Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy

Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-Derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy

(2018) Hathaichanok Phuengkham et al.   ADVANCED MATERIALS

Inhibition of tumor-promoting stroma to enforce subsequently targeting AT 1 R on tumor cells by pathological inspired micelles

(2018) Yun Zhu et al.   BIOMATERIALS

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment

(2017) Meirong Huo et al.   JOURNAL OF CONTROLLED RELEASE

Epigenetics and immunotherapy: The current state of play

(2017) Jennifer Dunn et al.   MOLECULAR IMMUNOLOGY

Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

(2017) Elie Dheilly et al.   MOLECULAR THERAPY

Tumor Microenvironment Responsive Nanogel for the Combinatorial Antitumor Effect of Chemotherapy and Immunotherapy

(2017) Qingle Song et al.   NANO LETTERS

Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy

(2017) Song Shen et al.   NANO LETTERS

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

(2017) N Cohen et al.   ONCOGENE

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

(2017) Jun Ishihara et al.   Science Translational Medicine

Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells

(2017) Haifa Shen et al.   SEMINARS IN IMMUNOLOGY

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Celecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice

(2017) Bo Zhang et al.   Scientific Reports

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

(2016) Yanqi Ye et al.   ACS Nano

Localized Multi-Component Delivery Platform Generates Local and Systemic Anti-Tumor Immunity

(2016) Abhinav P. Acharya et al.   ADVANCED FUNCTIONAL MATERIALS

Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy

(2016) Maria Stella Sasso et al.   BIOMATERIALS

Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy

(2016) Xiao Zhao et al.   BIOMATERIALS

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

(2016) Niels Halama et al.   CANCER CELL

The inhibition of epidermal growth factor receptor signaling by hexagonal selenium nanoparticles modified by SiRNA

(2016) L Kamrani Moghaddam et al.   CANCER GENE THERAPY

Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors

(2016) Lei Miao et al.   CANCER RESEARCH

Talimogene Laherparepvec for the Treatment of Advanced Melanoma

(2016) P. A. Ott et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Immune Checkpoint Antibodies and their Toxicities

(2016) S. Cousin et al.   CLINICAL CANCER RESEARCH

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Immune-related adverse events with immune checkpoint blockade: a comprehensive review

(2016) J.M. Michot et al.   EUROPEAN JOURNAL OF CANCER

Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation

(2016) Shi-Yong Li et al.   JOURNAL OF CONTROLLED RELEASE

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

(2016) Chao Wang et al.   NANO LETTERS

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Rekindling cancer vaccines

(2016) Malorye Allison Branca   NATURE BIOTECHNOLOGY

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

(2016) Celine Boutros et al.   Nature Reviews Clinical Oncology

FDA Approval Summary: Pembrolizumab for the Treatment of Patients With Metastatic Non-Small Cell Lung Cancer Whose Tumors Express Programmed Death-Ligand 1

(2016) Joohee Sul et al.   ONCOLOGIST

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology

(2016) Edward A. Sykes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy

(2016) Kazuhide Sato et al.   Science Translational Medicine

Advances in personalized cancer immunotherapy

(2016) Kazuhiro Kakimi et al.   Breast Cancer

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

(2016) Yichao Chen et al.   Nature Communications

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

(2015) Karlo Perica et al.   ACS Nano

Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells

(2015) João Conde et al.   ADVANCED FUNCTIONAL MATERIALS

Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma

(2015) Yan Zhao et al.   BIOMATERIALS

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

(2015) Laura Jeanbart et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma

(2015) Hideyuki Takahashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunoengineering: How Nanotechnology Can Enhance Cancer Immunotherapy

(2015) Michael S. Goldberg   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Toxicities of Immunotherapy for the Practitioner

(2015) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

IDO inhibitors move center stage in immuno-oncology

(2015) Cormac Sheridan   NATURE BIOTECHNOLOGY

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Three Steps to Breaking Immune Tolerance to Lymphoma: A Microparticle Approach

