Cancer immunogenicity, danger signals, and DAMPs: What, when, and how?

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Inducers of immunogenic cancer cell death

(2013) Aleksandra M. Dudek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

(2013) Deborah A. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

Autophagy: shaping the tumor microenvironment and therapeutic response

(2013) Hannelore Maes et al.   TRENDS IN MOLECULAR MEDICINE

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40

(2012) Y. Yang et al.   BLOOD

Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

(2012) Hui-Ming Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

(2012) S. Miyamoto et al.   CANCER RESEARCH

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

(2012) Yoshiyuki Suzuki et al.   CANCER RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

A molecular view on signal transduction by the apoptosome

(2012) Thomas F. Reubold et al.   CELLULAR SIGNALLING

Enlightening the impact of immunogenic cell death in photodynamic cancer therapy

(2012) Lorenzo Galluzzi et al.   EMBO JOURNAL

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Wogonin Induces Reactive Oxygen Species Production and Cell Apoptosis in Human Glioma Cancer Cells

(2012) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro Studies on Erythrosine-Based Photodynamic Therapy of Malignant and Pre-Malignant Oral Epithelial Cells

(2012) Abhishek D. Garg et al.   PLoS One

Wogonin Induced Calreticulin/Annexin A1 Exposure Dictates the Immunogenicity of Cancer Cells in a PERK/AKT Dependent Manner

(2012) Yong Yang et al.   PLoS One

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Primary sterile necrotic cells fail to cross-prime CD8+T cells

(2012) Jaba Gamrekelashvili et al.   OncoImmunology

The emergence of phox-ER stress induced immunogenic apoptosis

(2012) Abhishek D. Garg et al.   OncoImmunology

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Strategies to counteract MHC-I defects in tumors

(2011) Margit H Lampen et al.   CURRENT OPINION IN IMMUNOLOGY

Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody

(2011) Greta Garrido et al.   JOURNAL OF IMMUNOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

(2011) Vinod P Balachandran et al.   NATURE MEDICINE

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

(2011) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment

(2011) Stefan Stangl et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

Cytosolic surveillance and antiviral immunity

(2011) Vijay AK Rathinam et al.   Current Opinion in Virology

Induction and function of type I and III interferon in response to viral infection

(2011) David E Levy et al.   Current Opinion in Virology

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

(2010) Abhishek D. Garg et al.   APOPTOSIS

Extracellular heat shock protein HSP90β secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-β1

(2010) Shigeki Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

Decoding Cell Death Signals in Inflammation and Immunity

(2010) Laurence Zitvogel et al.   CELL

Chemotherapy induces ATP release from tumor cells

(2010) Isabelle Martins et al.   CELL CYCLE

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

(2010) Liliana Schaefer   CURRENT OPINION IN PHARMACOLOGY

Higher levels of GATA3 predict better survival in women with breast cancer

(2010) Nam K. Yoon et al.   HUMAN PATHOLOGY

Immune evasion of microsatellite unstable colorectal cancers

(2010) Matthias Kloor et al.   INTERNATIONAL JOURNAL OF CANCER

From procaspase-8 to caspase-8: Revisiting structural functions of caspase-8

(2010) Yang Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcriptional Regulation of the Endogenous Danger Signal Tenascin-C: A Novel Autocrine Loop in Inflammation

(2010) Fui G. Goh et al.   JOURNAL OF IMMUNOLOGY

Cancer and Inflammation: Promise for Biologic Therapy

(2010) Sandra Demaria et al.   JOURNAL OF IMMUNOTHERAPY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

The Mitochondrion — A Trojan Horse That Kicks Off Inflammation?

(2010) Angelo A. Manfredi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular BCL2 Proteins Are Danger-Associated Molecular Patterns That Reduce Tissue Damage in Murine Models of Ischemia-Reperfusion Injury

(2010) Akiko Iwata et al.   PLoS One

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Antigenic profiles of individual-matched pairs of primary and melanoma metastases

(2009) Clifton B. Meije et al.   HUMAN PATHOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

(2009) Yang Liu et al.   TRENDS IN IMMUNOLOGY

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy

(2008) C Tosch et al.   CANCER GENE THERAPY

Caspase-8 in cancer biology and therapy

(2008) Simone Fulda   CANCER LETTERS

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

(2008) T Panaretakis et al.   CELL DEATH AND DIFFERENTIATION

Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma

(2008) A. Tzankov et al.   HAEMATOLOGICA

Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma

(2008) Sabine Schreck et al.   HEMATOLOGICAL ONCOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

Exosomes as a tumor immune escape mechanism: possible therapeutic implications

(2008) Thomas E Ichim et al.   Journal of Translational Medicine

Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity

(2008) Davide Brusa et al.   VACCINE