Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development

Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics

(2018) Jinah Jang et al.   BIOMATERIALS

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

(2018) Xin Cui et al.   BIOMATERIALS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Modeling trastuzumab-related cardiotoxicity in vitro using human stem cell-derived cardiomyocytes

(2018) Yosuke K. Kurokawa et al.   TOXICOLOGY LETTERS

Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid

(2018) Sang Woo Lee et al.   Scientific Reports

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

(2018) Sharon Wei Ling Lee et al.   Frontiers in Immunology

3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro

(2017) Robert G. Mannino et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Paper-based cell culture platform and its emerging biomedical applications

(2017) Kelvin Ng et al.   Materials Today

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro

(2017) Ken-ichiro Kamei et al.   RSC Advances

3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study

(2016) Xuan Zhou et al.   ACS Applied Materials & Interfaces

Metabolic response of lung cancer cells to radiation in a paper-based 3D cell culture system

(2016) Karen A. Simon et al.   BIOMATERIALS

Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues

(2016) Petra Kerscher et al.   BIOMATERIALS

Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro

(2016) Sudong Kim et al.   BIOMATERIALS

Stromal-Based Signatures for the Classification of Gastric Cancer

(2016) M. T. Uhlik et al.   CANCER RESEARCH

Challenging Roadblocks to Cancer Cure

(2016) M. Loda   CANCER RESEARCH

Tumor Heterogeneity--A 'Contemporary Concept Founded on Historical Insights and Predictions

(2016) D. R. Welch   CANCER RESEARCH

Tumor spheroid assembly on hyaluronic acid-based structures: A review

(2016) Marco P. Carvalho et al.   CARBOHYDRATE POLYMERS

Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions

(2016) Jennifer Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture

(2016) Shantanu Pradhan et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A 3D printed nano bone matrix for characterization of breast cancer cell and osteoblast interactions

(2016) Wei Zhu et al.   NANOTECHNOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Directed migration of cancer cells guided by the graded texture of the underlying matrix

(2016) JinSeok Park et al.   NATURE MATERIALS

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

(2016) Sophia Frentzas et al.   NATURE MEDICINE

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology

(2016) Jeonghun Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clarifying intact 3D tissues on a microfluidic chip for high-throughput structural analysis

(2016) Yih Yang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes

(2016) Chris L. Smith et al.   Cell Reports

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis

(2016) Rachael Natrajan et al.   PLOS MEDICINE

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Rapid 3D Extrusion of Synthetic Tumor Microenvironments

(2015) Joshua M. Grolman et al.   ADVANCED MATERIALS

Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix

(2015) Amanda L. Placone et al.   BIOMATERIALS

A paper-based invasion assay: Assessing chemotaxis of cancer cells in gradients of oxygen

(2015) Bobak Mosadegh et al.   BIOMATERIALS

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

(2015) Nicholas McGranahan et al.   CANCER CELL

Clarifying Tissue Clearing

(2015) Douglas S. Richardson et al.   CELL

Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications

(2015) Jun Xu et al.   Cell Stem Cell

Synthetic tumor networks for screening drug delivery systems

(2015) Balabhaskar Prabhakarpandian et al.   JOURNAL OF CONTROLLED RELEASE

Concave microwell array-mediated three-dimensional tumor model for screening anticancer drug-loaded nanoparticles

(2015) AhRan Kang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Erratum: CORRIGENDUM: The Evidence of Glioblastoma Heterogeneity

(2015) Akio Soeda et al.   Scientific Reports

Engineering Cell-Compatible Paper Chips for Cell Culturing, Drug Screening, and Mass Spectrometric Sensing

(2015) Qiushui Chen et al.   Advanced Healthcare Materials

Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System

(2015) Gulden Camci-Unal et al.   Advanced Healthcare Materials

Nanostructures Control the Hepatocellular Responses to a Cytotoxic Agent “Cisplatin”

(2015) Shimaa A. Abdellatef et al.   Biomed Research International

Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline

(2015) Megan C. Cox et al.   ACS Biomaterials-Science & Engineering

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline

(2015) Megan C. Cox et al.   ACS Biomaterials Science & Engineering

Neurite Outgrowth on Electrospun Nanofibers with Uniaxial Alignment: The Effects of Fiber Density, Surface Coating, and Supporting Substrate

(2014) Jingwei Xie et al.   ACS Nano

Lessons from patient-derived xenografts for better in vitro modeling of human cancer

(2014) Stephen Yiu Chuen Choi et al.   ADVANCED DRUG DELIVERY REVIEWS

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics

(2014) Xian Xu et al.   BIOMATERIALS

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Topographical extracellular matrix cues on anticancer drug-induced cytotoxicity in stem cells