(2015) A. Makkouk et al.   Cancer Immunology Research

Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity

(2015) Yongkui Li et al.   OncoImmunology

Tumor cell lysates as immunogenic sources for cancer vaccine design

(2015) Fermín E González et al.   Human Vaccines & Immunotherapeutics

Biodegradable Microparticles Loaded with Doxorubicin and CpG ODN for In Situ Immunization Against Cancer

(2014) Amani Makkouk et al.   AAPS Journal

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

Nanoparticle-Based Immunotherapy for Cancer

(2014) Kun Shao et al.   ACS Nano

Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-CTLA-4 Therapy to Inhibit Cancer Metastasis

(2014) Chao Wang et al.   ADVANCED MATERIALS

Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy

(2014) Xiudan Zhan et al.   BIOMATERIALS

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model

(2014) Jing Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

Epigenetic drugs as immunomodulators for combination therapies in solid tumors

(2014) Luca Sigalotti et al.   PHARMACOLOGY & THERAPEUTICS

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

(2014) L. Xu et al.   Science Translational Medicine

In Vivo Targeting of Intratumor Regulatory T Cells Using PEG-Modified Single-Walled Carbon Nanotubes

(2013) Cristiano Sacchetti et al.   BIOCONJUGATE CHEMISTRY

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

(2013) Y. Huang et al.   CANCER RESEARCH

Docetaxel Conjugate Nanoparticles That Target  -Smooth Muscle Actin-Expressing Stromal Cells Suppress Breast Cancer Metastasis

(2013) M. Murakami et al.   CANCER RESEARCH

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell-Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

(2013) M. F. Fransen et al.   CLINICAL CANCER RESEARCH

FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells

(2013) Dewan Md Sakib Hossain et al.   IMMUNITY

Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells

(2013) Michael C. Jensen et al.   IMMUNOLOGICAL REVIEWS

Enhancement of All-TransRetinoic Acid-Induced Differentiation by pH-Sensitive Nanoparticles for Solid Tumor Cells

(2013) Yongjian Wang et al.   MACROMOLECULAR BIOSCIENCE

Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics

(2013) Xianwei Su et al.   MOLECULAR PHARMACEUTICS

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

(2013) M. Cieslewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

(2012) Matthias T. Stephan et al.   BIOMATERIALS

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)

(2012) Hao Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)‐b‐poly(dl‐lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine

(2012) Elham A. Mohamed et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications

(2012) Elodie Moysan et al.   MOLECULAR PHARMACEUTICS

EGF receptor-targeted nanocarriers for enhanced cancer treatment

(2012) Alyssa M Master et al.   Nanomedicine

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Biodegradable Thermosensitive Hydrogel for SAHA and DDP Delivery: Therapeutic Effects on Oral Squamous Cell Carcinoma Xenografts

(2012) Jing Li et al.   PLoS One

Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery

(2012) J. Predina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

(2012) Mi Kyung Yu et al.   Theranostics

The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer

(2011) P. Venkatesan et al.   BIOMATERIALS

Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status

(2011) J Šímová et al.   BRITISH JOURNAL OF CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy

(2011) Marc Baay et al.   Clinical & Developmental Immunology

Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

(2011) Zhen Huang et al.   JOURNAL OF CONTROLLED RELEASE

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Tumour macrophages as potential targets of bisphosphonates

(2011) Thea L Rogers et al.   Journal of Translational Medicine

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

Local Release of Highly Loaded Antibodies from Functionalized Nanoporous Support for Cancer Immunotherapy

(2010) Chenghong Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epigenetic modifications as therapeutic targets

(2010) Theresa K Kelly et al.   NATURE BIOTECHNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Key Role of Macrophages in the Pathogenesis of CD18 Hypomorphic Murine Model of Psoriasis

(2009) Honglin Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice

(2009) O. A. Ali et al.   Science Translational Medicine

TGFβ in Cancer

(2008) Joan Massagué   CELL

Reversal of Myeloid Cell-Mediated Immunosuppression in Patients with Metastatic Renal Cell Carcinoma

(2008) S. Kusmartsev et al.   CLINICAL CANCER RESEARCH

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JSI-124

(2008) Ommoleila Molavi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY