Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model

Alcohol Alters the Activation of ERK1/2, a Functional Regulator of Binge Alcohol Drinking in Adult C57BL/6J Mice

(2015) Abigail E. Agoglia et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Roundabout 4 Regulates Blood–Tumor Barrier Permeability Through the Modulation of ZO-1, Occludin, and Claudin-5 Expression

(2015) Heng Cai et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2

(2015) María Pascual et al.   NEUROPHARMACOLOGY

Erythropoietin protects against hemorrhagic blood–brain barrier disruption through the effects of aquaporin-4

(2014) Heling Chu et al.   LABORATORY INVESTIGATION

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

Protective Effect of Shikonin in Experimental Ischemic Stroke: Attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 Expression, Up-Regulated Claudin-5 Expression, Ameliorated BBB Permeability

(2013) Lina Wang et al.   NEUROCHEMICAL RESEARCH

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

A study on the effect of JNK inhibitor, SP600125, on the disruption of blood–brain barrier induced by methamphetamine

(2012) Andres Urrutia et al.   NEUROBIOLOGY OF DISEASE

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

(2011) Yuri A. Blednov et al.   ADDICTION BIOLOGY

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

(2011) Y.A. Blednov et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1

(2011) M. Maroso et al.   JOURNAL OF INTERNAL MEDICINE

Mild Stretch-Induced Injury Increases Susceptibility to Interleukin-1β-Induced Release of Matrix Metalloproteinase-9 from Astrocytes

(2011) Hantamalala Ralay Ranaivo et al.   JOURNAL OF NEUROTRAUMA

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hemoglobin-Induced Oxidative Stress Contributes to Matrix Metalloproteinase Activation and Blood–Brain Barrier Dysfunction in vivo

(2010) Masataka Katsu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

(2010) Rong Jin et al.   NEUROBIOLOGY OF DISEASE

Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1β levels and leakage of the blood-brain barrier

(2009) Weiming Tian et al.   MATRIX BIOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Ethanol mimics ligand-mediated activation and endocytosis of IL-1RITLR4 receptors vialipid raftscaveolae in astroglial cells

(2008) Ana M. Blanco et al.   JOURNAL OF NEUROCHEMISTRY

Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines

(2008) Britta Engelhardt   JOURNAL OF THE NEUROLOGICAL SCIENCES

MMP-9–Positive Neutrophil Infiltration Is Associated to Blood–Brain Barrier Breakdown and Basal Lamina Type IV Collagen Degradation During Hemorrhagic Transformation After Human Ischemic Stroke

(2008) Anna Rosell et al.   STROKE

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY

Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages

(2007) Sara Fernandez-Lizarbe et al.   MOLECULAR IMMUNOLOGY