Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: a focus on gastrointestinal cancer

Targeting Histone Deacetylases in Diseases: Where Are We?

(2015) Rosaria Benedetti et al.   ANTIOXIDANTS & REDOX SIGNALING

Nanoparticle-Delivered Quercetin for Cancer Therapy

(2014) Ke Men et al.   Anti-Cancer Agents in Medicinal Chemistry

Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade

(2014) B. N. Singh et al.   CANCER AND METASTASIS REVIEWS

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

(2014) David B. Henley et al.   CURRENT MEDICAL RESEARCH AND OPINION

Curcumin in Combined Cancer Therapy

(2014) Koraljka Troselj et al.   CURRENT PHARMACEUTICAL DESIGN

3β-Acetyl tormentic acid reverts MRP1/ABCC1 mediated cancer resistance through modulation of intracellular levels of GSH and inhibition of GST activity

(2014) Gleice da Graça Rocha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Tea, Coffee, and Milk Consumption and Colorectal Cancer Risk

(2014) Chadwick John Green et al.   JOURNAL OF EPIDEMIOLOGY

Dendrofalconerol A sensitizes anoikis and inhibits migration in lung cancer cells

(2014) Premkamol Pengpaeng et al.   Journal of Natural Medicines

Photochemotherapy using natural anthraquinones: Rubiadin and Soranjidiol sensitize human cancer cell to die by apoptosis

(2014) Natalia Belen Rumie Vittar et al.   Photodiagnosis and Photodynamic Therapy

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

(2013) Tien-Yuan Wu et al.   AAPS Journal

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

(2013) Stephen P. Fortmann et al.   ANNALS OF INTERNAL MEDICINE

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

(2013) Xue-Jun Wang et al.   Asian Pacific Journal of Cancer Prevention

Curcumin Effect on MMPs and TIMPs Genes in a Breast Cancer Cell Line

(2013) Zeinab Korany Hassan et al.   Asian Pacific Journal of Cancer Prevention

Vitamin E: A dark horse at the crossroad of cancer management

(2013) Eduardo Cardenas et al.   BIOCHEMICAL PHARMACOLOGY

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular mechanisms of curcumin action: Signal transduction

(2013) Adeeb Shehzad et al.   BIOFACTORS

Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and  -Catenin

(2013) S. M. Saud et al.   CANCER RESEARCH

Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling

(2013) Y. Li et al.   CARCINOGENESIS

Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR

(2013) N. Banerjee et al.   CARCINOGENESIS

Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction

(2013) S. Martin et al.   CURRENT MEDICINAL CHEMISTRY

The Importance of the Retinoid X Receptor Alpha in Modulating Inflammatory Signaling in Acute Murine Colitis

(2013) Rebecca Knackstedt et al.   DIGESTIVE DISEASES AND SCIENCES

Colorectal cancer through simulation and experiment

(2013) Sophie K. Kershaw et al.   IET Systems Biology

Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells

(2013) YUNJUAN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Antitumor Activity of 2-Hydroxycinnamaldehyde for Human Colon Cancer Cells through Suppression of β-Catenin Signaling

(2013) Min Ai Lee et al.   JOURNAL OF NATURAL PRODUCTS

Molecular Approaches Toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and Other Signal Pathways

(2013) Anisur Rahman Khuda-Bukhsh et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Identification of plant extracts sensitizing breast cancer cells to TRAIL

(2013) SHERIF ABDELHAMED et al.   ONCOLOGY REPORTS

Tissue-Dependent Consequences of Apc Inactivation on Proliferation and Differentiation of Ciliated Cell Progenitors via Wnt and Notch Signaling

(2013) Aimin Li et al.   PLoS One

Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century

(2013) Soodabeh Saeidnia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The larva of Drusus vinconi Sipahiler, 1992 (Trichoptera, Limnephilidae, Drusinae)

(2013) Johann Waringer et al.   ZooKeys

Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai Women's Health Study

(2012) Sarah Nechuta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

(2012) Poyil Pratheeshkumar et al.   Anti-Cancer Agents in Medicinal Chemistry

Epigenetic mechanisms in anti-cancer actions of bioactive food components - the implications in cancer prevention

(2012) B Stefanska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Does Vitamin E Prevent or Promote Cancer?

(2012) C. S. Yang et al.   Cancer Prevention Research

Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition

(2012) Yang Yang et al.   CELLULAR SIGNALLING

Cancer Chemoprevention: Successes and Failures

(2012) S. L. Patterson et al.   CLINICAL CHEMISTRY

Medicinal Properties of the Jamaican Pepper Plant Pimenta dioica and Allspice

(2012) Lei Zhang et al.   CURRENT DRUG TARGETS

A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

(2012) Márcio Carocho et al.   FOOD AND CHEMICAL TOXICOLOGY

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells

(2012) Yujuan Shan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Scutellaria baicalensis Alleviates Cantharidin-Induced Rat Hemorrhagic Cystitis through Inhibition of Cyclooxygenase-2 Overexpression

(2012) Steven Kuan-Hua Huan et al.   MOLECULES

Green Tea and Incidence of Colorectal Cancer: Evidence from Prospective Cohort Studies

(2012) Zhen-Hua Wang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2

(2012) CHIA-MING CHANG et al.   ONCOLOGY REPORTS

Dietary Agents in Cancer Prevention: An Immunological Perspective†

(2012) Ya Ying Zheng et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Chemosensitization of tumors by resveratrol

(2011) Subash C. Gupta et al.   Annals of the New York Academy of Sciences

Tocotrienols: inflammation and cancer

(2011) Kalanithi Nesaretnam et al.   Annals of the New York Academy of Sciences

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010

(2011) D M Parkin et al.   BRITISH JOURNAL OF CANCER

Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

(2011) Chia-Jui Weng et al.   CANCER TREATMENT REVIEWS

Green tea consumption and colorectal cancer risk: a report from the Shanghai Men's Health Study

(2011) G. Yang et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Complex interplay between  -catenin signalling and Notch effectors in intestinal tumorigenesis

(2011) G. Peignon et al.   GUT

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis

(2011) Yi-Ping Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Vitamins in Cancer: A Review

(2011) Ana Catarina Mamede et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Impact of Curcumin, Raspberry Extract, and Neem Leaf Extract on Rel Protein-Regulated Cell Death/Radiosensitization in Pancreatic Cancer Cells

(2011) Jamunarani Veeraraghavan et al.   PANCREAS

Cancer prevention by tea: Evidence from laboratory studies

(2011) Chung S. Yang et al.   PHARMACOLOGICAL RESEARCH

Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors

(2011) Sanjit K. Roy et al.   PLoS One

Epigenetic diet: impact on the epigenome and cancer

(2011) Tabitha M Hardy et al.   Epigenomics

Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways

(2011) Yiwei Li et al.   Nutrients

Molecular pathways and targets in cancer-related inflammation

(2010) Alberto Mantovani et al.   ANNALS OF MEDICINE

Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials

(2010) Adeeb Shehzad et al.   ARCHIV DER PHARMAZIE

Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells

(2010) Esmerina Tili et al.   BIOCHEMICAL PHARMACOLOGY

Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy

(2010) Claudia Cerella et al.   BIOCHEMICAL PHARMACOLOGY

A New Cyclooxygenase-2 Inhibitor, (1E,4E)-1,5-Bis(2-bromophenyl)penta-1,4-dien-3-one (GL63) Suppresses Cyclooxygenase-2 Gene Expression in Human Lung Epithelial Cancer Cells: Coupled mRNA Stabilization and Posttranscriptional Inhibition

(2010) Jian Xiao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Resveratrol Inhibits Angiogenic Response of Cultured Endothelial F-2 Cells to Vascular Endothelial Growth Factor, but Not to Basic Fibroblast Growth Factor

(2010) Tomomi Uchiyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer

(2010) Giridhar Mudduluru et al.   BIOSCIENCE REPORTS

Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-κB

(2010) Ida Grotterød et al.   BMC CANCER

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

(2010) Limin Shu et al.   CANCER AND METASTASIS REVIEWS

Sulforaphane Inhibits Constitutive and Interleukin-6-Induced Activation of Signal Transducer and Activator of Transcription 3 in Prostate Cancer Cells

(2010) E. R. Hahm et al.   Cancer Prevention Research

Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

(2010) X. Cui et al.   Cancer Prevention Research

Regulation of Minichromosome Maintenance Gene Family by MicroRNA-1296 and Genistein in Prostate Cancer

(2010) Shahana Majid et al.   CANCER RESEARCH

Chemopreventive Agent 3,3'-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases

(2010) Y. Li et al.   CANCER RESEARCH

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

(2010) Esmerina Tili et al.   CARCINOGENESIS

Protective Effect of Sulforaphane on Human Vascular Endothelial Cells Against Lipopolysaccharide-Induced Inflammatory Damage

(2010) Yujuan Shan et al.   Cardiovascular Toxicology

Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

(2010) J. Weissenberger et al.   CLINICAL CANCER RESEARCH

Targeting Wnt Signaling in Colon Cancer Stem Cells

(2010) E. M. F. de Sousa et al.   CLINICAL CANCER RESEARCH

Impact on DNA Methylation in Cancer Prevention and Therapy by Bioactive Dietary Components

(2010) Y. Li et al.   CURRENT MEDICINAL CHEMISTRY

Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice

(2010) Susana Sánchez-Fidalgo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion

(2010) Helena Malhomme de la Roche et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

(2010) Jose L. Medina-Franco et al.   MOLECULAR DIVERSITY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Nanochemoprevention: Sustained Release of Bioactive Food Components for Cancer Prevention

(2010) Imtiaz A. Siddiqui et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer

(2010) Sanjeev Banerjee et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Vegetables, Fruits, and Colorectal Cancer Risk: What Should We Believe?

(2010) Young-In Kim   NUTRITION REVIEWS

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?

(2010) Maria Russo et al.   Toxins

Guidelines for Prevention of NSAID-Related Ulcer Complications

(2009) Frank L Lanza et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Green Tea Consumption and Mortality among Japanese Elderly People: The Prospective Shizuoka Elderly Cohort

(2009) Etsuji Suzuki et al.   ANNALS OF EPIDEMIOLOGY

Quantifying cancer progression with conjunctive Bayesian networks

(2009) M. Gerstung et al.   BIOINFORMATICS

Five-Year Efficacy and Safety Analysis of the Adenoma Prevention with Celecoxib Trial

(2009) M. M. Bertagnolli et al.   Cancer Prevention Research

Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

(2009) Y. Li et al.   CANCER RESEARCH

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

Cellular signaling perturbation by natural products

(2009) Fazlul H. Sarkar et al.   CELLULAR SIGNALLING

Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy

(2009) D.P. Do et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Perspectives for Cancer Prevention With Natural Compounds

(2009) A.R.M. Ruhul Amin et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells

(2009) Wing Pui Tsang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Total and Cancer Mortality After Supplementation With Vitamins and Minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial

(2009) Y.-L. Qiao et al.   JNCI-Journal of the National Cancer Institute

Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

(2009) Jack Cuzick et al.   LANCET ONCOLOGY

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells

(2009) Jie Yang et al.   MEDICAL ONCOLOGY

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane-ApcMin/+mouse model of intestinal cancer

(2009) Suresh R. Volate et al.   MOLECULAR CARCINOGENESIS

Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate

(2009) L.F. Heinecke et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of (−)-epigallocatechin-3-gallate on cyclooxygenase 2, PGE2, and IL-8 expression induced by IL-1β in human synovial fibroblasts

(2009) Guo-Shu Huang et al.   RHEUMATOLOGY INTERNATIONAL

Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

(2009) R. E. Harris   INFLAMMOPHARMACOLOGY

Cyclooxygenase-2 Expression during Immortalization and Breast Cancer Progression

(2008) X. Zhao et al.   CANCER RESEARCH

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

(2008) H. Nian et al.   CARCINOGENESIS

Antiplatelet Drugs

(2008) Carlo Patrono et al.   CHEST

Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-κB activation pathway

(2008) Luting Xu et al.   IMMUNOLOGY LETTERS

A new prostate cancer therapeutic approach: Combination of androgen ablation with COX-2 inhibitor

(2008) Yi Cai et al.   INTERNATIONAL JOURNAL OF CANCER

Vitamins E and C in the Prevention of Prostate and Total Cancer in Men

(2008) J. Michael Gaziano et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green Tea Polyphenol Epigallocatechin-3-Gallate Suppresses Collagen Production and Proliferation in Keloid Fibroblasts via Inhibition of the STAT3-Signaling Pathway

(2008) Gyuman Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2

(2008) Na Lu et al.   LIFE SCIENCES

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

(2008) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

(2008) Bharat B. Aggarwal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES