Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

Medications development to treat alcohol dependence: a vision for the next decade

(2012) Raye Z. Litten et al.   ADDICTION BIOLOGY

The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats

(2012) Rui-Ting Wen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

(2012) Liya Qin et al.   Journal of Neuroinflammation

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

(2011) Yuri A. Blednov et al.   ADDICTION BIOLOGY

Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of innate immune genes in brain create the neurobiology of addiction

(2011) F.T. Crews et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of phosphodiesterase-4 decreases ethanol intake in mice

(2011) Wei Hu et al.   PSYCHOPHARMACOLOGY

A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease

(2010) Aaron P. Kithcart et al.   FASEB JOURNAL

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

(2010) Y. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease

(2009) P Rolan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues

(2009) Markus Heilig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses

(2008) Paul Rolan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens

(2008) William C. Griffin et al.   PSYCHOPHARMACOLOGY