Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects

An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated gene editing

(2018) Yibo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

(2018) Almary Guerra et al.   eLife

Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly

(2017) Andrew DiStasio et al.   HUMAN MOLECULAR GENETICS

De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects

(2017) Anne Slavotinek et al.   HUMAN MOLECULAR GENETICS

Zebrafish Models of Human Disease: Gaining Insight into Human Disease at ZFIN

(2017) Yvonne M. Bradford et al.   ILAR JOURNAL

Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA

(2017) Xiquan Liang et al.   JOURNAL OF BIOTECHNOLOGY

The complex genetics of hypoplastic left heart syndrome

(2017) Xiaoqin Liu et al.   NATURE GENETICS

Estimating the selective effects of heterozygous protein-truncating variants from human exome data

(2017) Christopher A Cassa et al.   NATURE GENETICS

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

(2017) Sheng Chih Jin et al.   NATURE GENETICS

Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system

(2017) Yihan Zhang et al.   Nature Communications

Highly Efficient, Rapid and Co-CRISPR Independent Genome Editing in Caenorhabditis elegans

(2017) Harriet Prior et al.   G3-Genes Genomes Genetics

Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa

(2016) Gavin Arno et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

(2016) Yen-Sin Ang et al.   CELL

Approaching Perfection: New Developments in Zebrafish Genome Engineering

(2016) Arish N. Shah et al.   DEVELOPMENTAL CELL

Precise Editing of the Zebrafish Genome Made Simple and Efficient

(2016) Kazuyuki Hoshijima et al.   DEVELOPMENTAL CELL

CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22 R619W Mutation Increases Autoimmune Diabetes

(2016) Xiaotian Lin et al.   DIABETES

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

(2016) Alejandro Sifrim et al.   NATURE GENETICS

A HAND2 Loss-of-Function Mutation Causes Familial Ventricular Septal Defect and Pulmonary Stenosis

(2016) Yu-Min Sun et al.   G3-Genes Genomes Genetics

De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects

(2016) James R. Priest et al.   PLoS Genetics

BATCH-GE: Batch analysis of Next-Generation Sequencing data for genome editing assessment

(2016) Annekatrien Boel et al.   Scientific Reports

MEIS2involvement in cardiac development, cleft palate, and intellectual disability

(2015) Jacoba J. Louw et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ZFIN, The zebrafish model organism database: Updates and new directions

(2015) Leyla Ruzicka et al.   GENESIS

Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

(2015) Behnom Farboud et al.   GENETICS

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9

(2015) Gaurav K. Varshney et al.   GENOME RESEARCH

A novel HAND2 loss-of-function mutation responsible for tetralogy of Fallot

(2015) CAI-XIA LU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data

(2015) Caroline F Wright et al.   LANCET

De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

(2015) J. Homsy et al.   SCIENCE

Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

(2015) Behnom Farboud et al.   GENETICS

Utility and limitations of animal models for the functional validation of human sequence variants

(2015) Timothy C. Cox   Molecular Genetics & Genomic Medicine

Interpreting human genetic variation with in vivo zebrafish assays

(2014) Erica E. Davis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Making designer mutants in model organisms

(2014) Y. Peng et al.   DEVELOPMENT

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system

(2014) U. Irion et al.   DEVELOPMENT

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

Functionally Significant, Rare Transcription Factor Variants in Tetralogy of Fallot

(2014) Ana Töpf et al.   PLoS One

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Defects of protein production in erythroid cells revealed in a zebrafish Diamond–Blackfan anemia model for mutation in RPS19

(2014) Y Zhang et al.   Cell Death & Disease

Complex Genetics and the Etiology of Human Congenital Heart Disease

(2014) B. D. Gelb et al.   Cold Spring Harbor Perspectives in Medicine

Developmental Fate and Cellular Maturity Encoded in Human Regulatory DNA Landscapes

(2013) Andrew B. Stergachis et al.   CELL

Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos

(2013) Nannan Chang et al.   CELL RESEARCH

Genetics of Congenital Heart Disease

(2013) Akl C. Fahed et al.   CIRCULATION RESEARCH

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

(2013) A. Hruscha et al.   DEVELOPMENT

Glimpse into Hox and tale regulation of cell differentiation and reprogramming

(2013) Nuria Cerdá-Esteban et al.   DEVELOPMENTAL DYNAMICS

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death

(2013) Inken G. Huttner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

De novo mutations in histone-modifying genes in congenital heart disease

(2013) Samir Zaidi et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System

(2013) Woong Y. Hwang et al.   PLoS One

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The CRISPR System—Keeping Zebrafish Gene Targeting Fresh

(2013) Patrick R. Blackburn et al.   Zebrafish

From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes

(2013) Benjamin Georgi et al.   PLoS Genetics

Uncovering the Molecular and Cellular Mechanisms of Heart Development Using the Zebrafish

(2012) David Staudt et al.   Annual Review of Genetics

A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development

(2012) Sharon L. Paige et al.   CELL

Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

(2012) Joseph A. Wamstad et al.   CELL

Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects

(2012) Cammon B. Arrington et al.   European Journal of Medical Genetics

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo

(2012) Chaitali Misra et al.   PLoS Genetics

Epigenetics and Cardiovascular Development

(2011) Ching-Pin Chang et al.   Annual Review of Physiology

A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis

(2011) Elisabetta Ferretti et al.   DEVELOPMENTAL CELL

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

(2011) Fuqiang Chen et al.   NATURE METHODS

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart

(2011) A. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Further evidence for the possible role ofMEIS2in the development of cleft palate and cardiac septum

(2010) Moira A. Crowley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Myocardial Lineage Development

(2010) Sylvia M. Evans et al.   CIRCULATION RESEARCH

Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease

(2010) B Stallmeyer et al.   CLINICAL GENETICS

hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches

(2010) J. C. Talbot et al.   DEVELOPMENT

Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function

(2010) Z. V. Garavito-Aguilar et al.   DEVELOPMENT

Pbx acts with Hand2 in early myocardial differentiation

(2009) Lisa Maves et al.   DEVELOPMENTAL BIOLOGY

Meis Cofactors Control HDAC and CBP Accessibility at Hox-Regulated Promoters during Zebrafish Embryogenesis

(2009) Seong-Kyu Choe et al.   DEVELOPMENTAL CELL

Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease

(2008) Kryn Stankunas et al.   CIRCULATION RESEARCH

Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract

(2008) C.-P. Chang et al.   DEVELOPMENT