Celecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice

Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer

(2016) Bo Zhang et al.   BIOMATERIALS

Fibrin degradation by rtPA enhances the delivery of nanotherapeutics to A549 tumors in nude mice

(2016) Bo Zhang et al.   BIOMATERIALS

Fibrin-targeting peptide CREKA-conjugated multi-walled carbon nanotubes for self-amplified photothermal therapy of tumor

(2016) Bo Zhang et al.   BIOMATERIALS

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

UPA-sensitive ACPP-conjugated nanoparticles for multi-targeting therapy of brain glioma

(2015) Bo Zhang et al.   BIOMATERIALS

A Novel Combined Micellar System of Lapatinib and Paclitaxel with Enhanced Antineoplastic Effect Against Human Epidermal Growth Factor Receptor-2 Positive Breast Tumor In Vitro

(2015) Yan Wei et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer

(2015) Yiyao Zhang et al.   Oncotarget

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN

(2015) Tian-Huei Chu et al.   Oncotarget

Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo

(2015) Mahbuba Rahman et al.   NEOPLASIA

Co-delivery of Cisplatin and Rapamycin for Enhanced Anticancer Therapy through Synergistic Effects and Microenvironment Modulation

(2014) Shutao Guo et al.   ACS Nano

Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles

(2014) Bo Zhang et al.   BIOMATERIALS

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation

(2014) Hailiang Wu et al.   JOURNAL OF CONTROLLED RELEASE

Progress of drug-loaded polymeric micelles into clinical studies

(2014) Horacio Cabral et al.   JOURNAL OF CONTROLLED RELEASE

LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma

(2013) Bo Zhang et al.   BIOMATERIALS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

(2013) T. T. Batchelor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photoswitchable nanoparticles for in vivo cancer chemotherapy

(2013) R. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining two strategies to improve perfusion and drug delivery in solid tumors

(2013) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

A tissue factor targeted nanomedical system for thrombi-specific drug delivery

(2012) Wei Shi et al.   BIOMATERIALS

Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer

(2012) A. Kirane et al.   CLINICAL CANCER RESEARCH

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-targeted TNF  stabilizes tumor vessels and enhances active immunotherapy

(2012) A. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer

(2011) P. Venkatesan et al.   BIOMATERIALS

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps

(2011) Y. Nakanishi et al.   CARCINOGENESIS

Cox-2 inhibitors induce early c-Myc downregulation and lead to expression of differentiation markers in leukemia cells

(2011) Cyril Sobolewski et al.   CELL CYCLE

Effect of celecoxib on proliferation, collagen expression, ERK1/2 and SMAD2/3 phosphorylation in NIH/3T3 fibroblasts

(2011) Fengfeng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells

(2011) D. Chakroborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect

(2010) Sarbari Acharya et al.   ADVANCED DRUG DELIVERY REVIEWS

COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems

(2010) Hiroshi Katoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward

(2010) D. G. Menter et al.   CLINICAL CANCER RESEARCH

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

A Phase II Study of Celecoxib in Combination with Paclitaxel, Carboplatin, and Radiotherapy for Patients with Inoperable Stage IIIA/B Non-Small Cell Lung Cancer

(2009) R. Mutter et al.   CLINICAL CANCER RESEARCH

Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: Formulation, optimization and in vitro characterization

(2009) Zhang Wei et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH