The (gradual) rise of memory inflation

Chimpanzee adenoviral vectors as vaccines – challenges to move the technology into the fast lane

(2017) Alessandra Vitelli et al.   Expert Review of Vaccines

Differentiation and Protective Capacity of Virus-Specific CD8 + T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche

(2017) Vesselin T. Tomov et al.   IMMUNITY

Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia

(2017) Stephen B. Kennedy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell transcriptomics to explore the immune system in health and disease

(2017) Michael J. T. Stubbington et al.   SCIENCE

Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

(2017) Katie Ewer et al.   Human Vaccines & Immunotherapeutics

Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order

(2017) Lian N. Lee et al.   PLoS Pathogens

Recent advances in CMV tropism, latency, and diagnosis during aging

(2017) Sean X. Leng et al.   GeroScience

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Development of replication-deficient adenovirus malaria vaccines

(2016) Michael R. Hollingdale et al.   Expert Review of Vaccines

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Modification of Antigen Impacts on Memory Quality after Adenovirus Vaccination

(2016) Julia M. Colston et al.   JOURNAL OF IMMUNOLOGY

Immediate Dysfunction of Vaccine-Elicited CD8+T Cells Primed in the Absence of CD4+T Cells

(2016) Nicholas M. Provine et al.   JOURNAL OF IMMUNOLOGY

A new perspective of the structural complexity of HCMV-specific T-cell responses

(2016) Andrew Sylwester et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation

(2016) Joanne Trgovcich et al.   PLoS One

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

(2016) Iryna Dekhtiarenko et al.   PLoS Pathogens

Multifunctional cytomegalovirus (CMV)-specific CD8+T cells are not restricted by telomere-related senescence in young or old adults

(2015) Natalie E. Riddell et al.   IMMUNOLOGY

Memory T Cells Specific for Murine Cytomegalovirus Re-Emerge after Multiple Challenges and Recapitulate Immunity in Various Adoptive Transfer Scenarios

(2015) Michael Quinn et al.   JOURNAL OF IMMUNOLOGY

The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+T Cells

(2015) Anke Redeker et al.   JOURNAL OF IMMUNOLOGY

Chimpanzee adenovirus– and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

(2015) Christopher A. Green et al.   Science Translational Medicine

Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections

(2015) Geraldine Taylor et al.   Science Translational Medicine

Functional classification of memory CD8+ T cells by CX3CR1 expression

(2015) Jan P. Böttcher et al.   Nature Communications

The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

(2015) Suzanne PM Welten et al.   eLife

Cytomegalovirus Infection and Memory T Cell Inflation

(2015) Jihye Kim et al.   Immune Network

A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells

(2014) E. Lopez-Granados et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells

(2014) Stuart Sims et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells

(2014) A. van Stijn et al.   JOURNAL OF IMMUNOLOGY

CD73 Is Dispensable for the Regulation of Inflationary CD8+ T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation

(2014) Stuart Sims et al.   PLoS One

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

(2014) L. Swadling et al.   Science Translational Medicine

Systemic Hematogenous Maintenance of Memory Inflation by MCMV Infection

(2014) Corinne J. Smith et al.   PLoS Pathogens

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Seropositivity and Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Mortality in the Population-Based European Prospective Investigation of Cancer–Norfolk Cohort

(2013) Effrossyni Gkrania-Klotsas et al.   CLINICAL INFECTIOUS DISEASES

Viral inoculum dose impacts memory T-cell inflation

(2013) Anke Redeker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Competition for Antigen at the Level of the APC Is a Major Determinant of Immunodominance during Memory Inflation in Murine Cytomegalovirus Infection

(2013) L. A. Farrington et al.   JOURNAL OF IMMUNOLOGY

Priming of CD8+ T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation

(2013) A. Busche et al.   JOURNAL OF IMMUNOLOGY

A New Model for CD8+ T Cell Memory Inflation Based upon a Recombinant Adenoviral Vector

(2013) B. Bolinger et al.   JOURNAL OF IMMUNOLOGY

Evolution of CD8+ T Cell Responses after Acute PARV4 Infection

(2013) R. Simmons et al.   JOURNAL OF VIROLOGY

CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus Infection

(2013) S. P. M. Welten et al.   JOURNAL OF VIROLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

A novel method for autophagy detection in primary cells

(2012) Kanchan Phadwal et al.   Autophagy

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Incident Ischemic Heart Disease in the Population-Based EPIC-Norfolk Cohort

(2012) E. Gkrania-Klotsas et al.   JOURNAL OF INFECTIOUS DISEASES

Viral latency drives ‘memory inflation’: a unifying hypothesis linking two hallmarks of cytomegalovirus infection

(2012) Christof K. Seckert et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species

(2012) S. Colloca et al.   Science Translational Medicine

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

(2012) E. Barnes et al.   Science Translational Medicine

Memory T cell inflation: understanding cause and effect

(2012) Geraldine A. O’Hara et al.   TRENDS IN IMMUNOLOGY

Batf3 transcription factor-dependent DC subsets in murine CMV infection: Differential impact on T-cell priming and memory inflation

(2011) Nicole Torti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell help permits memory CD8+ T-cell inflation during cytomegalovirus latency

(2011) Senta M. Walton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency

(2011) C. K. Seckert et al.   JOURNAL OF GENERAL VIROLOGY

Differential B7–CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-Specific Memory CD8 T Cell Populations

(2011) Ramon Arens et al.   JOURNAL OF IMMUNOLOGY

High Frequency, Sustained T Cell Responses to PARV4 Suggest Viral Persistence In Vivo

(2011) Ruth Simmons et al.   JOURNAL OF INFECTIOUS DISEASES

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

A Dominant Role for the Immunoproteasome in CD8+ T Cell Responses to Murine Cytomegalovirus

(2011) Sarah Hutchinson et al.   PLoS One

Sustained CD8+ T Cell Memory Inflation after Infection with a Single-Cycle Cytomegalovirus

(2011) Christopher M. Snyder et al.   PLoS Pathogens

Non-Hematopoietic Cells in Lymph Nodes Drive Memory CD8 T Cell Inflation during Murine Cytomegalovirus Infection

(2011) Nicole Torti et al.   PLoS Pathogens

CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells

(2010) J. D. Bassett et al.   BLOOD

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells

(2010) Ian R. Humphreys et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Persistence of Transgene Expression Influences CD8+ T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus

(2009) J. D. Finn et al.   JOURNAL OF VIROLOGY

CMV and the Art of Memory Maintenance

(2008) Paul Klenerman et al.   IMMUNITY

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

(2008) Christopher M. Snyder et al.   IMMUNITY

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

(2008) Surojit Sarkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamics of T cell memory in human cytomegalovirus infection

(2008) Edward C. P. Waller et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE