Molecular mechanisms of curcumin action: Signal transduction

Curcumin: Multiple molecular targets mediate multiple pharmacological actions: A review

(2015) A. Shehzad et al.   DRUGS OF THE FUTURE

The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway

(2012) Weixun Duan et al.   BASIC RESEARCH IN CARDIOLOGY

AMP-activated protein kinase, stress responses and cardiovascular diseases

(2012) Shaobin Wang et al.   CLINICAL SCIENCE

Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC–MAPK signaling pathway

(2012) Vivian Soetikno et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Curcumin-Induced Apoptosis in Human Hepatocellular Carcinoma J5 Cells: Critical Role ofCa+2-Dependent Pathway

(2012) Wei-Hsun Wang et al.   Evidence-based Complementary and Alternative Medicine

Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling

(2012) Yonggang Li et al.   FEBS Journal

Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway

(2012) Hsiang-Ping Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory Mechanism of 15,16-Epoxy-3α-hydroxylabda-8,13(16),14-trien-7-one via Inhibition of LPS-Induced Multicellular Signaling Pathways

(2012) Salman Khan et al.   JOURNAL OF NATURAL PRODUCTS

Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized Rats

(2012) Edilia Tapia et al.   Oxidative Medicine and Cellular Longevity

Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling

(2012) Dharmalingam Subramaniam et al.   PLoS One

Curcumin Attenuates β-catenin Signaling in Prostate Cancer Cells through Activation of Protein Kinase D1

(2012) Vasudha Sundram et al.   PLoS One

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

(2012) Wenqing Cai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Curcumin suppresses TGF-β signaling by inhibition of TGIF degradation in scleroderma fibroblasts

(2011) Kemin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin

(2011) Zhen-Yu He et al.   CANCER INVESTIGATION

New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases

(2011) Adeeb Shehzad et al.   EUROPEAN JOURNAL OF NUTRITION

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin Attenuates Insulin Resistance in Hepatocytes by Inducing Nrf2 Nuclear Translocation

(2011) Shu-Guang Zhao et al.   HEPATO-GASTROENTEROLOGY

Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways

(2011) Shengkai Liao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation

(2011) Hong-Sheng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Curcumin potentiates antitumor activity ofl-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia

(2011) Hua Wang et al.   LEUKEMIA & LYMPHOMA

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase 2 by Curcumin Induces ER Stress-Associated Apoptosis for Treating Human Liposarcoma

(2011) L. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Preventive Effects of Curcumin on the Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Male C57BL/KsJ-db/dbObese Mice

(2011) Masaya Kubota et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Curcumin Inhibits Neuronal and Vascular Degeneration in Retina after Ischemia and Reperfusion Injury

(2011) Leilei Wang et al.   PLoS One

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells

(2010) Jane L. Watson et al.   CANCER LETTERS

Differential Inhibition of Protein Translation Machinery by Curcumin in Normal, Immortalized, and Malignant Oral Epithelial Cells

(2010) N. Chakravarti et al.   Cancer Prevention Research

Wnt/β-Catenin/LEF-1 Signaling in Chronic Lymphocytic Leukemia (CLL): A Target for Current and Potential Therapeutic Options

(2010) R. K. Gandhirajan et al.   CURRENT CANCER DRUG TARGETS

Lesson Learned from Nature for the Development of Novel Anti-Cancer Agents: Implication of Isoflavone, Curcumin, and their Synthetic Analogs

(2010) Fazlul H. Sarkar et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPα during oral cancer suppression

(2010) Kuo-Wei Chang et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Regulatory Effect of the AMPK-COX-2 Signaling Pathway in Curcumin-Induced Apoptosis in HT-29 Colon Cancer Cells

(2009) Yun-Kyoung Lee et al.   Annals of the New York Academy of Sciences

Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis

(2009) Ming Liu et al.   BIOPHYSICAL CHEMISTRY

Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: Their inhibition by curcumin

(2009) Ji Hye Seo et al.   CANCER LETTERS

Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/β-catenin signaling

(2009) Chandra P. Prasad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer

(2009) Young-Hoon Joo et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway

(2008) Song-Shei Lin et al.   CANCER LETTERS

Curcumin and cancer: An “old-age” disease with an “age-old” solution

(2008) Preetha Anand et al.   CANCER LETTERS

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Curcumin Exerts Antidifferentiation Effect through AMPKα-PPAR-γ in 3T3-L1 Adipocytes and Antiproliferatory Effect through AMPKα-COX-2 in Cancer Cells

(2008) Yun K. Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL)

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL ONCOLOGY

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

(2008) S. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets

(2008) Heena D. Panchal et al.   NEUROCHEMICAL RESEARCH

Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials

(2007) Alexios S. Strimpakos et al.   ANTIOXIDANTS & REDOX SIGNALING