Epigenetic mechanisms in anti-cancer actions of bioactive food components - the implications in cancer prevention

Modulation of Histone Acetylation by Garlic Sulfur Compounds

(2012) Nathalie Druesne-Pecollo et al.   Anti-Cancer Agents in Medicinal Chemistry

The early-life social environment and DNA methylation

(2012) M Szyf   CLINICAL GENETICS

Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells

(2011) Limin Shu et al.   AAPS Journal

Dietary B Vitamin and Methionine Intakes and Breast Cancer Risk Among Chinese Women

(2011) M. J. Shrubsole et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells

(2011) Barbara Stefanska et al.   BRITISH JOURNAL OF NUTRITION

Chemoprevention of Intestinal Polyps in ApcMin/+ Mice Fed with Western or Balanced Diets by Drinking Annurca Apple Polyphenol Extract

(2011) L. Fini et al.   Cancer Prevention Research

Definition of the Landscape of Promoter DNA Hypomethylation in Liver Cancer

(2011) B. Stefanska et al.   CANCER RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Epigenetic aberrations during oncogenesis

(2011) Maria Hatziapostolou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic modifications in cancer

(2011) R Kanwal et al.   CLINICAL GENETICS

Translational application of epigenetic alterations: Ovarian cancer as a model

(2011) Marie E. Maradeo et al.   FEBS LETTERS

Genome-wide function of H2B ubiquitylation in promoter and genic regions

(2011) K. Batta et al.   GENES & DEVELOPMENT

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

Folic acid supplementation during early hepatocarcinogenesis: Cellular and molecular effects

(2011) Carlos Eduardo Andrade Chagas et al.   INTERNATIONAL JOURNAL OF CANCER

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties

(2011) Mahmoud Alhosin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 Cells

(2011) Andreas J. Papoutsis et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

MicroRNAs, diet, and cancer: New mechanistic insights on the epigenetic actions of phytochemicals

(2011) Mansi A. Parasramka et al.   MOLECULAR CARCINOGENESIS

Enhancing the bioavailability of resveratrol by combining it with piperine

(2011) Jeremy J. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Histone onco-modifications

(2011) J Füllgrabe et al.   ONCOGENE

Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus

(2011) T. Watanabe et al.   SCIENCE

MicroRNAs in the Pathogenesis of Cancer

(2011) Francesca Lovat et al.   SEMINARS IN ONCOLOGY

From Waddington’s epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research

(2011) Supratim Choudhuri   TOXICOLOGY MECHANISMS AND METHODS

Impact of vitamin D metabolism on clinical epigenetics

(2011) Heidrun Karlic et al.   Clinical Epigenetics

Epigenetic Control of Estrogen Receptor Expression and Tumor Suppressor Genes Is Modulated by Bioactive Food Compounds

(2010) Carolin Berner et al.   ANNALS OF NUTRITION AND METABOLISM

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific MortalityMeta-analysis of 8 Randomized Trials Involving 37 485 IndividualsEffects of Lowering Homocysteine Levels

(2010)   ARCHIVES OF INTERNAL MEDICINE

Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders

(2010) Katarzyna Szarc vel Szic et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells

(2010) Esmerina Tili et al.   BIOCHEMICAL PHARMACOLOGY

Interplay between microRNAs and the epigenetic machinery: An intricate network

(2010) Marilena V. Iorio et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Non-coding RNAs and their epigenetic regulatory mechanisms

(2010) Huihui Zhou et al.   BIOLOGY OF THE CELL

Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells

(2010) Gaia Bistulfi et al.   BMC BIOLOGY

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer

(2010) Alexandros Daskalos et al.   CANCER

DNA methylation-related vitamin D receptor insensitivity in breast cancer

(2010) Radharani Marik et al.   CANCER BIOLOGY & THERAPY

MicroRNA Mediates DNA Demethylation Events Triggered by Retinoic Acid during Neuroblastoma Cell Differentiation

