Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment

(2016) Ryan P. Vetreno et al.   ADDICTION BIOLOGY

Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration

(2016) María Antón et al.   ADDICTION BIOLOGY

Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model

(2016) Ana Rubio-Araiz et al.   ADDICTION BIOLOGY

Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol-Drinking Behavior in Alcohol-Dependent Mice

(2016) M. Bajo et al.   ALCOHOL AND ALCOHOLISM

Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence

(2016) Jorge Montesinos et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-1 receptor signaling in the basolateral amygdala modulates binge-like ethanol consumption in male C57BL/6J mice

(2016) S. Alex Marshall et al.   BRAIN BEHAVIOR AND IMMUNITY

Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure

(2016) Anny Gano et al.   BRAIN RESEARCH

Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy

(2016) Jonathan Henry W Jacobsen et al.   CURRENT OPINION IN PHARMACOLOGY

Chronic Intracerebroventricular Infusion of Monocyte Chemoattractant Protein-1 Leads to a Persistent Increase in Sweetened Ethanol Consumption During Operant Self-Administration But Does Not Influence Sucrose Consumption in Long-Evans Rats

(2015) John P. Valenta et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus

(2015) Mary-Louise Risher et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

An Integrative Model of the Maturation of Cognitive Control

(2015) Beatriz Luna et al.   Annual Review of Neuroscience

TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment

(2015) Jorge Montesinos et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury

(2015) Ying Li et al.   NEUROBIOLOGY OF DISEASE

Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB

(2015) Silvia Alfonso-Loeches et al.   NEUROCHEMICAL RESEARCH

Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2

(2015) María Pascual et al.   NEUROPHARMACOLOGY

Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines

(2015) Yuri A. Blednov et al.   NEUROPHARMACOLOGY

Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption

(2015) Dana Most et al.   NEUROPSYCHOPHARMACOLOGY

CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

(2015) Harry L June et al.   NEUROPSYCHOPHARMACOLOGY

Adolescent Intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat

(2015) W. Liu et al.   NEUROSCIENCE

Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?

(2015) Linda Patia Spear   PHYSIOLOGY & BEHAVIOR

Mechanisms of neuroimmune gene induction in alcoholism

(2015) Fulton T. Crews et al.   PSYCHOPHARMACOLOGY

Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning

(2015) Ryan P. Vetreno et al.   Frontiers in Neuroscience

Intoxication- and Withdrawal-Dependent Expression of Central and Peripheral Cytokines Following Initial Ethanol Exposure

(2014) Tamara L. Doremus-Fitzwater et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

(2014) Yu Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Persistent Loss of Hippocampal Neurogenesis and Increased Cell Death following Adolescent, but Not Adult, Chronic Ethanol Exposure

(2014) Margaret A. Broadwater et al.   DEVELOPMENTAL NEUROSCIENCE

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(2014) Melinda Magna et al.   MOLECULAR MEDICINE

Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

(2014) Elissa J. Donzis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Adolescent Alcohol Exposure Reduces Behavioral Flexibility, Promotes Disinhibition and Increases Resistance to Extinction of Ethanol Self-Administration in Adulthood

(2014) Justin T Gass et al.   NEUROPSYCHOPHARMACOLOGY

Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling

(2014) Jian Y. Zou et al.   PLoS One

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems

(2014) Alice Guyon   Frontiers in Cellular Neuroscience

TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

(2014) A Pla et al.   Cell Death & Disease

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

(2013) Richard L. Bell et al.   ADDICTION BIOLOGY

Neuroimmune Activation and Myelin Changes in Adolescent Rats Exposed to High-Dose Alcohol and Associated Cognitive Dysfunction: A Review with Reference to Human Adolescent Drinking

(2013) María Pascual et al.   ALCOHOL AND ALCOHOLISM

The Cytokine mRNA Increase Induced by Withdrawal from Chronic Ethanol in the Sterile Environment of Brain is Mediated by CRF and HMGB1 Release

(2013) Buddy A. Whitman et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning

(2013) Adriana del Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroimmune signaling: a key component of alcohol abuse

(2013) Jody Mayfield et al.   CURRENT OPINION IN NEUROBIOLOGY

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

(2013) Dora Lippai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells

(2013) Sara Fernandez-Lizarbe et al.   JOURNAL OF NEUROCHEMISTRY

LPS or ethanol triggers clathrin- and rafts/caveolae-dependent endocytosis of TLR4 in cortical astrocytes

(2013) Maya Pascual-Lucas et al.   JOURNAL OF NEUROCHEMISTRY

RAGE and TLRs: Relatives, friends or neighbours?

