λ-Carrageenan Oligosaccharides of Distinct Anti-Heparanase and Anticoagulant Activities Inhibit MDA-MB-231 Breast Cancer Cell Migration

Targeting the microenvironment in solid tumors

(2018) Carmen Belli et al.   CANCER TREATMENT REVIEWS

Carrageenan: a review

(2018) J. Necas et al.   VETERINARNI MEDICINA

Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells

(2018) Jan Ponert et al.   MOLECULES

A review on synthesis, properties and applications of natural polymer based carrageenan blends and composites

(2017) Khalid Mahmood Zia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent

(2017) Nicolas Poupard et al.   Marine Drugs

Bioengineered heparins and heparan sulfates

(2016) Li Fu et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent advances in the discovery of heparanase inhibitors as anti-cancer agents

(2016) Li Jia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases

(2016) Silvia Rivara et al.   Future Medicinal Chemistry

Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase

(2016) Daniele Pala et al.   GLYCOBIOLOGY

MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin−/dermatan sulfate and hyaluronan biosynthesis

(2016) Manuela Viola et al.   GLYCOCONJUGATE JOURNAL

Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides

(2016) Minghong Ni et al.   MOLECULES

The US regulatory and pharmacopeia response to the global heparin contamination crisis

(2016) Anita Y Szajek et al.   NATURE BIOTECHNOLOGY

Heparanase and cancer progression: New directions, new promises

(2016) Gil Arvatz et al.   Human Vaccines & Immunotherapeutics

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Modulation of the binding of basic fibroblast growth factor and heparanase activity by purified λ-carrageenan oligosaccharides

(2015) Ting-Ting Niu et al.   CARBOHYDRATE POLYMERS

Structural characterization and antioxidant activities of κ-carrageenan oligosaccharides degraded by different methods

(2015) Yujiao Sun et al.   FOOD CHEMISTRY

Marine Polysaccharides from Algae with Potential Biomedical Applications

(2015) Maria de Jesus Raposo et al.   Marine Drugs

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy

(2015) Min Luo et al.   Scientific Reports

Heparanase as a Target in Cancer Therapy

(2014) Valentina Masola et al.   CURRENT CANCER DRUG TARGETS

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

(2014) Sucharita Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heparanase multiple effects in cancer

(2014) Yona Nadir et al.   THROMBOSIS RESEARCH

Structural features of glycol-split low-molecular-weight heparins and their heparin lyase generated fragments

(2013) Anna Alekseeva et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effects of sulfate group in red seaweed polysaccharides on anticoagulant activity and cytotoxicity

(2013) Wanai Liang et al.   CARBOHYDRATE POLYMERS

Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase

(2013) YANG LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Influence of red algal sulfated polysaccharides on blood coagulation and platelets activationin vitro

(2013) Ekaterina V. Sokolova et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Selective sulfation of carrageenans and the influence of sulfate regiochemistry on anticoagulant properties

(2012) Cristiano A. de Araújo et al.   CARBOHYDRATE POLYMERS

Anticoagulant Activity of a Unique Sulfated Pyranosic (1→3)-β-l-Arabinan through Direct Interaction with Thrombin

(2012) Paula V. Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Low molecular weight heparin suppresses tissue factor-mediated cancer cell invasion and migration in vitro

(2011) CAMILLE ETTELAIE et al.   Experimental and Therapeutic Medicine

Overview of Anticoagulant Activity of Sulfated Polysaccharides from Seaweeds in Relation to their Structures, Focusing on those of Green Seaweeds

(2010) M. Ciancia et al.   CURRENT MEDICINAL CHEMISTRY

Carrageenans: Biological properties, chemical modifications and structural analysis – A review

(2009) Vanessa Leiria Campo et al.   CARBOHYDRATE POLYMERS

The Tainted Heparin Story: An Update

(2009) Marco Guerrini et al.   THROMBOSIS AND HAEMOSTASIS