Sinha et al.   IMMUNOLOGIC RESEARCH

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

The IL-17A-Producing CD8 + T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multiple sclerosis genetics

(2014) Stephen Sawcer et al.   LANCET NEUROLOGY

Perforin Competent CD8 T Cells Are Sufficient to Cause Immune-Mediated Blood-Brain Barrier Disruption

(2014) Holly L. Johnson et al.   PLoS One

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis

(2013) Sofia V. Abrahamsson et al.   BRAIN

CD8+T cells in multiple sclerosis

(2013) Aleksandar Denic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis

(2013) Francesco Lolli et al.   Journal of Neuroinflammation

MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells

(2013) Qingyong Ji et al.   NATURE IMMUNOLOGY

Persistent Changes in Circulating and Intestinal γδ T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease

(2013) Margaret R. Dunne et al.   PLoS One

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

(2013) Hongxia Duan et al.   Scientific Reports

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

(2012) Catherine Larochelle et al.   BRAIN

Frequency of circulating autoreactive T cells committed to myelin determinants in relapsing–remitting multiple sclerosis patients

(2012) Annie Elong Ngono et al.   CLINICAL IMMUNOLOGY

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

(2012) Magdalena Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of the Paired TCR α- and β-chains of Single Human T Cells

(2012) Song-Min Kim et al.   PLoS One

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

(2012) Ken Flanagan et al.   PLoS One

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on  4 integrin

(2011) I. Ifergan et al.   BRAIN

CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis

(2011) Viviana Annibali et al.   BRAIN

Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis

(2011) Yusei Miyazaki et al.   INTERNATIONAL IMMUNOLOGY

Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse

(2011) H.H. Wang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Endogenous MHC-Related Protein 1 Is Transiently Expressed on the Plasma Membrane in a Conformation That Activates Mucosal-Associated Invariant T Cells

(2011) W.-J. Chua et al.   JOURNAL OF IMMUNOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Altered Development of NKT Cells, γδ T Cells, CD8 T Cells and NK Cells in a PLZF Deficient Patient

(2011) Maggie Eidson et al.   PLoS One

CD161-Expressing Human T Cells

(2011) Joannah R. Fergusson et al.   Frontiers in Immunology

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis?

(2010) C. Pierrot-Deseilligny et al.   BRAIN

Saliva-Derived DNA Performs Well in Large-Scale, High-Density Single-Nucleotide Polymorphism Microarray Studies

(2010) M. Bahlo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

(2010) Qingyong Ji et al.   NATURE IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Sclerosis: Association with HL-A3

(2010) S. NAITO et al.   TISSUE ANTIGENS

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

Collateral Bystander Damage by Myelin-Directed CD8+ T Cells Causes Axonal Loss

(2009) Bettina Sobottka et al.   AMERICAN JOURNAL OF PATHOLOGY

Antigen-Specific Blockade of Lethal CD8 T-Cell Mediated Autoimmunity in a Mouse Model of Multiple Sclerosis

(2009) Shin-Young Na et al.   JOURNAL OF IMMUNOLOGY

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

(2009) Gijs Kooij et al.   PLoS One

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

Naïve CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system

(2008) Shin-Young Na et al.   BRAIN

Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis

(2008) Xin Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF

(2008) C MALMESTROM et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY