Generation, maintenance and tissue distribution of T cell responses to human cytomegalovirus in lytic and latent infection

The (gradual) rise of memory inflation

(2018) Paul Klenerman   IMMUNOLOGICAL REVIEWS

TCR repertoire evolution during maintenance of CMV-specific T-cell populations

(2018) Kilian Schober et al.   IMMUNOLOGICAL REVIEWS

Cytomegalovirus: Shape-Shifting the Immune System

(2018) Gaëlle Picarda et al.   JOURNAL OF IMMUNOLOGY

Assigning Cytomegalovirus Status in Children Awaiting Organ Transplant: Viral Shedding, CMV-Specific T Cells, and CD27−CD28−CD4+ T Cells

(2018) Catherine E Burton et al.   JOURNAL OF INFECTIOUS DISEASES

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

(2018) Miri Shnayder et al.   mBio

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8 + T Cells by Persistent Viruses and Vaccines

(2018) Claire Louse Gordon et al.   Cell Reports

A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency

(2018) Emma L. Poole et al.   Cell Reports

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose

(2018) Anke Redeker et al.   Frontiers in Immunology

The impact of inflationary cytomegalovirus-specific memory T cells on anti-tumour immune responses in patients with cancer

(2018) Xiao-Hua Luo et al.   IMMUNOLOGY

CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death

(2018) Alejandra Pera et al.   Theranostics

Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

(2018) Kaitlyn M. Morabito et al.   Frontiers in Immunology

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

(2018) Paul Lindau et al.   JOURNAL OF IMMUNOLOGY

Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection

(2017) Claire L. Gordon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytomegalovirus (CMV) Epitope–Specific CD4+T Cells Are Inflated in HIV+CMV+Subjects

(2017) Chike O. Abana et al.   JOURNAL OF IMMUNOLOGY

Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

(2017) Lisa Borkner et al.   JOURNAL OF IMMUNOLOGY

CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival

(2017) Martha Bajwa et al.   JOURNAL OF INFECTIOUS DISEASES

Human Cytomegalovirus (HCMV)-Specific CD4 + T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro

(2017) Sarah E. Jackson et al.   JOURNAL OF VIROLOGY

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency

(2017) Shu Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection

(2017) Benjamin A. Krishna et al.   mBio

Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8+ T-Cell Repertoire in Older People

(2017) Louise Hosie et al.   Frontiers in Immunology

Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells

(2017) Sarah E. Jackson et al.   Frontiers in Immunology

CMV immune evasion and manipulation of the immune system with aging

(2017) Sarah E. Jackson et al.   GeroScience

Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review

(2016) Marlies Weltevrede et al.   EXPERIMENTAL GERONTOLOGY

CMV induces expansion of highly polyfunctional CD4 + T cell subset coexpressing CD57 and CD154

(2016) Alejandra Pera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency

(2016) Song Hee Lee et al.   JOURNAL OF VIROLOGY

Leukocyte Immunoglobulin-Like Receptor 1-Expressing Human Natural Killer Cell Subsets Differentially Recognize Isolates of Human Cytomegalovirus through the Viral Major Histocompatibility Complex Class I Homolog UL18

(2016) Kevin C. Chen et al.   JOURNAL OF VIROLOGY

Severe Symptomatic Primary Human Cytomegalovirus Infection despite Effective Innate and Adaptive Immune Responses

(2016) Raphaëlle Riou et al.   JOURNAL OF VIROLOGY

A new perspective of the structural complexity of HCMV-specific T-cell responses

(2016) Andrew Sylwester et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Impact of Persistent Cytomegalovirus Infection on Dynamic Changes in Human Immune System Profile

(2016) Rosanna Vescovini et al.   PLoS One

Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation

(2016) Joanne Trgovcich et al.   PLoS One

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs

(2016) Heng Giap Woon et al.   PLoS Pathogens

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

(2016) Iryna Dekhtiarenko et al.   PLoS Pathogens

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

(2016) Mathew Clement et al.   PLoS Pathogens

Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years

(2016) Helen M. Parry et al.   Immunity & Ageing

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance

(2016) Rafaela Holtappels et al.   Frontiers in Immunology

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Primary human cytomegalovirus infections: Kinetics of ELISA-IgG and neutralizing antibody in pauci/asymptomatic pregnant women vs symptomatic non-pregnant subjects

(2015) Chiara Fornara et al.   JOURNAL OF CLINICAL VIROLOGY

Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection

(2015) Shilpi Verma et al.   JOURNAL OF VIROLOGY

Sleepless latency of human cytomegalovirus

(2015) Emma Poole et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

Functional classification of memory CD8+ T cells by CX3CR1 expression

(2015) Jan P. Böttcher et al.   Nature Communications

Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)–Seropositive Individuals Are Sites of HCMV Reactivation In Vivo

(2015) Emma Poole et al.   JOURNAL OF INFECTIOUS DISEASES

The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?