(2010) S. Das et al.   CANCER RESEARCH

PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation

(2010) O. M. Rahal et al.   CARCINOGENESIS

Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro

(2010) T.-c. Hsieh et al.   CARCINOGENESIS

Modulation of Genetic and Epigenetic Biomarkers of Colorectal Cancer in Humans by Black Raspberries: A Phase I Pilot Study

(2010) L.-S. Wang et al.   CLINICAL CANCER RESEARCH

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1

(2010) Tanveer Sharif et al.   EUROPEAN JOURNAL OF CANCER

Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells

(2010) Barbara Stefanska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

(2010) Samir Attoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2′-deoxycytidine-induced PTEN upregulation

(2010) Lina Pan et al.   FEBS Journal

Epigenetics and cancer

(2010) Rajnee Kanwal et al.   JOURNAL OF APPLIED PHYSIOLOGY

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis

(2010) Susan J. Duthie   JOURNAL OF INHERITED METABOLIC DISEASE

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

(2010) Christian Popp et al.   NATURE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

MEGALOBLASTIC CHANGES IN THE CERVICAL EPITHELIUM. Association with Oral Contraceptive Therapy and Reversal with Folic Acid

(2010) Nancy Whitehead et al.   NUTRITION REVIEWS

Diet, MicroRNAs and Prostate Cancer

(2010) Sharanjot Saini et al.   PHARMACEUTICAL RESEARCH

Histone modification levels are predictive for gene expression

(2010) R. Karlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Determination of enriched histone modifications in non-genic portions of the human genome

(2009) Jeffrey A Rosenfeld et al.   BMC GENOMICS

Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cellsin vitroand inhibits tumor growthin vivo

(2009) Yu Bai et al.   CANCER SCIENCE

BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer

(2009) S. Majid et al.   CARCINOGENESIS

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer

(2009) J. Shaikh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Vanillin cross-linked chitosan microspheres for controlled release of resveratrol

(2009) Hailong Peng et al.   FOOD CHEMISTRY

Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12

(2009) Marta Ebbing   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D3

(2009) Anna Saramäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspectives for Cancer Prevention With Natural Compounds

(2009) A.R.M. Ruhul Amin et al.   JOURNAL OF CLINICAL ONCOLOGY

Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons

(2009) A. Unterberger et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide

(2009) Z. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Soy Isoflavones Have an Antiestrogenic Effect and Alter Mammary Promoter Hypermethylation in Healthy Premenopausal Women

(2009) Wenyi Qin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A human B cell methylome at 100−base pair resolution

(2009) Tibor A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells

(2009) Jarosław Paluszczak et al.   TOXICOLOGY LETTERS

Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk

(2008) Sonia S Maruti et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Epigenetic regulation of human buccal mucosa mitochondrial superoxide dismutase gene expression by diet

(2008) Roman Thaler et al.   BRITISH JOURNAL OF NUTRITION

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

Quercetin Is Able to Demethylate the p16INK4a Gene Promoter

(2008) Sainan Tan et al.   CHEMOTHERAPY

Retracted: Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

(2008) Nobuyuki Kikuno et al.   INTERNATIONAL JOURNAL OF CANCER

p21 is required for atRA-mediated growth inhibition of MEPM cells, which involves RAR

(2008) Zengli Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vitamin D-Dependent Recruitment of Corepressors to Vitamin D/Retinoid X Receptor Heterodimers

(2008) R. Sanchez-Martinez et al.   MOLECULAR AND CELLULAR BIOLOGY

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds

(2008) Chung S Yang et al.   NUTRITION REVIEWS

Evidence for dietary regulation of microRNA expression in cancer cells

(2008) Cindy D Davis et al.   NUTRITION REVIEWS

Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and MDA-MB-453 cells

(2008) Eun Jeong Choi et al.   PHYTOMEDICINE

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the mechanism of demethylation of 5-methylcytosine in DNA

(2007) Stefan Hamm et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest

(2007) Yi Cui et al.   LIFE SCIENCES