Article
Biochemistry & Molecular Biology
Joon Seok Lee, Hyun Geun Cho, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Seok-Jong Lee, Jongmin Lee, Sang Yub Lee, Seung Huh, Ji Yoon Kim, Ho Yun Chung
Summary: This study analyzed the effects of hypoxia on angiogenesis in arteriovenous malformation (AVM) patients and normal tissues. The results showed that AVM ECs exhibited higher angiogenesis capacity and expression of angiogenesis-related genes under hypoxic conditions. These findings provide a foundation for the development of AVM treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chanez Manseur, Hugo Groult, Manon Porta, Pierre-Edouard Bodet, Rachida Mersni-Achour, Raphaelle Petit, Samir Ali-Moussa, Benjamin Musnier, Didier Le Cerf, Tony Varacavoudin, Oualid Haddad, Angela Sutton, Cintia Emi Yanaguibashi Leal, Edilson Beserra Alencar-Filho, Jean-Marie Piot, Nicolas Bridiau, Thierry Maugard, Ingrid Fruitier-Arnaudin
Summary: Oligosaccharides derived from ?-carrageenan (?-COs) have shown promise in regulating heparanase activity and have potential therapeutic applications in cancer treatment. Commercial ?-carrageenan is a mixture of different CAR families and its composition does not reflect the real composition, limiting its clinical use. By comparing six commercial ?-CARs and applying H2O2-assisted depolymerization, ?-CO formulations with similar molar masses and sulfation degrees to those suitable for antitumor properties were obtained. However, the anti-HPSE activity of these new ?-COs was affected by other features, such as differences in the initial mixture composition and degradation induced by H2O2-based hydrolysis.
Article
Biochemical Research Methods
Mohit Chhabra, Norbert Wimmer, Qi Qi He, Vito Ferro
Summary: PG545 is a highly potent inhibitor of angiogenesis, tumor growth, metastasis, and various HS-dependent viruses, including SARS-CoV-2. New efficient routes for the synthesis of PG545 and analogues have been developed to address low yield and poor selectivity issues in the reported synthesis, with particular focus on improving the key glycosylation step.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Remi Cousin, Hugo Groult, Chanez Manseur, Romain Ferru-Clement, Mario Gani, Rachel Havret, Claire Toucheteau, Gregoire Prunier, Beatrice Colin, Franck Morel, Jean-Marie Piot, Isabelle Lanneluc, Kevin Baranger, Thierry Maugard, Ingrid Fruitier-Arnaudin
Summary: This study investigated the effects of a marine-derived lambda-carrageenan oligosaccharide on breast cancer cells, finding that it effectively reduced cell migration and invasion in an HPSE-dependent manner. Additionally, lambda-CO tightly controlled a HPSE/MMP-14/MMP-2 axis, leading to reduced MMP-2 activity.
Article
Cardiac & Cardiovascular Systems
Arne Schmidt, Maximilian Fuchs, Stevan D. Stojanovic, Chunguang Liang, Kevin Schmidt, Mira Jung, Ke Xiao, Jan Weusthoff, Annette Just, Angelika Pfanne, Jorg H. W. Distler, Thomas Dandekar, Jan Fiedler, Thomas Thum, Meik Kunz
Summary: In this study, a targeted bioinformatics approach was used to identify and validate transcription factors that regulate angiogenic signaling. The results revealed the role of KLF5 and SP1 in hypoxia sensing and inflammatory signaling, providing insights for potential therapeutic strategies in vascularization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Bicai Tang, Wenjuan Ma, Yunfeng Lin
Summary: Studies have shown the potential of nanomaterials in inhibiting pathological angiogenesis, providing new options for cancer treatment. Compared to traditional anti-angiogenic agents, nanomaterials have better targeting capabilities and therapeutic outcomes, reducing side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nutrition & Dietetics
Merwan Barkallah, Judith Nzoughet-Kouassi, Gilles Simard, Loric Thoulouze, Sebastien Marze, Marie-Helene Ropers, Ramaroson Andriantsitohaina
Summary: This study demonstrated that encapsulating delphinidin in sEVs significantly enhances its inhibitory effects on angiogenesis, increasing potency for endothelial proliferation, NO production, and capillary-like formation. Therefore, sEV-loaded delphinidin may be a promising approach for treating angiogenesis-related diseases.
Review
Biochemistry & Molecular Biology
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi
Summary: Angiogenesis is a complex process regulated by various molecules and plays a crucial role in tumor growth and metastasis. Targeted therapeutic research based on these molecules has led to the emergence of promising anti-angiogenic strategies in cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Paula V. Subirada, Maria V. Vaglienti, Mariana B. Joray, Maria C. Paz, Pablo F. Barcelona, Maria C. Sanchez
Summary: This study investigated the changes in autophagy flux during hypoxia and hypoxia-reoxygenation, as well as the effects of Rapamycin and Resveratrol on the gliotic and pro-angiogenic response of Muller glial cells (MGCs) under hypoxic conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hsiao-Yang Hsi, Shih-Wei Wang, Chia-Hsiung Cheng, Ka-Lai Pang, Jyh-Yih Leu, Szu-Hsing Chang, Yen-Tung Lee, Yueh-Hsiung Kuo, Chia-Ying Huang, Tzong-Huei Lee
Summary: In this study, a fungal strain Penicillium sumatraense SC29 isolated from the marine brown alga Sargassum cristaefolium was identified, and six compounds were isolated from its liquid fermented products. Among them, penisterine D (4) showed anti-angiogenic activity without cytotoxic effects. This makes it a promising candidate for further preclinical investigation.
Article
Cell Biology
Amanda M. Peluzzo, Michael V. Autieri
Summary: Angiogenesis is a vital process for development, wound repair, and tissue perfusion. Inflammation and neovascularization are interconnected biological processes. Although pro-inflammatory factors drive angiogenesis, the role of anti-inflammatory interleukins in this process remains unclear.
Article
Microbiology
Phuong M. Tran, Sharon S. Tang, Wilmara Salgado-Pabon
Summary: Staphylococcus aureus beta-toxin exacerbates invasive infections by interfering with tissue re-vascularization and vascular repair, highlighting its role as an anti-angiogenic virulence factor.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guenaelle Levallet, Fatemeh Dubois, Arthur Leclerc, Edwige Petit, Lien Bekaert, Maxime Faisant, Christian Creveuil, Evelyne Emery, Gerard Zalcman, Emmanuele Lechapt-Zalcman
Summary: This study demonstrates that changes in miRNA expression related to angiogenesis and hypoxia occur in patients with diffuse gliomas, and these miRNAs are correlated with histology/grade of gliomas and predict patient survival and progression-free survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Judy R. van Beijnum, Elisabeth J. M. Huijbers, Karlijn van Loon, Athanasios Blanas, Parvin Akbari, Arno Roos, Tse J. Wong, Stepan S. Denisov, Tilman M. Hackeng, Connie R. Jimenez, Patrycja Nowak-Sliwinska, Arjan W. Griffioen
Summary: Anti-angiogenic cancer therapies have immune-stimulatory properties. This study found that tumor endothelial cells overexpress and secrete the protein vimentin, which promotes angiogenesis and inhibits leukocyte-endothelial interactions. Targeting extracellular vimentin shows inhibition of angiogenesis and tumor growth, and induces a pro-inflammatory condition in the tumor.
NATURE COMMUNICATIONS
(2022)
Article
Ophthalmology
Vinicius Kniggendorf, Maria Eduarda Perrud Souza, Thatiane Russo, Marcelo Andrade de Lima, Alex Treiger Grupenmacher, Caio Regatieri, Juliana L. Dreyfuss
Summary: This study demonstrates the anti-angiogenic effect of mHep N-DRN through in vitro and in vivo experiments. It inhibits cell proliferation, tube formation, and migration without cytotoxicity or anticoagulant action. These findings suggest that mHep N-DRN may be a potential candidate for treating choroidal neovascularization.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anne-Claire Lagree, Fabienne Fasani, Clotilde Rouxel, Marine Pivet, Marie Pourcelot, Aurore Fablet, Aurore Romey, Gregory Caignard, Damien Vitour, Sandra Blaise-Boisseau, Claudine Kieda, Henri-Jean Boulouis, Nadia Haddad, Catherine Grillon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Chemistry, Medicinal
Heitor Gomes de Araujo-Filho, Jucilene F. dos Santos, Mikaella T. B. Carvalho, Laurent Picot, Ingrid Fruitier-Arnaudin, Hugo Groult, Lucindo J. Quintans-Junior, Jullyana S. S. Quintans
Summary: Limonene (LIM), a monoterpene abundant in Citrus fruits peels, has shown potential as a natural anticancer compound by inhibiting tumor initiation, growth, and angiogenesis, as well as inducing cancer cells apoptosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Marine Dupuit, Vivien Chavanelle, Benoit Chassaing, Fanny Perriere, Monique Etienne, Claire Plissonneau, Audrey Boscaro, Nicolas Barnich, Vincent Pialoux, Thierry Maugard, Florian Le Joubioux, Sebastien Peltier, Pascal Sirvent, Yolanda F. Otero, Nathalie Boisseau
Summary: The combination of high-intensity interval training (HIIT) and TOTUM-63 has shown to limit weight gain, improve glycemic control, increase colon mucosa microbiota diversity, and enhance the relative abundance of beneficial bacteria. These results suggest that this combination could be effective for managing obesity and prediabetes.
Article
Chemistry, Medicinal
Remi Cousin, Hugo Groult, Chanez Manseur, Romain Ferru-Clement, Mario Gani, Rachel Havret, Claire Toucheteau, Gregoire Prunier, Beatrice Colin, Franck Morel, Jean-Marie Piot, Isabelle Lanneluc, Kevin Baranger, Thierry Maugard, Ingrid Fruitier-Arnaudin
Summary: This study investigated the effects of a marine-derived lambda-carrageenan oligosaccharide on breast cancer cells, finding that it effectively reduced cell migration and invasion in an HPSE-dependent manner. Additionally, lambda-CO tightly controlled a HPSE/MMP-14/MMP-2 axis, leading to reduced MMP-2 activity.
Article
Materials Science, Biomaterials
Susana Carregal-Romero, Hugo Groult, Olga Canadas, Noelia A-Gonzalez, Ana Victoria Lechuga-Vieco, Belen Garcia-Fojeda, Fernando Herranz, Juan Pellico, Andres Hidalgo, Cristina Casals, Jesus Ruiz-Cabello
Summary: The coating composition of nanomedicines plays an important role in determining the fate and clearance of the medicines in the body. In this study, two micellar superparamagnetic iron oxide nanoparticles (SPION) with different coatings were compared to understand their impact in pulmonary administration. The results showed that phosphatidylcholine (PC) coating could prolong the retention time of the nanoparticles in the lungs, making it suitable for pulmonary drug delivery. On the other hand, bovine serum albumin (BSA) coated nanoparticles were cleared more rapidly.
BIOMATERIALS ADVANCES
(2022)
Article
Microbiology
Camille Maziere, Helene Agogue, Cristiana Cravo-Laureau, Christine Cagnon, Isabelle Lanneluc, Sophie Sable, Ingrid Fruitier-Arnaudin, Christine Dupuy, Robert Duran
Summary: The study revealed that microbial mats from exploited and abandoned salterns exhibit different bacterial and meiofaunal diversity, with higher salinity in exploited sites leading to lower bacterial diversity but higher eukaryotic diversity. The presence of certain bacterial and eukaryotic groups in the mats may be attributed to human actions such as salt recovery practices in exploited salterns.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Raimundo Gonsalves de Oliveira-Junior, Christiane Adrielly Alves Ferraz, Ana Paula de Oliveira, Edigenia Cavalcante da Cruz Araujo, Gregoire Prunier, Laureen Beaugeard, Hugo Groult, Laurent Picot, Edilson Beserra de Alencar Filho, Noureddine El Aouad, Larissa Araujo Rolim, Jackson Roberto Guedes da Silva Almeida
Summary: The study found that phyllacanthone (PHY) from Cnidoscolus quercifolius has the potential to inhibit melanoma by inhibiting cell migration and inducing apoptosis and cell cycle arrest.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Susana Carregal-Romero, Ana Beatriz Miguel-Coello, Lydia Martinez-Parra, Yolanda Marti-Mateo, Pablo Hernansanz-Agustin, Yilian Fernandez-Afonso, Sandra Plaza-Garcia, Lucia Gutierrez, Maria del Mar Munoz-Hernandez, Juliana Carrillo-Romero, Marina Pinol-Cancer, Pierre Lecante, Zurine Blasco-Iturri, Lucia Fadon, Ana C. Almansa-Garcia, Marco Moller, Dorleta Otaegui, Jose Antonio Enriquez, Hugo Groult, Jesus Ruiz-Cabello
Summary: Manganese ferrite nanoparticles have unique properties in bioimaging and catalytic therapies. They have been used as contrast agents in magnetic resonance imaging (MRI) and as catalase-mimicking nanozymes for hypoxia alleviation. A cost-efficient synthetic microwave method has been developed to manufacture ultrasmall manganese ferrite nanoparticles with enhanced bioimaging and catalytic properties. These nanoparticles can be used as multimodal contrast agents in MRI and positron emission tomography (PET), and also have improved catalytic efficiency.
Article
Chemistry, Medicinal
Jennifer Saliba, Chanez Manseur, Hugo Groult, Hussein Akil, Mona Tannoury, Danielle Troutaud, Thierry Maugard, Jean Feuillard, Ingrid Arnaudin, Chantal Jayat-Vignoles
Summary: EBV infection is widespread and can lead to lymphomas. Both LCLs and DLBCLs cells overexpressing PD-L1 can inhibit T-cell response. Fucoidan, extracted from brown seaweed, shows potential for reducing PD-L1 expression and improving treatment of lymphoma cells. This finding has implications for immunotherapy.
Article
Chemistry, Medicinal
Chanez Manseur, Hugo Groult, Manon Porta, Pierre-Edouard Bodet, Rachida Mersni-Achour, Raphaelle Petit, Samir Ali-Moussa, Benjamin Musnier, Didier Le Cerf, Tony Varacavoudin, Oualid Haddad, Angela Sutton, Cintia Emi Yanaguibashi Leal, Edilson Beserra Alencar-Filho, Jean-Marie Piot, Nicolas Bridiau, Thierry Maugard, Ingrid Fruitier-Arnaudin
Summary: Oligosaccharides derived from ?-carrageenan (?-COs) have shown promise in regulating heparanase activity and have potential therapeutic applications in cancer treatment. Commercial ?-carrageenan is a mixture of different CAR families and its composition does not reflect the real composition, limiting its clinical use. By comparing six commercial ?-CARs and applying H2O2-assisted depolymerization, ?-CO formulations with similar molar masses and sulfation degrees to those suitable for antitumor properties were obtained. However, the anti-HPSE activity of these new ?-COs was affected by other features, such as differences in the initial mixture composition and degradation induced by H2O2-based hydrolysis.
Article
Chemistry, Multidisciplinary
Hugo Groult, Susana Carregal-Romero, David Castejon, Mikel Azkargorta, Ana-Beatriz Miguel-Coello, Krishna Reddy Pulagam, Vanessa Gomez-Vallejo, Remi Cousin, Maria Munoz-Caffarel, Charles H. Lawrie, Jordi Llop, Jean-Marie Piot, Felix Elortza, Thierry Maugard, Jesus Ruiz-Cabello, Ingrid Fruitier-Arnaudin
Summary: This study successfully prepared HEP-ESIONP probes with excellent MRI contrast using a one-pot microwave method with heparin oligosaccharides (HO) of different lengths as coatings, demonstrating anticoagulant properties and/or specific antitumor activity based on the length of HO used. In vivo distribution study showed significant changes in probe behaviors and renal clearance with shortening of HO length, while in vitro characterization of protein coronas provided insight into the crucial impact of HO length on opsonization-mediated immune response and elimination. The precise HO length identified in this study resulted in ESIONP probes with prolonged vascular lifetime, moderate tumor accumulation, low uptake by non-specific organs, and favorable urinary clearance, meeting prerequisites for advanced theranostic medical applications with dual MRI/PET hot spot capability and potential antitumor activity.