Potential therapeutic targets for atherosclerosis in sphingolipid metabolism

Plasma Ceramides

(2018) Jeffrey W. Meeusen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The inhibition of sphingomyelin synthase 1 activity induces collecting duct cells to lose their epithelial phenotype

(2018) Yamila Romina Brandán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Could Ceramides Become the New Cholesterol?

(2018) Scott A. Summers   Cell Metabolism

Intensive Metabolic Control of T1D Pregnant Women in CSII vs. MDI—A Retrospective Analysis

(2018) SARA PARRETTINI et al.   DIABETES

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B—The Strong Heart Family Study

(2018) ROZENN N. LEMAITRE et al.   DIABETES

Sphingosine 1-Phosphate and Atherosclerosis

(2018) Makoto Kurano et al.   Journal of Atherosclerosis and Thrombosis

Ceramide Remodeling and Risk of Cardiovascular Events and Mortality

(2018) Linda R. Peterson et al.   Journal of the American Heart Association

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

(2018) Mélanie Campana et al.   Molecular Metabolism

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

(2018) Ian J. Neeland et al.   DIABETOLOGIA

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4–mediated suppression of 5-lipoxygenase activity

(2018) Jasmin Fettel et al.   FASEB JOURNAL

The effect of high-fat diet and inhibition of ceramide production on insulin action in liver

(2018) Piotr Zabielski et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of 4-Benzyloxybenzo[d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/db Mice

(2018) Mingguang Mo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors

(2017) Ryutaro Adachi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease

(2017) Amin Polzin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

(2017) Leonore Wigger et al.   Cell Reports

Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

(2017) William L. Holland et al.   Molecular Metabolism

Adiponectin serenades ceramidase to improve metabolism

(2017) Saskia Reibe-Pal et al.   Molecular Metabolism

Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging

(2016) Elisa Fabbri et al.   AGING CELL

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 CohortHighlights

(2016) Aki S. Havulinna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice

(2016) Masayuki Sugimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases

(2016) Mohamad Adada et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

(2016) Reijo Laaksonen et al.   EUROPEAN HEART JOURNAL

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

(2016) Peter J. Meikle et al.   Nature Reviews Endocrinology

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

(2016) Anke Wittmann et al.   PLoS One

Metabolic syndrome update

(2016) Scott M. Grundy   TRENDS IN CARDIOVASCULAR MEDICINE

Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis

(2016) Linda Sasset et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans

(2015) Bryan C. Bergman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tumor suppressive functions of ceramide: evidence and mechanisms

(2015) Sehamuddin Galadari et al.   APOPTOSIS

Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study

(2015) Jin M. Cheng et al.   ATHEROSCLEROSIS

Prevention of cardiac hypertrophy by the use of a glycosphingolipid synthesis inhibitor in ApoE−/− mice

(2015) Sumita Mishra et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity

(2015) S. Rodriguez-Cuenca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Improved intervention of atherosclerosis and cardiac hypertrophy through biodegradable polymer-encapsulated delivery of glycosphingolipid inhibitor

(2015) S. Mishra et al.   BIOMATERIALS

Influence of Hydroxylation, Chain Length, and Chain Unsaturation on Bilayer Properties of Ceramides

(2015) Terhi Maula et al.   BIOPHYSICAL JOURNAL

Ceramide Is Upregulated and Associated With Mortality in Patients With Chronic Heart Failure

(2015) Jingjia Yu et al.   CANADIAN JOURNAL OF CARDIOLOGY

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide

(2015) Jahangir Iqbal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity

(2015) Tingbo Ding et al.   JOURNAL OF LIPID RESEARCH

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice

(2015) Andreas Bickert et al.   JOURNAL OF LIPID RESEARCH

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

(2014) Philipp Ebel et al.   BIOCHEMICAL JOURNAL

The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes

(2014) Nimesh Mody et al.   BIOCHEMICAL PHARMACOLOGY

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

C16:0-Ceramide Signals Insulin Resistance

(2014) Timothy Hla et al.   Cell Metabolism

HDL-Bound Sphingosine 1-Phosphate (S1P) Predicts the Severity of Coronary Artery Atherosclerosis

(2014) Katherine Sattler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apolipoprotein E −/− Mice and Rabbits Fed a High-Fat and -Cholesterol Diet

(2014) Subroto Chatterjee et al.   CIRCULATION

A not-stop-flow online normal-/reversed-phase two-dimensional liquid chromatography–quadrupole time-of-flight mass spectrometry method for comprehensive lipid profiling of human plasma from atherosclerosis patients

(2014) Min Li et al.   JOURNAL OF CHROMATOGRAPHY A

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Glycerophospholipid and Sphingolipid Species and Mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

(2014) Alexander Sigruener et al.   PLoS One

Ceramide: A simple sphingolipid with unique biophysical properties

(2014) Bruno M. Castro et al.   PROGRESS IN LIPID RESEARCH

KRP-203, Sphingosine 1-Phosphate Receptor Type 1 Agonist, Ameliorates Atherosclerosis in LDL-R −/− Mice

(2013) Francesco Potì et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingomyelin Synthase 2 Activity and Liver Steatosis

(2013) Yue Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction

(2013) Mark J. Dekker et al.   ATHEROSCLEROSIS

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders

(2013) Makoto Taniguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Identification of small molecule sphingomyelin synthase inhibitors

(2013) Xiaodong Deng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities

(2013) Philipp Ebel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Lipids Identify Cardiovascular Risk and Are Efficiently Lowered by Simvastatin andPCSK9Deficiency

(2013) Kirill Tarasov et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma ceramides are elevated in female children and adolescents with type 2 diabetes

(2013) Ximena Lopez et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice

(2013) Xiaogang Wang et al.   Lipids in Health and Disease

Inhibition of ceramidede novosynthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

(2013) Krzysztof Kurek et al.   LIVER INTERNATIONAL

Increased Oxidative Stress Impairs Adipose Tissue Function in Sphingomyelin Synthase 1 Null Mice

(2013) Masato Yano et al.   PLoS One

Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction

(2013) Małgorzata Knapp et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice

(2012) Zhiqiang Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fenretinide Ameliorates Insulin Resistance and Fatty Liver in Obese Mice

(2012) In-uk Koh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Sphingolipid Signaling in Metabolic Disorders

(2012) Timothy Hla et al.   Cell Metabolism

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

(2012) J. Boon et al.   DIABETES

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice

(2012) L. Dong et al.   INTERNATIONAL IMMUNOLOGY

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice

(2012) Mei-Hong Lu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sphingomyelin synthase 2 over-expression induces expression of aortic inflammatory biomarkers and decreases circulating EPCs in ApoE KO mice

(2012) Ya-Rui Zhao et al.   LIFE SCIENCES

Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R−/−) mice

(2012) Francesco Poti et al.   VASCULAR PHARMACOLOGY

Plasma Lipidomic Analysis of Stable and Unstable Coronary Artery Disease

(2011) Peter J. Meikle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E−/− mice

(2011) Andrew J. Leger et al.   JOURNAL OF GENE MEDICINE

S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease

(2011) Kelley M Argraves et al.   Lipids in Health and Disease

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

(2011) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Tricyclodecan-9-yl-Xanthogenate (D609) Mechanism of Actions: A Mini-Review of Literature

(2011) Rao Muralikrishna Adibhatla et al.   NEUROCHEMICAL RESEARCH

Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans

(2011) Xueying Chen et al.   Nutrition & Metabolism

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

Inhibition of Glycosphingolipid Synthesis Induces a Profound Reduction of Plasma Cholesterol and Inhibits Atherosclerosis Development in APOE*3 Leiden and Low-Density Lipoprotein Receptor−/− Mice

(2010) Florence Bietrix et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Selective Reduction in the Sphingomyelin Content of Atherogenic Lipoproteins Inhibits Their Retention in Murine Aortas and the Subsequent Development of Atherosclerosis

(2010) Yifan Fan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease

(2010) Katherine J. E. Sattler et al.   BASIC RESEARCH IN CARDIOLOGY

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

(2010) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood sphingolipidomics in healthy humans: impact of sample collection methodology

(2010) Samar M. Hammad et al.   JOURNAL OF LIPID RESEARCH

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

(2009) Frederic Preitner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sphingomyelin Synthase 2 Is One of the Determinants for Plasma and Liver Sphingomyelin Levels in Mice

(2009) Jing Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of Plasma Sphingomyelin Levels and Incident Coronary Heart Disease Events in an Adult Population

(2009) Joseph Yeboah et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice

(2009) Jing Liu et al.   CIRCULATION RESEARCH

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

(2009) V. D. F. de Mello et al.   DIABETOLOGIA

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice

(2009) Nora Bijl et al.   HEPATOLOGY

Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas

(2009) Silke Imgrund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

(2009) J. Michaud et al.   JOURNAL OF IMMUNOLOGY

Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

(2009) Marco van Eijk et al.   PLoS One

Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression

(2008) Cecilia M. Devlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

(2008) Tiruneh K. Hailemariam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of Fenretinide and Low-Dose Tamoxifen on Insulin Sensitivity in Premenopausal Women at High Risk for Breast Cancer

(2008) H. Johansson et al.   CANCER RESEARCH

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice

(2008) Elias N. Glaros et al.   JOURNAL OF LIPID RESEARCH

Effect of Sphingomyelinase-Mediated Generation of Ceramide on Aggregation of Low-Density Lipoprotein

(2008) Michael J. Walters et al.   LANGMUIR

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice

(2008) T PARK et al.   PHARMACOLOGICAL RESEARCH