(2013) Zaridatul Aini Ibrahim et al.   MOLECULAR IMMUNOLOGY

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

(2013) Ming Lu et al.   NEUROBIOLOGY OF AGING

Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking

(2013) Ryan P. Vetreno et al.   NEUROBIOLOGY OF DISEASE

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

(2013) Antoine Lampron et al.   NEURON

Motor stereotypies and cognitive perseveration in non-human primates exposed to early gestational irradiation

(2013) L.D. Selemon et al.   NEUROSCIENCE

Phylogeny of Toll-Like Receptor Signaling: Adapting the Innate Response

(2013) Jeffrey M. Roach et al.   PLoS One

Gender differences in alcohol-induced neurotoxicity and brain damage

(2013) Silvia Alfonso-Loeches et al.   TOXICOLOGY

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

(2012) Sophie Leclercq et al.   BRAIN BEHAVIOR AND IMMUNITY

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(2012) Eugenio Mora et al.   CELL CYCLE

Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse

(2012) Silvia Alfonso-Loeches et al.   GLIA

Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome

(2012) Fabio Martinon   IMMUNITY

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

(2012) Sophie Leow-Dyke et al.   Journal of Neuroinflammation

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression

(2012) Jennifer G. Bray et al.   NEUROPHARMACOLOGY

Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex

(2012) R.P. Vetreno et al.   NEUROSCIENCE

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

(2011) Yuri A. Blednov et al.   ADDICTION BIOLOGY

Up-Regulation of MicroRNAs in Brain of Human Alcoholics

(2011) Joanne M. Lewohl et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking

(2011) Serena Stopponi et al.   BIOLOGICAL PSYCHIATRY

Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment

(2011) Yue Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Minocycline reduces ethanol drinking

(2011) R.G. Agrawal et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage

(2011) María Pascual et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

(2011) Y.A. Blednov et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice

(2011) Yue Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of TLR4 in ethanol effects on innate and adaptive immune responses in peritoneal macrophages

(2011) María Pascual et al.   IMMUNOLOGY AND CELL BIOLOGY

Binge alcohol drinking is associated with GABAA  2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence

(2010) Consuelo Guerri et al.   ALCOHOL

Induction of Innate Immune Gene Expression Cascades in Brain Slice Cultures by Ethanol: Key Role of NF-κB and Proinflammatory Cytokines

(2010) Jian Zou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Expression and regulation of toll-like receptors in cerebral endothelial cells

(2010) Péter Nagyőszi et al.   NEUROCHEMISTRY INTERNATIONAL

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol

(2009) S. Fernandez-Lizarbe et al.   JOURNAL OF IMMUNOLOGY

Neuro-inflammation induced in the hippocampus of ‘binge drinking’ rats may be mediated by elevated extracellular glutamate content

(2009) Roberta J. Ward et al.   JOURNAL OF NEUROCHEMISTRY

microRNAs in CNS Disorders

(2009) Jannet Kocerha et al.   NEUROMOLECULAR MEDICINE

Immune Proteins in Brain Development and Synaptic Plasticity

(2009) Lisa M. Boulanger   NEURON

Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide

(2008) J. P. Konsman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ethanol mimics ligand-mediated activation and endocytosis of IL-1RITLR4 receptors vialipid raftscaveolae in astroglial cells

(2008) Ana M. Blanco et al.   JOURNAL OF NEUROCHEMISTRY

Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

(2008) Liya Qin et al.   Journal of Neuroinflammation

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY