Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice

Ischemic Preconditioning protects hepatocytes from ischemia-reperfusion injury via TGR5-mediated anti-apoptosis

(2016) Lin Zhuang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RP105 protects against myocardial ischemia–reperfusion injury via suppressing TLR4 signaling pathways in rat model

(2016) Xinxin Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2/MAPK signaling pathway in glomerular mesangial cells

(2016) Zhiying Yang et al.   EXPERIMENTAL CELL RESEARCH

Cardioprotective effect of miRNA-22 on hypoxia/reoxygenation induced cardiomyocyte injury in neonatal rats

(2016) Jian Yang et al.   GENE

Ozone oxidative preconditioning protects the rat kidney from reperfusion injury via modulation of the TLR4-NF-κB pathway

(2015) Bianzhi Xing et al.   Acta Cirurgica Brasileira

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Ankaflavin ameliorates steatotic liver ischemia-reperfusion injury in mice

(2015) Hao-Jun Yang et al.   Hepatobiliary & Pancreatic Diseases International

Bile acids: emerging role in management of liver diseases

(2015) Amon Asgharpour et al.   Hepatology International

Expression of Inflammatory and Regenerative Genes in a Model of Liver Ischemia/Reperfusion and Partial Hepatectomy

(2015) Panagiotis Athanasopoulos et al.   JOURNAL OF INVESTIGATIVE SURGERY

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Aberrant DNA Methylation of G-protein-coupled Bile Acid Receptor Gpbar1 (TGR5) is a Potential Biomarker for Hepatitis B Virus Associated Hepatocellular Carcinoma

(2014) Li-Yan Han et al.   International Journal of Medical Sciences

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

(2014) Alessia Perino et al.   JOURNAL OF CLINICAL INVESTIGATION

IRAK4 as a Molecular Target in the Amelioration of Innate Immunity–Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid

(2014) Sun Hong Park et al.   JOURNAL OF IMMUNOLOGY

G-Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype

(2014) Klemens Högenauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of the bile acid receptor TGR5 enhances LPS-induced inflammatory responses in a human monocytic cell line

(2014) Kaia Mobraten et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

(2014) Nuruddeen D. Lewis et al.   PLoS One

Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells

(2013) Taiki Kida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice

(2013) Gary W. Nace et al.   HEPATOLOGY

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells

(2013) Ying-li Qiao et al.   JOURNAL OF SURGICAL RESEARCH

Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation

(2012) Ivan Casaburi et al.   CELL CYCLE

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

(2012) Riko Ichikawa et al.   IMMUNOLOGY

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

TGR5 in the Biliary Tree

(2011) Verena Keitel et al.   DIGESTIVE DISEASES

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

All-trans Retinoic Acid Alleviates Hepatic Ischemia/Reperfusion Injury by Enhancing Manganese Superoxide Dismutase in Rats

(2010) Jianhua Rao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G Protein–Coupled Receptor Connectivity to NF-κB in Inflammation and Cancer

(2008) Christopher C. Fraser   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism

(2008) Charles Thomas et al.   THYROID