(2014) Mark R Wills et al.   Cellular & Molecular Immunology

Cytomegalovirus drives Vδ2negγδ T cell inflation in many healthy virus carriers with increasing age

(2014) A. Alejenef et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response

(2014) Nils H Jost et al.   IMMUNOLOGY AND CELL BIOLOGY

Cutting Edge: Murine Cytomegalovirus Induces a Polyfunctional CD4 T Cell Response

(2014) R. Arens et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Latency-Associated Viral Interleukin-10 (IL-10) Encoded by Human Cytomegalovirus Modulates Cellular IL-10 and CCL8 Secretion during Latent Infection through Changes in the Cellular MicroRNA hsa-miR-92a

(2014) E. Poole et al.   JOURNAL OF VIROLOGY

Clonal Evolution of CD8+T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function

(2014) Ester B. M. Remmerswaal et al.   JOURNAL OF VIROLOGY

Diverse Specificities, Phenotypes, and Antiviral Activities of Cytomegalovirus-Specific CD8+ T Cells

(2014) S. E. Jackson et al.   JOURNAL OF VIROLOGY

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus

(2013) Rosanna Vescovini et al.   AGE

Competition between T cells maintains clonal dominance during memory inflation induced by MCMV

(2013) Holly Turula et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A New Model for CD8+ T Cell Memory Inflation Based upon a Recombinant Adenoviral Vector

(2013) B. Bolinger et al.   JOURNAL OF IMMUNOLOGY

A Novel Cytomegalovirus-Induced Regulatory-Type T-Cell Subset Increases in Size During Older Life and Links Virus-Specific Immunity to Vascular Pathology

(2013) Nadia Terrazzini et al.   JOURNAL OF INFECTIOUS DISEASES

Intensity of the Humoral Response to Cytomegalovirus Is Associated with the Phenotypic and Functional Status of the Immune System

(2013) R. Alonso Arias et al.   JOURNAL OF VIROLOGY

Cytomegalovirus (CMV) seroprevalence in Japanese blood donors and high detection frequency of CMV DNA in elderly donors

(2013) Yasumi Furui et al.   TRANSFUSION

Human Cytomegalovirus Latency-Associated Proteins Elicit Immune-Suppressive IL-10 Producing CD4+ T Cells

(2013) Gavin M. Mason et al.   PLoS Pathogens

Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function

(2012) G. M. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

(2012) P. L. Klarenbeek et al.   PLoS Pathogens

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age

(2012) Alina Lelic et al.   PLoS Pathogens

Cytomegalovirus-Specific Regulatory and Effector T Cells Share TCR Clonality-Possible Relation to Repetitive CMV Infections

(2011) S. Schwele et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes

(2011) E. B. M. Remmerswaal et al.   BLOOD

Polyfunctional T Cells Accumulate in Large Human Cytomegalovirus-Specific T Cell Responses

(2011) R. Lachmann et al.   JOURNAL OF VIROLOGY

Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

(2010) Kirsten M.L. Hertoghs et al.   JOURNAL OF CLINICAL INVESTIGATION

Intense Antiextracellular Adaptive Immune Response to Human Cytomegalovirus in Very Old Subjects with Impaired Health and Cognitive and Functional Status

(2010) R. Vescovini et al.   JOURNAL OF IMMUNOLOGY

Human cytomegalovirus immunity and immune evasion

(2010) Sarah E. Jackson et al.   VIRUS RESEARCH

Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals

(2009) S. Chidrawar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

(2009) T. Crough et al.   CLINICAL MICROBIOLOGY REVIEWS

Analysis of latent viral gene expression in natural and experimental latency models of human cytomegalovirus and its correlation with histone modifications at a latent promoter

(2009) M. B. Reeves et al.   JOURNAL OF GENERAL VIROLOGY

Clonotype Selection and Composition of Human CD8 T Cells Specific for Persistent Herpes Viruses Varies with Differentiation but Is Stable Over Time

(2009) E. M. Iancu et al.   JOURNAL OF IMMUNOLOGY

Regulatory function of cytomegalovirus-specific CD4+CD27−CD28− T cells

(2009) Adriana Tovar-Salazar et al.   VIROLOGY

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

(2009) María Pita-Lopez et al.   Immunity & Ageing

Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

(2008) U. Palendira et al.   BLOOD

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

(2008) Christopher M. Snyder et al.   IMMUNITY

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

(2008) Angelika Schwanninger et al.   Immunity & Ageing

A fingerprint left by cytomegalovirus infection in the human T cell compartment

(2007) Pablo J.E.J. van de Berg et al.   JOURNAL OF CLINICAL VIROLOGY