(2014) Jangho Kim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Dual-Phase, Surface Tension-Based Fabrication Method for Generation of Tumor Millibeads

(2014) Shantanu Pradhan et al.   LANGMUIR

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Pragmatic issues in biomarker evaluation for targeted therapies in cancer

(2014) Armand de Gramont et al.   Nature Reviews Clinical Oncology

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Three-dimensional printing of Hela cells for cervical tumor modelin vitro

(2014) Yu Zhao et al.   Biofabrication

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Hypoxia-inducible hydrogels

(2014) Kyung Min Park et al.   Nature Communications

Emerging Understanding of Multiscale Tumor Heterogeneity

(2014) Michael J. Gerdes et al.   Frontiers in Oncology

Microfluidics-assisted in vitro drug screening and carrier production

(2013) Jonathan H. Tsui et al.   ADVANCED DRUG DELIVERY REVIEWS

Miniaturized pre-clinical cancer models as research and diagnostic tools

(2013) Maria Håkanson et al.   ADVANCED DRUG DELIVERY REVIEWS

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

(2013) Jennifer N. Beck et al.   BIOMATERIALS

3D printing of biomimetic microstructures for cancer cell migration

(2013) Tina Qing Huang et al.   BIOMEDICAL MICRODEVICES

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel three-dimensional stromal-based model forin vitrochemotherapy sensitivity testing of leukemia cells

(2013) Omar S. Aljitawi et al.   LEUKEMIA & LYMPHOMA

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®

(2013) Andrew S. Mikhail et al.   PLoS One

Application of Concave Microwells to Pancreatic Tumor Spheroids Enabling Anticancer Drug Evaluation in a Clinically Relevant Drug Resistance Model

(2013) Sang-Eun Yeon et al.   PLoS One

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

An integrated in vitro model of perfused tumor and cardiac tissue

(2013) Monica Moya et al.   Stem Cell Research & Therapy

Nanotopography-guided tissue engineering and regenerative medicine

(2012) Hong Nam Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness

(2012) Pranav Soman et al.   BIOMATERIALS

Induced Pluripotent Stem Cells: Past, Present, and Future

(2012) Shinya Yamanaka   Cell Stem Cell

Matrix nanotopography as a regulator of cell function

(2012) Deok-Ho Kim et al.   JOURNAL OF CELL BIOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles-mediated drug delivery approaches for cancer targeting: a review

(2012) Shaheen Sultana et al.   JOURNAL OF DRUG TARGETING

RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis

(2012) Jonathan W. Song et al.   LAB ON A CHIP

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competitive cell interactions in cancer: a cellular tug of war

(2012) Laura Wagstaff et al.   TRENDS IN CELL BIOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning

(2011) Lara Milane et al.   Cancer Cell International

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer

(2011) J. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of anticancer drugs: A review

(2011) Susanne Nussbaumer et al.   TALANTA

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

(2010) Deok-Ho Kim et al.   ADVANCED MATERIALS

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles

(2010) Tae-Hee Kim et al.   BIOMATERIALS

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Biological applications of microfluidic gradient devices

(2010) Sudong Kim et al.   Integrative Biology

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

(2010) Heike Hardelauf et al.   LAB ON A CHIP

Three-dimensional tissue culture based on magnetic cell levitation

(2010) Glauco R. Souza et al.   Nature Nanotechnology

Oxygen-Controlled Three-Dimensional Cultures to Analyze Tumor Angiogenesis

(2010) Scott S. Verbridge et al.   TISSUE ENGINEERING PART A

Microengineered Platforms for Cell Mechanobiology

(2009) Deok-Ho Kim et al.   Annual Review of Biomedical Engineering

Organ printing: Tissue spheroids as building blocks

(2009) Vladimir Mironov et al.   BIOMATERIALS

A physiologically realistic in vitro model of microvascular networks

(2009) Jenna M. Rosano et al.   BIOMEDICAL MICRODEVICES

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

(2009) B. D. Robinson et al.   CLINICAL CANCER RESEARCH

Advancing science and technology via 3D culture on basement membrane matrix

(2009) G. Benton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Simultaneous generation of chemical concentration and mechanical shear stress gradients using microfluidic osmotic flow comparable to interstitial flow

(2009) Joong Yull Park et al.   LAB ON A CHIP

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Paper-supported 3D cell culture for tissue-based bioassays

(2009) R. Derda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor- 1

(2008) J. Ahamed et al.   BLOOD

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging

(2008) Vernella Vickerman et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

(2008) E. A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA